Developing guided and unbiased drug screening approaches for Toxoplasma gondii:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Freiburg im Breisgau
2020
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Enthält 2 Sonderabdrucke |
| Beschreibung: | X, 98 Seiten, 24 verschieden gezählte Seiten Illustrationen, Diagramme 30 cm |
Internformat
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| 245 | 1 | 0 | |a Developing guided and unbiased drug screening approaches for Toxoplasma gondii |c vorgelegt von Benedikt Moritz Markus |
| 264 | 1 | |a Freiburg im Breisgau |c 2020 | |
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Datensatz im Suchindex
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| adam_txt |
TABLE
OF
CONTENTS
ACKNOWLEDGEMENTS
.
I
ABSTRACT
.
ILL
TABLE
OF
CONTENTS
.
V
LIST
OF
FIGURES
AND
TABLES
.
VII
LIST
OF
ABBREVIATIONS
.
VIII
1
INTRODUCTION
.
1
1.1
TOXOPLASMOSIS
AND
ITS
AETIOLOGICAL
AGENT
.
1
1.1.1
FROM
DISCOVERY
TO
RECOGNITION
AS
A
UBIQUITOUS
PARASITE
.
1
1.1.2
TOXOPLASMAS
LIFE
CYCLE
.
2
1.1.3
HUMAN
TOXOPLASMOSIS
.
4
1.1.4
TOXOPLASMA
*
A
CELL-BIOLOGICAL
MODEL
FOR
THE
APICOMPLEXAN
PHYLUM
.6
1.2
APPROACHES
TO
DRUG
TARGET
IDENTIFICATION
IN
TOXOPLASMA
.
9
1.2.1
THE
IMPORTANCE
OF
TARGET
IDENTIFICATION
.9
1.2.2
EMERGING
FUNCTIONAL
GENOMICS
TOOLS
FOR
CHEMICAL-GENETIC
SCREENS
IN
TOXOPLASMA
.
10
1.3
APICOMPLEXAN
CDPKS
AS
TARGETS
FOR
THERAPEUTIC
INTERVENTION
.
12
1.3.1
CDPKS
MEDIATE
ESSENTIAL
LIFE-CYCLE
TRANSITIONS
IN
APICOMPLEXAN
PARASITES
.
12
1.3.2
CDPKS
REPRESENT
ATTRACTIVE
DRUG
TARGETS
.
14
1.3.3
CDPKS
ARE
REGULATED
BY
A
C-TERMINAL
CALMODULIN-LIKE
DOMAIN
.
15
1.3.4
THE
ANTIBODY
1B7
IS
A
POTENT
INHIBITOR
OF
TOXOPLASMA
CDPK1
AND
RELATED
KINASES
.
17
2
AIMS
.19
3
RESULTS
.
21
3.1
AN
INTEGRATED
SCREENING
PLATFORM
FOR
ALLOSTERIC
INHIBITORS
OF
THE
ESSENTIAL
PROTEIN
KINASE
CDPK1
.
21
3.2
DEVELOPING
FUNCTIONAL
GENOMICS
TOOLS
FOR
THE
UNBIASED
IDENTIFICATION
OF
DRUG
TARGETS
.
33
3.3
MAPPING
AND
CHARACTERIZING
THE
TRANSCRIPTION-INITIATION
LANDSCAPE
IN
TACHYZOITES
AND
BRADYZOITES
.
49
4
DISCUSSION
.
65
4.1
AN
INTEGRATED
SCREENING
PLATFORM
FOR
ALLOSTERIC
INHIBITORS
OF
THE
ESSENTIAL
PROTEIN
KINASE
CDPK1
.
65
4.2
DEVELOPING
FUNCTIONAL
GENOMICS
TOOLS
FOR
THE
UNBIASED
IDENTIFICATION
OF
DRUG
TARGETS
.
67
4.3
MAPPING
AND
CHARACTERIZING
THE
TRANSCRIPTION-INITIATION
LANDSCAPE
IN
TACHYZOITES
AND
BRADYZOITES
.
69
5
MATERIALS
AND
METHODS
.
72
V
5.1
AN
INTEGRATED
SCREENING
PLATFORM
FOR
ALLOSTERIC
INHIBITORS
OF
THE
ESSENTIAL
PROTEIN
KINASE
CDPK1
.
72
5.2
DEVELOPING
FUNCTIONAL
GENOMICS
TOOLS
FOR
THE
UNBIASED
IDENTIFICATION
OF
DRUG
TARGETS
.
75
5.3
MAPPING
AND
CHARACTERIZING
THE
TRANSCRIPTION-INITIATION
LANDSCAPE
IN
TACHYZOITES
AND
BRADYZOITES
.
80
6
CO-AUTHORSHIPS
.
86
7
REFERENCES
.
87
8
APPENDIX
(RELEVANT
FIRST-AUTHOR
PUBLICATIONS)
.
98
8.1
APPENDIX
1:
ALLOSTERIC
ACTIVATION
OF
APICOMPLEXAN
CALCIUM-DEPENDENT
PROTEIN
KINASES
.
98
8.2
APPENDIX
2:
OPTIMIZING
SYSTEMS
FOR
CAS9
EXPRESSION
IN
TOXOPLASMA
GONDII
.
98
VI |
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| author | Markus, Benedikt Moritz |
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| author_facet | Markus, Benedikt Moritz |
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| bvnumber | BV046887913 |
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| discipline_str_mv | Biologie Medizin |
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| language | English |
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| spelling | Markus, Benedikt Moritz Verfasser (DE-588)1213837316 aut Developing guided and unbiased drug screening approaches for Toxoplasma gondii vorgelegt von Benedikt Moritz Markus Freiburg im Breisgau 2020 X, 98 Seiten, 24 verschieden gezählte Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Enthält 2 Sonderabdrucke Dissertation Albert-Ludwigs-Universität Freiburg 2020 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1213554969/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032297800&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Markus, Benedikt Moritz Developing guided and unbiased drug screening approaches for Toxoplasma gondii |
| subject_GND | (DE-588)4113937-9 |
| title | Developing guided and unbiased drug screening approaches for Toxoplasma gondii |
| title_auth | Developing guided and unbiased drug screening approaches for Toxoplasma gondii |
| title_exact_search | Developing guided and unbiased drug screening approaches for Toxoplasma gondii |
| title_exact_search_txtP | Developing guided and unbiased drug screening approaches for Toxoplasma gondii |
| title_full | Developing guided and unbiased drug screening approaches for Toxoplasma gondii vorgelegt von Benedikt Moritz Markus |
| title_fullStr | Developing guided and unbiased drug screening approaches for Toxoplasma gondii vorgelegt von Benedikt Moritz Markus |
| title_full_unstemmed | Developing guided and unbiased drug screening approaches for Toxoplasma gondii vorgelegt von Benedikt Moritz Markus |
| title_short | Developing guided and unbiased drug screening approaches for Toxoplasma gondii |
| title_sort | developing guided and unbiased drug screening approaches for toxoplasma gondii |
| topic_facet | Hochschulschrift |
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| work_keys_str_mv | AT markusbenediktmoritz developingguidedandunbiaseddrugscreeningapproachesfortoxoplasmagondii |
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