Verfügbarkeit: The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data

The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data:

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Bibliographische Detailangaben
1. Verfasser:	Lukassen, Sören (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Erlangen ; Nürnberg 2018
Schlagworte:	Transponierbares Element Nachweis Geschlechtschromosom Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	VI, 107, xlii Seiten Illustrationen, Diagramme 21 cm

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MARC


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Datensatz im Suchindex

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adam_text	3 INTRODUCTION 1 3.1 SPERMATOGENESIS................................................................................................ 1 3.2 EPIGENETICS ...................................................................................................... 4 3.3 RETROTRANSPOSONS ............................................................................................ 8 3.4 SPO C 1............................................................................................................... 11 3.5 MEIOTIC SEX CHROMOSOME IN A CTIV ATIO N ........................................................... 13 4 RESULTS 16 4.1 CHIP-SEQ FOR SPOC1 IN MOUSE TE S T E S .......................................................... 17 4.2 TRANSCRIPTOME ANALYSIS OF SPOCL+/ +AND SPOOL / MOUSE T E S T E S .................. 30 4.3 METHYLATION ANALYSES OF LINE ELEM ENTS ....................................................... 40 4.4 SEQUENCING OF FULL-LENGTH LINE LI INSERTION SITE S........................................ 46 4.5 BIOINFORMATIC DETECTION OF TRANSPOSON INSERTION S ITE S .................................. 48 5 DISCUSSION 69 5.1 SPOC1 IN MSCI ............................................................................................ 69 5.2 SPOC1 AND M 6 A ............................................................................................ 74 5.3 TRANSPOSON REPRESSION ................................................................................... 77 5.4 SEQUENCING OF LI INSERTIONS IN THE MOUSE GENOME ..................................... 80 5.5 DETECTION OF TE-ASSOCIATED VARIANTS IN HUMAN EXOM ES ................................ 81 5.6 TE VULNERABILITY PREDICTION .......................................................................... 82 6 OUTLOOK 85 6.1 SPOC1, LINES, AND M S C I............................................................................. 85 6.2 TE IDENTIFICATION FROM WES D A T A ................................................................ 86 6.3 PREDICTION OF TE INSERTION LIKELIHOOD 86 7 MATERIAL AND METHODS 87 7.1 M A TE RIA L............................................................................................................ 88 7.2 M ETHODS............................................................................................................ 96 8 APPENDIX 8.1 SCRIPTS AND CODE 9 ABBREVIATIONS LIST OF FIGURES LIST OF TABLES 10 ACKNOWLEDGMENTS XII XIV XVI XVIII 11 BIBLIOGRAPHY XIX
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spelling	Lukassen, Sören Verfasser (DE-588)1177420376 aut The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data vorgelegt von Sören Lukassen Erlangen ; Nürnberg 2018 VI, 107, xlii Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2018 Transponierbares Element (DE-588)4319836-3 gnd rswk-swf Nachweis (DE-588)4115334-0 gnd rswk-swf Geschlechtschromosom (DE-588)4157012-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Transponierbares Element (DE-588)4319836-3 s Geschlechtschromosom (DE-588)4157012-1 s Nachweis (DE-588)4115334-0 s DE-604 B:DE-101 application/pdf http://d-nb.info/1171495757/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030760604&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Lukassen, Sören The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data Transponierbares Element (DE-588)4319836-3 gnd Nachweis (DE-588)4115334-0 gnd Geschlechtschromosom (DE-588)4157012-1 gnd
subject_GND	(DE-588)4319836-3 (DE-588)4115334-0 (DE-588)4157012-1 (DE-588)4113937-9
title	The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data
title_auth	The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data
title_exact_search	The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data
title_full	The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data vorgelegt von Sören Lukassen
title_fullStr	The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data vorgelegt von Sören Lukassen
title_full_unstemmed	The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data vorgelegt von Sören Lukassen
title_short	The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data
title_sort	the contribution of transposable elements to meiotic sex chromosome inactivation msci and their detection in whole exome sequencing data
topic	Transponierbares Element (DE-588)4319836-3 gnd Nachweis (DE-588)4115334-0 gnd Geschlechtschromosom (DE-588)4157012-1 gnd
topic_facet	Transponierbares Element Nachweis Geschlechtschromosom Hochschulschrift
url	http://d-nb.info/1171495757/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030760604&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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