Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology: Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000
More then 20 years have passed now since the first recombinant protein producing microorganisms have been developed. In the meanwhile, numerous proteins have been produced in bacteria, yeasts and filamentous fungi, as weIl as higher eukaryotic cells, and even entire plants and animals. Many recombin...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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Dordrecht
Springer Netherlands
2001
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| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | More then 20 years have passed now since the first recombinant protein producing microorganisms have been developed. In the meanwhile, numerous proteins have been produced in bacteria, yeasts and filamentous fungi, as weIl as higher eukaryotic cells, and even entire plants and animals. Many recombinant proteins are on the market today, and some of them reached substantial market volumes. On the first sight one would expect the technology - including the physiology of the host strains - to be optimised in detail after a 20 year's period of development. However, several constraints have limited the incentive for optimisation, especially in the pharmaceutical industry like the urge to proceed quickly or the requirement to define the production parameters for registration early in the development phase. The additional expenses for registration of a new production strain often prohibits a change to an optimised strain. A continuous optimisation of the entire production process is not feasible for the same reasons |
| Beschreibung: | 1 Online-Ressource (X, 400 p) |
| ISBN: | 9789401597494 |
| DOI: | 10.1007/978-94-015-9749-4 |
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| 520 | |a More then 20 years have passed now since the first recombinant protein producing microorganisms have been developed. In the meanwhile, numerous proteins have been produced in bacteria, yeasts and filamentous fungi, as weIl as higher eukaryotic cells, and even entire plants and animals. Many recombinant proteins are on the market today, and some of them reached substantial market volumes. On the first sight one would expect the technology - including the physiology of the host strains - to be optimised in detail after a 20 year's period of development. However, several constraints have limited the incentive for optimisation, especially in the pharmaceutical industry like the urge to proceed quickly or the requirement to define the production parameters for registration early in the development phase. The additional expenses for registration of a new production strain often prohibits a change to an optimised strain. A continuous optimisation of the entire production process is not feasible for the same reasons | ||
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| spelling | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 edited by O.-W. Merten, D. Mattanovich, C. Lang, G. Larsson, P. Neubauer, D. Porro, P. Postma, J. Teixeira de Mattos, J. A. Cole Selected Articles from the Meeting of the EFB Section on Microbial Physiology, Semmering/A, 5-8 October 2000 Dordrecht Springer Netherlands 2001 1 Online-Ressource (X, 400 p) txt rdacontent c rdamedia cr rdacarrier More then 20 years have passed now since the first recombinant protein producing microorganisms have been developed. In the meanwhile, numerous proteins have been produced in bacteria, yeasts and filamentous fungi, as weIl as higher eukaryotic cells, and even entire plants and animals. Many recombinant proteins are on the market today, and some of them reached substantial market volumes. On the first sight one would expect the technology - including the physiology of the host strains - to be optimised in detail after a 20 year's period of development. However, several constraints have limited the incentive for optimisation, especially in the pharmaceutical industry like the urge to proceed quickly or the requirement to define the production parameters for registration early in the development phase. The additional expenses for registration of a new production strain often prohibits a change to an optimised strain. A continuous optimisation of the entire production process is not feasible for the same reasons Protein Science Biochemistry, general Microbiology Animal Anatomy / Morphology / Histology Animal Biochemistry Biochemical Engineering Biochemistry Morphology (Animals) Biochemical engineering Rekombinantes Protein (DE-588)4277353-2 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2000 Semmering gnd-content Rekombinantes Protein (DE-588)4277353-2 s DE-604 Merten, O.-W. edt Mattanovich, D. edt Lang, C. edt Larsson, G. edt Erscheint auch als Druck-Ausgabe 9789048157563 Erscheint auch als Druck-Ausgabe 9780792371373 Erscheint auch als Druck-Ausgabe 9789401597500 https://doi.org/10.1007/978-94-015-9749-4 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 Protein Science Biochemistry, general Microbiology Animal Anatomy / Morphology / Histology Animal Biochemistry Biochemical Engineering Biochemistry Morphology (Animals) Biochemical engineering Rekombinantes Protein (DE-588)4277353-2 gnd |
| subject_GND | (DE-588)4277353-2 (DE-588)1071861417 |
| title | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 |
| title_alt | Selected Articles from the Meeting of the EFB Section on Microbial Physiology, Semmering/A, 5-8 October 2000 |
| title_auth | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 |
| title_exact_search | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 |
| title_full | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 edited by O.-W. Merten, D. Mattanovich, C. Lang, G. Larsson, P. Neubauer, D. Porro, P. Postma, J. Teixeira de Mattos, J. A. Cole |
| title_fullStr | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 edited by O.-W. Merten, D. Mattanovich, C. Lang, G. Larsson, P. Neubauer, D. Porro, P. Postma, J. Teixeira de Mattos, J. A. Cole |
| title_full_unstemmed | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 edited by O.-W. Merten, D. Mattanovich, C. Lang, G. Larsson, P. Neubauer, D. Porro, P. Postma, J. Teixeira de Mattos, J. A. Cole |
| title_short | Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology |
| title_sort | recombinant protein production with prokaryotic and eukaryotic cells a comparative view on host physiology selected articles from the meeting of the efb section on microbial physiology semmering austria 5th 8th october 2000 |
| title_sub | Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 |
| topic | Protein Science Biochemistry, general Microbiology Animal Anatomy / Morphology / Histology Animal Biochemistry Biochemical Engineering Biochemistry Morphology (Animals) Biochemical engineering Rekombinantes Protein (DE-588)4277353-2 gnd |
| topic_facet | Protein Science Biochemistry, general Microbiology Animal Anatomy / Morphology / Histology Animal Biochemistry Biochemical Engineering Biochemistry Morphology (Animals) Biochemical engineering Rekombinantes Protein Konferenzschrift 2000 Semmering |
| url | https://doi.org/10.1007/978-94-015-9749-4 |
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