Principles of evolutionary medicine:
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford
Oxford University Press
2016
|
| Ausgabe: | Second edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | xiv, 378 Seiten Illustrationen, Diagramme, Karten |
| ISBN: | 9780199663927 9780199663934 |
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| 650 | 7 | |a biological development |2 cabt | |
| 650 | 7 | |a gene flow |2 cabt | |
| 650 | 7 | |a selection pressure |2 cabt | |
| 650 | 7 | |a adaptation |2 cabt | |
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Datensatz im Suchindex
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| adam_text | Contents
PART 1 FUNDAMENTALS OF EVOLUTIONARY BIOLOGY
ft
1 Introduction 3
1.1 What is disease? 5
1.2 What evolution is: fundamental principles 8
1.3 Time 13
1.4 Constraints 15
1.5 We are not alone 15
1.6 Culture and gene-culture coevolution 16
1.7 How evolutionary arguments fit alongside other biological perspectives 16
1.8 Evolution and medicine 17
Key points 18
2 Evolutionary theory 19
2.1 Introduction 19
2.2 What does evolutionary theory explain? 21
2.3 How does evolution work? 24
2.4 Areas of debate and the limitations of the adaptationist argument 39
2.5 Conclusion 46
Key points 48
3 The molecular basis of variation and inheritance 49
3.1 Introduction 49
3.2 Genes and disease 49
3.3. The molecular basis of human genetic variation 50
3.4 Factors affecting genetic variation 59
3.5 Single-gene or Mendelian disorders 65
3.6 No single genes for common diseases 68
3.7 Epigenetic mechanisms as a cause of variation 71
3.8 Non-genetic inheritance 73
3.9 Conclusion 77
Key points 77
XI
CONTENTS
xti
4 Evolution and development 79
4.1 Introduction 79
4.2 Development: pre-ordained or plastic? 81
4.3 Is development important to evolution? 82
4.4 Developmental plasticity 84
4.5 Responses to environmental cues during development 86
4.6 Epigenetic processes and development 90
4.7 Learning and instinct 91
4.8 The evolution of novelty 93
4.9 Conclusion 94
Key points 96
5 The human life history 97
5.1 Introduction 97
5.2 General overview of life-history theory 98
5.3 Body size and shape 107
5.4 Growth in humans 113
5.5 Evolutionary analysis of the distinct features of human growth 124
5.6 Conclusion 127
Key points 129
6 Human evolution and the origins of human diversity 131
6.1 Introduction 131
6.2 The hominoid clade 131
6.3 Hominin evolution 132
6.4 Genomic changes that make us human 147
6.5 Human adaptation to local selection pressures 148
6.6 Are humans still evolving? 153
6.7 Social and medical implications of human diversity 155
6.8 Conclusion 157
Key points 158
PART 2 EVOLUTION IN HEALTH AND DISEASE
7 An evolutionary framework for understanding human health and disease 161
7.1 Introduction 161
7.2 Fundamental principles of evolutionary medicine 162
7.3 Why has evolution left our bodies vulnerable to disease? 165
7.4 An evolutionary classification of ultimate mechanisms
affecting disease risk 167
7.5 Testing hypotheses in evolutionary medicine 175
Key points 175
CONTENTS xiii
8 Reproduction 177
8.1 Introduction 177
8.2 Sexual reproduction 178
8.3 Why did sex evolve? 178
8.4 Sex determination 181
8.5 Reproductive strategies 182
8.6 Mate choice 183
8.7 Sexual differences in the human 186
8.8 Sex differences in morbidity and mortality 188
8.9 Human reproductive life cycle 190
8.10 Conclusion 203
Key points 204
9 Nutritional and metabolic adaptation 205
9.1 Introduction 205
9.2 Strategies for energy storage 206
9.3 Human diet: an evolutionary history 210
9.4 How can change in the environment increase disease risk? 218
9.5 Conclusion 235
Key points 236
10 Coevolution, infection, and immunity 237
10.1 Introduction 237
10.2 Coevolution 237
10.3 Humans and their associated species 238
10.4 The challenge of infectious disease 240
10.5 Pathogen emergence 241
10.6 Pathogen virulence and transmission 242
10.7 Host defenses 244
10.8 Public health measures 252
10.9 Vaccination 253
10.10 Antibiotics 255
10.11 Conclusion 258
Key points 258
11 Psychology and behavior 261
11.1 Introduction 261
11.2 Biological determinants of culture and behavior 261
11.3 Evolution of the human brain and behavior 263
11.4 Evolution of social behavior 264
11.5 Evolutionary perspectives on psychology 278
11.6 Evolutionary psychiatry 279
11.7 Conclusion 284
Key points 286
XIV
CONTENTS
12 Cancer 287
12.1 Introduction 287
12.2 Epidemiology of cancer 288
12.3 Ecology of cancer 289
12.4 The biology of cancer 290
12.5 Cancer in the light of evolutionary mechanisms 293
12.6 Implications of an evolutionary approach for the prevention
and treatment of cancer 299
12.7 Conclusion 302
Key points 302
13 Evolutionary principles applied to medical practice and public health 303
13.1 Introduction: Understanding health and disease from
an evolutionary perspective 303
13.2 Testing evolutionary hypotheses in medicine 305
13.3 Clinical examples 305
13.4 An evolutionarily mismatched or novel environment 305
13.5 Life-history-associated factors 311
13.6 Excessive and uncontrolled defense mechanisms 313
13.7 Consequences of coevolution with microbes 315
13.8 Results of evolutionary constraints 317
13.9 An apparently harmful allele is maintained by balancing selection 319
13.10 The consequences of sexual selection 321
13.11 The outcomes of cladal and demographic history 322
13.12 Value and limits of an evolutionary medicine perspective 324
Key points 326
14 Evolution, medicine, and society 327
14.1 Introduction 327
14.2 Origins of Darwin s theory 327
14.3 From Darwin to Social Darwinism 331
14.4 Eugenics 332
14.5 The Modern Synthesis/ human evolution, and medicine 335
14.6 Evolution, society and religion 337
14.7 Evolutionary thought and the human condition 339
Key points 339
References 341
Index 365
Evoluti
nised as a
r?
