Glycoprotein hormone receptor signaling in the endosomal compartment: = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Würzburg
April 2016
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Volltext Inhaltsverzeichnis |
| Beschreibung: | veröffentlicht 2017 |
| Beschreibung: | 134 Seiten Illustrationen, Diagramme 30 cm |
Internformat
MARC
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| 100 | 1 | |a Lyga, Sandra |d 1986- |e Verfasser |0 (DE-588)1149302607 |4 aut | |
| 245 | 1 | 0 | |a Glycoprotein hormone receptor signaling in the endosomal compartment |b = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment |c submitted by Sandra Lyga from Gießen |
| 246 | 1 | 1 | |a Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment |
| 264 | 1 | |a Würzburg |c April 2016 | |
| 300 | |a 134 Seiten |b Illustrationen, Diagramme |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a veröffentlicht 2017 | ||
| 502 | |b Dissertation |c Julius-Maximilians-Universität Würzburg |d 2016 | ||
| 546 | |a Zusammenfassung in deutscher und englischer Sprache | ||
| 650 | 0 | 7 | |a Signaltransduktion |0 (DE-588)4318717-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a G-Protein gekoppelter Rezeptor |0 (DE-588)7723480-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Endosom |0 (DE-588)4570819-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Cyclo-AMP |0 (DE-588)4148493-9 |2 gnd |9 rswk-swf |
| 653 | |a Glycoprotein hormone | ||
| 653 | |a Receptor internalization | ||
| 653 | |a cAMP signaling | ||
| 653 | |a PKA signaling | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a G-Protein gekoppelter Rezeptor |0 (DE-588)7723480-7 |D s |
| 689 | 0 | 1 | |a Cyclo-AMP |0 (DE-588)4148493-9 |D s |
| 689 | 0 | 2 | |a Signaltransduktion |0 (DE-588)4318717-1 |D s |
| 689 | 0 | 3 | |a Endosom |0 (DE-588)4570819-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:20-opus-139994 |a Lyga, Sandra, 1986- |t Glycoprotein hormone receptor signaling in the endosomal compartment |d Würzburg : Universität Würzburg, 2016 |h Online-Ressource |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u http://d-nb.info/1149302453/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 1 | |u https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-139994 |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030273748&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-030273748 | ||
Datensatz im Suchindex
| _version_ | 1804178416593797120 |
|---|---|
| adam_text | TABLE OF CONTENTS
FIGURE IN D
EX..................................................................................................................................
3
ABBREVIATIONS................................................................................................................................5
1.
INTRODUCTION...........................................................................................................................
8
1.1. GPCR SIGNALING AND ITS PHYSIOLOGICAL RELEVANCE
........................................................
8
1.1.1. RECEPTOR DESENSITIZATION AND
INTERNALIZATION....................................................................................9
1.1.2. NEW FUNCTIONAL ROLE OF GPCR INTERNALIZATION
..................................................................................
12
1.2. LH RECEPTOR SIGNALING IN OVARIAN FOLLICLES AND ITS PHYSIOLOGICAL
RELEVANCE
...........
15
1.2.1. LH RECEPTOR
INTERNALIZATION..................................................................................................................
19
1.3. TSH RECEPTOR SIGNALING IN THYROID CELLS AND ITS PHYSIOLOGICAL
RELEVANCE
..............
20
1.3.1. PROTEIN KINASE A SIGNALING IN THYROID
CELLS.......................................................................................23
1.3.2. TSH RECEPTOR
INTERNALIZATION..............................................................................................................
25
1.4. METHODS FOR VISUALIZATION OF CAM P AND PKA DYNAMICS
..........................................
26
1.4.1. PRINCIPLE OF FLUORESCENCE RESONANCE ENERGY TRANSFER
..................................................................
26
1.4.2. BIOSENSORS FOR VISUALIZATION OF CAMP DYNAMICS
...........................................................................
28
1.4.3. BIOSENSORS FOR VISUALIZATION OF PKA DYNAM
ICS...............................................................................30
2. AIM OF THE
STUDY.................................................................................................................32
3. MATERIALS UND M
ETHODS.....................................................................................................33
3.1.
MATERIALS.........................................................................................................................
33
3.1.1. CELL LINES AND MOUSE
STRAINS..............................................................................................................33
3.1.2. PLASMID
VECTORS....................................................................................................................................
33
3.1.3. ENZYM
ES................................................................................................................................................33
3.1.4. ANTIBODIES....................................................
3.1.5. CHEMICALS....................................................
3.1.6. MATERIALS FOR CELL CULTURE............................
3.1.7. KITS AND REAGENTS
.......................................
3.2. METHODS..................................................
3.2.1. GENETIC ENGINEERING
...................................
