Verfügbarkeit: Computing characterizations of drugs for ion channels and receptors using Markov models

Computing characterizations of drugs for ion channels and receptors using Markov models:

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Bibliographische Detailangaben
Hauptverfasser:	Tveito, Aslak (VerfasserIn), Lines, Glenn T. (VerfasserIn)
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	[Cham] Springer [2016]
Schriftenreihe:	Lecture Notes in Computational Science and Engineering 111
Schlagworte:	Mathematics Computer graphics Computer mathematics Computational Science and Engineering Biomedicine general Computer Imaging, Vision, Pattern Recognition and Graphics Mathematik
Online-Zugang:	DE-634 DE-898 DE-861 DE-91 DE-384 DE-19 DE-703 DE-20 DE-739 Volltext Inhaltsverzeichnis Abstract
Beschreibung:	1 Online-Ressource (XVI, 261 Seiten, 129 illus., 30 illus. in color)
ISBN:	9783319300306 9783319300290
ISSN:	1439-7358
DOI:	10.1007/978-3-319-30030-6

Internformat

MARC


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Datensatz im Suchindex

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adam_text	COMPUTING CHARACTERIZATIONS OF DRUGS FOR ION CHANNELS AND RECEPTORS USING MARKOV MODELS / TVEITO, ASLAK : 2016 TABLE OF CONTENTS / INHALTSVERZEICHNIS PREFACE BACKGROUND: CONTENTS AND METHOD ONE-DIMENSIONAL CALCIUM RELEASE MODELS OF OPEN AND STATE BLOCKERS TWO-DIMENSIONAL CALCIUM RELEASE COMPUTING THEORETICAL DRUGS IN THE TWO-DIMENSIONAL CASE GENERALIZED SYSTEMS CALCIUM-INDUCED CALCIUM RELEASE NUMERICAL RELEASE FOR CICR A PROTOTYPICAL MODEL OF AN ION CHANNEL INACTIVATED ION CHANNELS A SIMPLE MODEL OF THE SODIUM CHANNEL MUTATIONS AFFECTING THE MEAN OPEN TIME THE BURST MODE WHOLE SALE ACTION POTENTIALS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. COMPUTING CHARACTERIZATIONS OF DRUGS FOR ION CHANNELS AND RECEPTORS USING MARKOV MODELS / TVEITO, ASLAK : 2016 ABSTRACT / INHALTSTEXT FLOW OF IONS THROUGH VOLTAGE GATED CHANNELS CAN BE REPRESENTED THEORETICALLY USING STOCHASTIC DIFFERENTIAL EQUATIONS WHERE THE GATING MECHANISM IS REPRESENTED BY A MARKOV MODEL. THE FLOW THROUGH A CHANNEL CAN BE MANIPULATED USING VARIOUS DRUGS, AND THE EFFECT OF A GIVEN DRUG CAN BE REFLECTED BY CHANGING THE MARKOV MODEL. THESE LECTURE NOTES PROVIDE AN ACCESSIBLE INTRODUCTION TO THE MATHEMATICAL METHODS NEEDED TO DEAL WITH THESE MODELS. THEY EMPHASIZE THE USE OF NUMERICAL METHODS AND PROVIDE SUFFICIENT DETAILS FOR THE READER TO IMPLEMENT THE MODELS AND THEREBY STUDY THE EFFECT OF VARIOUS DRUGS. EXAMPLES IN THE TEXT INCLUDE STOCHASTIC CALCIUM RELEASE FROM INTERNAL STORAGE SYSTEMS IN CELLS, AS WELL AS STOCHASTIC MODELS OF THE TRANSMEMBRANE POTENTIAL. WELL KNOWN MARKOV MODELS ARE STUDIED AND A SYSTEMATIC APPROACH TO INCLUDING THE EFFECT OF MUTATIONS IS PRESENTED. LASTLY, THE BOOK SHOWS HOW TO DERIVE THE OPTIMAL PROPERTIES OF A THEORETICAL MODEL OF A DRUG FOR A GIVEN MUTATION DEFINED IN TERMS OF A MARKOV MODEL DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spellingShingle	Tveito, Aslak Lines, Glenn T. Computing characterizations of drugs for ion channels and receptors using Markov models Lecture Notes in Computational Science and Engineering Mathematics Computer graphics Computer mathematics Computational Science and Engineering Biomedicine general Computer Imaging, Vision, Pattern Recognition and Graphics Mathematik
title	Computing characterizations of drugs for ion channels and receptors using Markov models
title_auth	Computing characterizations of drugs for ion channels and receptors using Markov models
title_exact_search	Computing characterizations of drugs for ion channels and receptors using Markov models
title_full	Computing characterizations of drugs for ion channels and receptors using Markov models Aslak Tveito, Glenn T. Lines
title_fullStr	Computing characterizations of drugs for ion channels and receptors using Markov models Aslak Tveito, Glenn T. Lines
title_full_unstemmed	Computing characterizations of drugs for ion channels and receptors using Markov models Aslak Tveito, Glenn T. Lines
title_short	Computing characterizations of drugs for ion channels and receptors using Markov models
title_sort	computing characterizations of drugs for ion channels and receptors using markov models
topic	Mathematics Computer graphics Computer mathematics Computational Science and Engineering Biomedicine general Computer Imaging, Vision, Pattern Recognition and Graphics Mathematik
topic_facet	Mathematics Computer graphics Computer mathematics Computational Science and Engineering Biomedicine general Computer Imaging, Vision, Pattern Recognition and Graphics Mathematik
url	https://doi.org/10.1007/978-3-319-30030-6 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028961640&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028961640&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
volume_link	(DE-604)BV022396727
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