Mathematical Modelling of Chromosome Replication and Replicative Stress:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2015
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| Schriftenreihe: | Springer Theses
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| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9783319088617 |
| DOI: | 10.1007/978-3-319-08861-7 |
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Datensatz im Suchindex
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|---|---|
| adam_text | MATHEMATICAL MODELLING OF CHROMOSOME REPLICATION AND REPLICATIVE STRESS
/ KARSCHAU, JENS
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
OPTIMAL ORIGIN PLACEMENT FOR MINIMAL REPLICATION TIME
ACTIVELY REPLICATING DOMAINS RANDOMLY ASSOCIATE INTO REPLICATION
FACTORIES
SUMMARY AND CONCLUSIONS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
MATHEMATICAL MODELLING OF CHROMOSOME REPLICATION AND REPLICATIVE STRESS
/ KARSCHAU, JENS
: 2015
ABSTRACT / INHALTSTEXT
DNA REPLICATION IS ARGUABLY THE MOST CRUCIAL PROCESS AT WORK IN LIVING
CELLS. IT IS THE MECHANISM BY WHICH ORGANISMS PASS THEIR GENETIC
INFORMATION FROM ONE GENERATION TO THE NEXT, AND LIFE ON EARTH WOULD BE
UNTHINKABLE WITHOUT IT. DESPITE THE DISCOVERY OF DNA STRUCTURE IN THE
1950S, THE MECHANISM OF ITS REPLICATION REMAINS RATHER ELUSIVE. THIS
WORK MAKES IMPORTANT CONTRIBUTIONS TO THIS LINE OF RESEARCH. IN
PARTICULAR, IT ADDRESSES TWO KEY QUESTIONS IN THE AREA OF DNA
REPLICATION: WHICH EVOLUTIONARY FORCES DRIVE THE POSITIONING OF
REPLICATION ORIGINS IN THE CHROMOSOME; AND HOW IS THE SPATIAL
ORGANIZATION OF REPLICATION FACTORIES ACHIEVED INSIDE THE NUCLEUS OF A
CELL? A CROSS-DISCIPLINARY APPROACH UNITING PHYSICS AND BIOLOGY IS AT
THE HEART OF THIS RESEARCH. ALONG WITH EXPERIMENTAL SUPPORT, STATISTICAL
PHYSICS THEORY PRODUCES OPTIMAL ORIGIN POSITIONS AND PROVIDES A MODEL
FOR REPLICATION FORK ASSEMBLY IN YEAST. ADVANCES MADE HERE CAN
POTENTIALLYFURTHER OUR UNDERSTANDING OFDISEASE MECHANISMSSUCH AS
THE ABNORMAL REPLICATION IN CANCER
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Karschau, Jens Verfasser aut Mathematical Modelling of Chromosome Replication and Replicative Stress Jens Karschau Cham [u.a.] Springer 2015 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Springer Theses Zugl.: Aberdeen, Univ., Diss. Genetic engineering Nucleic acids Physics (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Druckausgabe 978-3-319-08860-0 https://doi.org/10.1007/978-3-319-08861-7 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027680466&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027680466&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Karschau, Jens Mathematical Modelling of Chromosome Replication and Replicative Stress Genetic engineering Nucleic acids Physics |
| subject_GND | (DE-588)4113937-9 |
| title | Mathematical Modelling of Chromosome Replication and Replicative Stress |
| title_auth | Mathematical Modelling of Chromosome Replication and Replicative Stress |
| title_exact_search | Mathematical Modelling of Chromosome Replication and Replicative Stress |
| title_full | Mathematical Modelling of Chromosome Replication and Replicative Stress Jens Karschau |
| title_fullStr | Mathematical Modelling of Chromosome Replication and Replicative Stress Jens Karschau |
| title_full_unstemmed | Mathematical Modelling of Chromosome Replication and Replicative Stress Jens Karschau |
| title_short | Mathematical Modelling of Chromosome Replication and Replicative Stress |
| title_sort | mathematical modelling of chromosome replication and replicative stress |
| topic | Genetic engineering Nucleic acids Physics |
| topic_facet | Genetic engineering Nucleic acids Physics Hochschulschrift |
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