3.2.2. CELL CULTURE AND TRANSFECTION TECHNIQUES
3.2.3. BIOCHEMICAL TECHNIQUES............................
3.2.4. MOLECULAR BIOLOGY TECHNIQUES
.................
.
3.2.5. L125-HCG U
PTAKE........................................................................................
49
3.2.6. LH
LABELING............................................................................................................................................
50
3.2.7. FRET-BASED MEASUREMENTS OF CAMP LEVELS AND PKA ACTIVITY
.................................................
51
3.2.8. CONFOCAL
MICROSCOPY..........................................................................................................................
54
3.2.9.
STATISTICS...............................................................................................................................
55
KUETZ 8 8 8 8 8 8
4. R
ESULTS...................................................................................................................................
57
4.1. MEASUREMENTS OF LH RECEPTOR SIGNALING IN INTACT OVARIAN FOLLICLES
.........................
57
4.1.1. REAL-TIME MONITORING OF CAMP SIGNALING IN OVARIAN FOLLICLES
.......................................................
57
4.1.2. PERSISTENT CAMP/LH RECEPTOR SIGNALING IN INTACT OVARIAN FOLLICLES
..............................................
62
4.1.3. VISUALIZATION OF LH RECEPTOR INTERNALIZATION IN INTACT OVARIAN
FOLLICLES........................................64
4.1.4. EFFECT OF LH RECEPTOR INTERNALIZATION ON CAMP
SIGNALING.............................................................
67
4.1.5. ANALYSIS OF THE EFFECT OF LH RECEPTOR INTERNALIZATION ON MEIOSIS
RESUMPTION IN INTACT OVARIAN
FOLLICLES
...................................................................................................................................................................
70
4.2. MEASUREMENTS OF TSH RECEPTOR SIGNALING IN PRIMARY THYROID CELLS
........................
72
4.2.1. FRET-BASED MEASUREMENTS OF TSH-INDUCED CAMP SIGNALING IN WHOLE
THYROID CELLS
...........
72
4.2.2. FRET-BASED MEASUREMENTS OF TSH-INDUCED PKA SIGNALING IN WHOLE
THYROID CELLS
.............
74
4.2.3. CHARACTERIZATION OF THE BIPHASIC PKA
ACTIVATION............................................................................
76
4.2.4. ANALYSIS OF THE EFFECT OF TSH RECEPTOR INTERNALIZATION ON G S
SIGNALING IN THYROID CELLS
.........
81
4.2.5. IMPACT OF TSH RECEPTOR INTERNALIZATION ON NUCLEAR PKA SIGNALING
IN PRIMARY THYROID CELLS.. 86
5.
DISCUSSION............................................................................................................................
89
5.1. MEASUREMENTS OF LH RECEPTOR SIGNALING IN INTACT OVARIAN FOLLICLES
.........................
89
5.1.1. PROPAGATION OF CAMP WAVE THROUGH/IN DIFFERENT OVARIAN FOLLICLE
COMPARTMENTS
.....................
89
5.1.2. PERSISTENT CAMP/LH RECEPTOR SIGNALING IN INTACT OVARIAN FOLLICLES
..............................................
90
5.1.3. LH RECEPTOR INTERNALIZATION IS REQUIRED FOR EFFICIENT CAMP
SIGNALING
.........................................
92
5.1.4. LH RECEPTOR INTERNALIZATION CONTRIBUTES TO MEIOSIS RESUMPTION IN
INTACT OVARIAN FOLLICLES .... 94
5.2. MEASUREMENTS OF TSH RECEPTOR SIGNALING IN PRIMARY THYROID CELLS
........................
98
5.2.1. TSH INDUCES MULTIPLE WAVES OF SPATIALLY AND KINETICALLY DISTINCT
PKA SIGNALING
......................
98
5.2.2. BLOCKING TSH RECEPTOR INTERNALIZATION ABOLISHES THE SECOND PHASE
OF PKA SIGNALING IN
THYROID
CELLS.............................................................................................................................................................103
5.2.3. TSH RECEPTOR INTERNALIZATION IS REQUIRED FOR EFFICIENT CREB
PHOSPHORYLATION AND GENE
TRANSCRIPTION IN THYROID
CELLS................................................................................................................................
105
5.3. STRENGTHS, LIMITATIONS AND POSSIBLE IMPROVEMENTS
...............................................
107
5.4.
OUTLOOK..........................................................................................................................
109
6. SUM M
ARY.............................................................................................................................
111
7.
BIBLIOGRAPHY.......................................................................................................................115
8.
APPENDIX.............................................................................................................................
127
8.1. PLASMID
MAPS...............................................................................................................
127
8.2. CURRICULUM
VITAE...........................................................................................................