itical to an understanding of integrated human biology and is increasingly recog-
. ^discipline by medical and public health professionals. Advances in the field of genomics,
__ _ _ , __ «’ .
epigenetics, developmental biology, and epidemiology have led to the growing realisation that incorporating
evolutional
edition of th
u is essential for medicine to achieve its full potential. This revised and updated second
principles of evolutionary
i a medical perspective and focuses on how medicine and public health might utilise evolutionary
thinking. It is written to be accessible to a broad range of readers, whether or not they have had formal
a*»? ■}
exposure
science.
The general structure of the second edition remains unchanged, with the initial six chapters providing a
summary of the evolutionary theory relevant to understanding human health and disease, using examples
specifically relevant to medicine. The second part of the book describes the application of evolutionary
principles to understanding particular aspects of human medicine: in addition to updated chapters on repro-
duction, metabolism, and behaviour, there is an expanded chapter on our coexistence with micro-organisms
and an entirely new chapter on cancer. The two parts are bridged by a chapter that details pathways by
which evolutionary processes affect disease risk and symptoms, and how hypotheses in evolutionary medi
cine can be tested. The final two chapters of the volume are considerably expanded: they illustrate the
application of evolutionary biology to medicine and public health, and consider the ethical and societal issues
of an evolutionary perspective. A number of new clinical examples and historical illustrations are included.
This second edition of a novel and popular textbook provides an updated resource for doctors and other
health professionals, medical students and biomedical scientists, as well as anthropologists interested in
human health, to gain a better understanding of the evolutionary processes underlying human health
and disease.
ISBN 978-0-19-966392-7
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| spelling | Gluckman, Peter D. 1949- Verfasser (DE-588)135774470 aut Principles of evolutionary medicine Peter Gluckman, Alan Beedle, Tatjana Buklijas, Felicia Low, Mark Hanson Second edition Oxford Oxford University Press 2016 xiv, 378 Seiten Illustrationen, Diagramme, Karten txt rdacontent n rdamedia nc rdacarrier evolution cabt biological development cabt gene flow cabt selection pressure cabt adaptation cabt environmental factors cabt social behaviour cabt Genetik (DE-588)4071711-2 gnd rswk-swf Anthropologie (DE-588)4002230-4 gnd rswk-swf Evolutionsmedizin (DE-588)7718082-3 gnd rswk-swf Evolutionsbiologie (DE-588)4153283-1 gnd rswk-swf Evolutionsbiologie (DE-588)4153283-1 s DE-604 Genetik (DE-588)4071711-2 s Anthropologie (DE-588)4002230-4 s Evolutionsmedizin (DE-588)7718082-3 s 1\p DE-604 Beedle, Alan Verfasser aut Buklijas, Tatjana Verfasser aut Low, Felicia M. Verfasser aut Hanson, Mark A. 1949- Verfasser (DE-588)135774535 aut Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028778337&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028778337&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Gluckman, Peter D. 1949- Beedle, Alan Buklijas, Tatjana Low, Felicia M. Hanson, Mark A. 1949- Principles of evolutionary medicine evolution cabt biological development cabt gene flow cabt selection pressure cabt adaptation cabt environmental factors cabt social behaviour cabt Genetik (DE-588)4071711-2 gnd Anthropologie (DE-588)4002230-4 gnd Evolutionsmedizin (DE-588)7718082-3 gnd Evolutionsbiologie (DE-588)4153283-1 gnd |
| subject_GND | (DE-588)4071711-2 (DE-588)4002230-4 (DE-588)7718082-3 (DE-588)4153283-1 |
| title | Principles of evolutionary medicine |
| title_auth | Principles of evolutionary medicine |
| title_exact_search | Principles of evolutionary medicine |
| title_full | Principles of evolutionary medicine Peter Gluckman, Alan Beedle, Tatjana Buklijas, Felicia Low, Mark Hanson |
| title_fullStr | Principles of evolutionary medicine Peter Gluckman, Alan Beedle, Tatjana Buklijas, Felicia Low, Mark Hanson |
| title_full_unstemmed | Principles of evolutionary medicine Peter Gluckman, Alan Beedle, Tatjana Buklijas, Felicia Low, Mark Hanson |
| title_short | Principles of evolutionary medicine |
| title_sort | principles of evolutionary medicine |
| topic | evolution cabt biological development cabt gene flow cabt selection pressure cabt adaptation cabt environmental factors cabt social behaviour cabt Genetik (DE-588)4071711-2 gnd Anthropologie (DE-588)4002230-4 gnd Evolutionsmedizin (DE-588)7718082-3 gnd Evolutionsbiologie (DE-588)4153283-1 gnd |
| topic_facet | evolution biological development gene flow selection pressure adaptation environmental factors social behaviour Genetik Anthropologie Evolutionsmedizin Evolutionsbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028778337&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028778337&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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