Graves’ Disease: Pathogenesis and Treatment
From the perspective of the investigator, Graves' disease is a fascinating disorder with unique features and opportunities for study. The discovery in 1956 that Graves' disease was caused by a humoral factor, later shown to be an antibody to the TSH receptor, was a triumph for modern inves...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
2000
|
| Schriftenreihe: | Endocrine Updates
6 |
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | From the perspective of the investigator, Graves' disease is a fascinating disorder with unique features and opportunities for study. The discovery in 1956 that Graves' disease was caused by a humoral factor, later shown to be an antibody to the TSH receptor, was a triumph for modern investigative medicine. Rapid progress is now being made in (i) understanding the molecular interaction between autoantibodies and the TSH receptor, (ii) identifying the genes that contribute to the predisposition to disease, (iii) developing an animal model of Graves' disease, and (iv) identifying the long-sought orbital antigen in ophthalmopathy. From the clinical standpoint, although Graves' disease is eminently treatable, there is no definitive cure. None of the therapeutic options are ideal. It is hoped that rapid progress in understanding the pathogenesis of the disease will lead to the ultimate goal of some form of immunotherapy that will make antithyroid drugs, radioiodine and thyroidectomy obsolete. The chapters in Graves' Disease: Pathogenesis and Treatment represent the viewpoints of many prominent clinicians and investigators working in the field. The editors are grateful for their contributions which cover an unusually comprehensive compendium of subjects relating to the disease |
| Beschreibung: | 1 Online-Ressource (XIII, 307 p) |
| ISBN: | 9781461544074 |
| DOI: | 10.1007/978-1-4615-4407-4 |
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| 520 | |a From the perspective of the investigator, Graves' disease is a fascinating disorder with unique features and opportunities for study. The discovery in 1956 that Graves' disease was caused by a humoral factor, later shown to be an antibody to the TSH receptor, was a triumph for modern investigative medicine. Rapid progress is now being made in (i) understanding the molecular interaction between autoantibodies and the TSH receptor, (ii) identifying the genes that contribute to the predisposition to disease, (iii) developing an animal model of Graves' disease, and (iv) identifying the long-sought orbital antigen in ophthalmopathy. From the clinical standpoint, although Graves' disease is eminently treatable, there is no definitive cure. None of the therapeutic options are ideal. It is hoped that rapid progress in understanding the pathogenesis of the disease will lead to the ultimate goal of some form of immunotherapy that will make antithyroid drugs, radioiodine and thyroidectomy obsolete. The chapters in Graves' Disease: Pathogenesis and Treatment represent the viewpoints of many prominent clinicians and investigators working in the field. The editors are grateful for their contributions which cover an unusually comprehensive compendium of subjects relating to the disease | ||
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| discipline | Medizin |
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| spelling | Graves’ Disease Pathogenesis and Treatment edited by Basil Rapoport, Sandra M. McLachlan Boston, MA Springer US 2000 1 Online-Ressource (XIII, 307 p) txt rdacontent c rdamedia cr rdacarrier Endocrine Updates 6 From the perspective of the investigator, Graves' disease is a fascinating disorder with unique features and opportunities for study. The discovery in 1956 that Graves' disease was caused by a humoral factor, later shown to be an antibody to the TSH receptor, was a triumph for modern investigative medicine. Rapid progress is now being made in (i) understanding the molecular interaction between autoantibodies and the TSH receptor, (ii) identifying the genes that contribute to the predisposition to disease, (iii) developing an animal model of Graves' disease, and (iv) identifying the long-sought orbital antigen in ophthalmopathy. From the clinical standpoint, although Graves' disease is eminently treatable, there is no definitive cure. None of the therapeutic options are ideal. It is hoped that rapid progress in understanding the pathogenesis of the disease will lead to the ultimate goal of some form of immunotherapy that will make antithyroid drugs, radioiodine and thyroidectomy obsolete. The chapters in Graves' Disease: Pathogenesis and Treatment represent the viewpoints of many prominent clinicians and investigators working in the field. The editors are grateful for their contributions which cover an unusually comprehensive compendium of subjects relating to the disease Diabetes Immunology Ophthalmology Basedow-Krankheit (DE-588)4144092-4 gnd rswk-swf Basedow-Krankheit (DE-588)4144092-4 s 1\p DE-604 Rapoport, Basil edt McLachlan, Sandra M. edt Erscheint auch als Druck-Ausgabe 9780792377900 Erscheint auch als Druck-Ausgabe 9781461369837 Erscheint auch als Druck-Ausgabe 9781461544081 https://doi.org/10.1007/978-1-4615-4407-4 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Graves’ Disease Pathogenesis and Treatment Diabetes Immunology Ophthalmology Basedow-Krankheit (DE-588)4144092-4 gnd |
| subject_GND | (DE-588)4144092-4 |
| title | Graves’ Disease Pathogenesis and Treatment |
| title_auth | Graves’ Disease Pathogenesis and Treatment |
| title_exact_search | Graves’ Disease Pathogenesis and Treatment |
| title_full | Graves’ Disease Pathogenesis and Treatment edited by Basil Rapoport, Sandra M. McLachlan |
| title_fullStr | Graves’ Disease Pathogenesis and Treatment edited by Basil Rapoport, Sandra M. McLachlan |
| title_full_unstemmed | Graves’ Disease Pathogenesis and Treatment edited by Basil Rapoport, Sandra M. McLachlan |
| title_short | Graves’ Disease |
| title_sort | graves disease pathogenesis and treatment |
| title_sub | Pathogenesis and Treatment |
| topic | Diabetes Immunology Ophthalmology Basedow-Krankheit (DE-588)4144092-4 gnd |
| topic_facet | Diabetes Immunology Ophthalmology Basedow-Krankheit |
| url | https://doi.org/10.1007/978-1-4615-4407-4 |
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