129
8.3. PUBLICATION LIST AND CONFERENCE
CONTRIBUTIONS.........................................................131
8.4.
AFFIDAVIT..........................................................................................................................
133
8.5.
ACKNOWLEDGMENT.........................................................................................................
134
|
| any_adam_object | 1 |
| author | Lyga, Sandra 1986- |
| author_GND | (DE-588)1149302607 |
| author_facet | Lyga, Sandra 1986- |
| author_role | aut |
| author_sort | Lyga, Sandra 1986- |
| author_variant | s l sl |
| building | Verbundindex |
| bvnumber | BV044879494 |
| collection | ebook |
| ctrlnum | (OCoLC)1104929619 (DE-599)DNB1149302453 |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| id | DE-604.BV044879494 |
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| indexdate | 2024-07-10T08:03:38Z |
| institution | BVB |
| language | English |
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| open_access_boolean | 1 |
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| physical | 134 Seiten Illustrationen, Diagramme 30 cm |
| psigel | ebook |
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| spelling | Lyga, Sandra 1986- Verfasser (DE-588)1149302607 aut Glycoprotein hormone receptor signaling in the endosomal compartment = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment submitted by Sandra Lyga from Gießen Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment Würzburg April 2016 134 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier veröffentlicht 2017 Dissertation Julius-Maximilians-Universität Würzburg 2016 Zusammenfassung in deutscher und englischer Sprache Signaltransduktion (DE-588)4318717-1 gnd rswk-swf G-Protein gekoppelter Rezeptor (DE-588)7723480-7 gnd rswk-swf Endosom (DE-588)4570819-8 gnd rswk-swf Cyclo-AMP (DE-588)4148493-9 gnd rswk-swf Glycoprotein hormone Receptor internalization cAMP signaling PKA signaling (DE-588)4113937-9 Hochschulschrift gnd-content G-Protein gekoppelter Rezeptor (DE-588)7723480-7 s Cyclo-AMP (DE-588)4148493-9 s Signaltransduktion (DE-588)4318717-1 s Endosom (DE-588)4570819-8 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-139994 Lyga, Sandra, 1986- Glycoprotein hormone receptor signaling in the endosomal compartment Würzburg : Universität Würzburg, 2016 Online-Ressource B:DE-101 application/pdf http://d-nb.info/1149302453/04 Inhaltsverzeichnis https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-139994 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030273748&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lyga, Sandra 1986- Glycoprotein hormone receptor signaling in the endosomal compartment = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment Signaltransduktion (DE-588)4318717-1 gnd G-Protein gekoppelter Rezeptor (DE-588)7723480-7 gnd Endosom (DE-588)4570819-8 gnd Cyclo-AMP (DE-588)4148493-9 gnd |
| subject_GND | (DE-588)4318717-1 (DE-588)7723480-7 (DE-588)4570819-8 (DE-588)4148493-9 (DE-588)4113937-9 |
| title | Glycoprotein hormone receptor signaling in the endosomal compartment = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment |
| title_alt | Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment |
| title_auth | Glycoprotein hormone receptor signaling in the endosomal compartment = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment |
| title_exact_search | Glycoprotein hormone receptor signaling in the endosomal compartment = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment |
| title_full | Glycoprotein hormone receptor signaling in the endosomal compartment = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment submitted by Sandra Lyga from Gießen |
| title_fullStr | Glycoprotein hormone receptor signaling in the endosomal compartment = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment submitted by Sandra Lyga from Gießen |
| title_full_unstemmed | Glycoprotein hormone receptor signaling in the endosomal compartment = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment submitted by Sandra Lyga from Gießen |
| title_short | Glycoprotein hormone receptor signaling in the endosomal compartment |
| title_sort | glycoprotein hormone receptor signaling in the endosomal compartment glykoproteinhormon rezeptor signaltransduktion im endosomalen kompartiment |
| title_sub | = Glykoproteinhormon-Rezeptor Signaltransduktion im endosomalen Kompartiment |
| topic | Signaltransduktion (DE-588)4318717-1 gnd G-Protein gekoppelter Rezeptor (DE-588)7723480-7 gnd Endosom (DE-588)4570819-8 gnd Cyclo-AMP (DE-588)4148493-9 gnd |
| topic_facet | Signaltransduktion G-Protein gekoppelter Rezeptor Endosom Cyclo-AMP Hochschulschrift |
| url | http://d-nb.info/1149302453/04 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-139994 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030273748&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lygasandra glycoproteinhormonereceptorsignalingintheendosomalcompartmentglykoproteinhormonrezeptorsignaltransduktionimendosomalenkompartiment AT lygasandra glykoproteinhormonrezeptorsignaltransduktionimendosomalenkompartiment |
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