Diagnosis, verification and dosimetry of exposure to nerve agents: analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition
Gespeichert in:
| Hauptverfasser: | , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Bonn
Fachinformationszentrum der Bundeswehr
2005
|
| Ausgabe: | Als Ms. gedr. |
| Schriftenreihe: | Forschungsbericht aus der Wehrmedizin
[20]05,3 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Getr. Zählung graph. Darst. |
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| 100 | 1 | |a Schans, M. J. van der |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Diagnosis, verification and dosimetry of exposure to nerve agents |b analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition |c Bearb.: M. J. van der Schans ; J. P. Langenberg |
| 246 | 1 | 1 | |a Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition |
| 250 | |a Als Ms. gedr. | ||
| 264 | 1 | |a Bonn |b Fachinformationszentrum der Bundeswehr |c 2005 | |
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| 490 | 1 | |a Forschungsbericht aus der Wehrmedizin |v [20]05,3 | |
| 700 | 1 | |a Langenberg, J. P. |e Verfasser |4 aut | |
| 830 | 0 | |a Forschungsbericht aus der Wehrmedizin |v [20]05,3 |w (DE-604)BV000068183 |9 2005,3 | |
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Datensatz im Suchindex
| _version_ | 1804133411896426496 |
|---|---|
| adam_text | Contents
Summary 2
Acknowledgements 5
Introduction 7
Experimental part 13
Materials 13
Methods 13
In vivo exposure of marmosets to nerve agents 22
Results 23
Analysis of inhibited and aged BuChE 23
Analysis of hydrolysis products 44
In vivo exposure of monkeys to nerve agents 50
Analysis of hydrolysis products in urine of monkeys administered with nerve agent....52
Analysis of protein from plasma samples of monkeys administered with nerve agent..58
Biomonitoring of marmosets exposed to parathion and sarin 60
Application of the pepsin digestion method 62
Discussion 65
Development of a method for biomonitoring of aged nerve agent inhibited BuChE
(technical objective 1) 66
Measurement of aged nerve agent inhibited BuChE in plasma from rhesus monkey
(technical objective 2) 67
Optimization of a method to analyze hydrolyzed sarin, soman, cyclohexyl sarin and
VX (technical objective 3) 69
Measurement of hydrolyzed OP compounds in urine of rhesus monkeys (technical
objective 4) 70
Additional in vivo experiments with rhesus monkeys (technical objective 5) 72
Study of the selectivity of the diagnosis/dosimetric verification method for nerve
agents in the rhesus monkey (technical objective 6) 73
Conclusions 76
List of Abbreviations 78
References 79
Signature 85
Appendices
A Amino acid sequence of BuChE
B Mass spectra of phosphylated BuChE digests
C Results of fluoride reactivation assay in rhesus monkeys
D GC MS chromatograms
E Blood sampling and urine collection marmoset experiments
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| any_adam_object | 1 |
| author | Schans, M. J. van der Langenberg, J. P. |
| author_facet | Schans, M. J. van der Langenberg, J. P. |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T20:08:18Z |
| institution | BVB |
| language | English |
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| series | Forschungsbericht aus der Wehrmedizin |
| series2 | Forschungsbericht aus der Wehrmedizin |
| spelling | Schans, M. J. van der Verfasser aut Diagnosis, verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition Bearb.: M. J. van der Schans ; J. P. Langenberg Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition Als Ms. gedr. Bonn Fachinformationszentrum der Bundeswehr 2005 Getr. Zählung graph. Darst. txt rdacontent n rdamedia nc rdacarrier Forschungsbericht aus der Wehrmedizin [20]05,3 Langenberg, J. P. Verfasser aut Forschungsbericht aus der Wehrmedizin [20]05,3 (DE-604)BV000068183 2005,3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013205989&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schans, M. J. van der Langenberg, J. P. Diagnosis, verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition Forschungsbericht aus der Wehrmedizin |
| title | Diagnosis, verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition |
| title_alt | Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition |
| title_auth | Diagnosis, verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition |
| title_exact_search | Diagnosis, verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition |
| title_full | Diagnosis, verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition Bearb.: M. J. van der Schans ; J. P. Langenberg |
| title_fullStr | Diagnosis, verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition Bearb.: M. J. van der Schans ; J. P. Langenberg |
| title_full_unstemmed | Diagnosis, verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition Bearb.: M. J. van der Schans ; J. P. Langenberg |
| title_short | Diagnosis, verification and dosimetry of exposure to nerve agents |
| title_sort | diagnosis verification and dosimetry of exposure to nerve agents analysis of protein bound phosphyl moieties and of hydrolysis products final methoden zur retrospektiven diagnose und verifikation einer nervenkampfstoffexposition |
| title_sub | analysis of protein bound phosphyl moieties and of hydrolysis products (final) = Methoden zur retrospektiven Diagnose und Verifikation einer Nervenkampfstoffexposition |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013205989&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000068183 |
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