Gamma-Glutamyl Transpeptidases: Structure and Function
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Basel
Springer
2013
|
| Series: | SpringerBriefs in Biochemistry and Molecular Biology
|
| Online Access: | FAN01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Physical Description: | 1 Online-Ressource |
| ISBN: | 9783034806824 |
| DOI: | 10.1007/978-3-0348-0682-4 |
Staff View
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Record in the Search Index
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| adam_text | GAMMA-GLUTAMYL TRANSPEPTIDASES
/ CASTELLANO, IMMACOLATA
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1 INTRODUCTION
2 OCCURRENCE, GENES AND GENE EXPRESSION
3 STRUCTURE AND FUNCTION OF Γ-GTS
4 AUTOPROCESSING AND REACTION MECHANISM OF Γ-GTS
5 Γ-GT IN BIOCLINICAL
6 Γ-GTS: BIOTECHNOLOGICAL AND BIOMEDICAL APPLICATIONS
7 CONCLUSIONS
REFERENCES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
GAMMA-GLUTAMYL TRANSPEPTIDASES
/ CASTELLANO, IMMACOLATA
: 2013
ABSTRACT / INHALTSTEXT
GAMMA-GLUTAMYL TRANSPEPTIDASES (Γ-GTS) ARE MEMBERS OF THE N-TERMINAL
NUCLEOPHILE HYDROLASE SUPERFAMILY, ENZYMES THAT CLEAVE THE Γ-GLUTAMYL
AMIDE BOND OF GLUTATHIONE TO LIBERATE CYSTEINYLGLYCINE. THE RELEASED
Γ-GLUTAMYL GROUP CAN BE TRANSFERRED TO WATER (HYDROLYSIS) OR TO AMINO
ACIDS OR SHORT PEPTIDES (TRANSPEPTIDATION). Γ-GT PLAYS A KEY ROLE IN
THE GAMMA GLUTAMYL CYCLE BY REGULATING THE CELLULAR LEVELS OF THE
ANTIOXIDANT GLUTATHIONE, HENCE IT IS A CRITICAL ENZYME IN MAINTAINING
CELLULAR REDOX HOMEOSTASIS.Γ-GT IS UPREGULATED DURING INFLAMMATION AND
IN SEVERAL HUMAN TUMORS, AND IT IS INVOLVED IN MANY PHYSIOLOGICAL
DISORDERS RELATED TO OXIDATIVE STRESS, SUCH AS PARKINSON’S DISEASE AND
DIABETES. FURTHERMORE, THIS ENZYME IS USED AS A MARKER OF LIVER DISEASE
AND CANCER. THIS BOOK COVERSCURRENT KNOWLEDGE ABOUT THE
STRUCTURE-FUNCTION RELATIONSHIP OF Γ-GTS ANDGIVES INFORMATION
ABOUTAPPLICATIONS OF Γ-GTS IN DIFFERENT FIELDS RANGING FROM CLINICAL
BIOCHEMISTRY TO BIOTECHNOLOGY AND BIOMEDICINE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.6 |
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| discipline | Biologie |
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| spelling | Castellano, Immacolata Verfasser aut Gamma-Glutamyl Transpeptidases Structure and Function Immacolata Castellano ; Antonello Merlino Basel Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier SpringerBriefs in Biochemistry and Molecular Biology Merlino, Antonello Verfasser aut Erscheint auch als Druckausgabe 978-3-0348-0681-7 https://doi.org/10.1007/978-3-0348-0682-4 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026175876&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026175876&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Castellano, Immacolata Merlino, Antonello Gamma-Glutamyl Transpeptidases Structure and Function |
| title | Gamma-Glutamyl Transpeptidases Structure and Function |
| title_auth | Gamma-Glutamyl Transpeptidases Structure and Function |
| title_exact_search | Gamma-Glutamyl Transpeptidases Structure and Function |
| title_full | Gamma-Glutamyl Transpeptidases Structure and Function Immacolata Castellano ; Antonello Merlino |
| title_fullStr | Gamma-Glutamyl Transpeptidases Structure and Function Immacolata Castellano ; Antonello Merlino |
| title_full_unstemmed | Gamma-Glutamyl Transpeptidases Structure and Function Immacolata Castellano ; Antonello Merlino |
| title_short | Gamma-Glutamyl Transpeptidases |
| title_sort | gamma glutamyl transpeptidases structure and function |
| title_sub | Structure and Function |
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