Verfügbarkeit: The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction

The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction: = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit

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Bibliographische Detailangaben
1. Verfasser:	Kalinichenko, Liubov 1988- (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Erlangen ; Nürnberg Friedrich-Alexander-Universität Erlangen-Nürnberg 2018
Schlagworte:	Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	156 Seiten Illustrationen, Diagramme 30 cm

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adam_text	TABLE OF CONTENTS TABLE OF CONTENTS ABBREVIATIONS ABSTRACT ....................................................................................................................... 1 ZUSAMMENFASSUNG................................................................................................... 3 1. IN TR O D U C TIO N ......................................................................................................... 5 1.1. MAJOR DEPRESSIVE DISORDER.......................................................................................5 1.1.1. ALTERATION OF NEUROTRANSMITTER HOMEOSTASIS ..................................................... 6 1.1.2. HPA/STRESS HYPOTHESIS.......................................................................................12 1.1.3. NEURODEGENERATIVE HYPOTHESIS......................................................................... 13 1.1.4. CYTOKINE/INFLAMMATORY HYPOTHESIS ................................................................... 15 1.2. ALCOHOL USE DISORDER ........................................................................................... 17 1.1.1. ALTERATION OF NEUROTRANSMITTER HOMEOSTASIS ................................................... 18 1.1.2. HPA/STRESS HYPOTHESIS ...................................................................................... 25 1.1.3. NEURODEGENERATIVE HYPOTHESIS ......................... 26 1.1.4. CYTOKINE/INFLAMMATORY HYPOTHESIS................................................................... 27 1.3. INTERACTION BETWEEN ALCOHOL CONSUMPTION AND DEPRESSION. DRUG INSTRUMENTALIZATION..........................................................................................................28 1.4. CERAMIDE/ACID SPHINGOMYELINASE SYSTEM IN PSYCHIATRIC DISORDERS .............. 32 1.4.1. STRUCTURE AND BIOLOGICAL PROPERTIES OF LIPIDS...................................................32 1.4.2. STRUCTURE AND BIOLOGICAL PROPERTIES OF SPHINGOLIPIDS .................................... 33 1.4.2.1. STRUCTURE OF SPHINGOLIPIDS...............................................................................33 1.4.2 2. LIPID RAFTS........................................................................................................... 36 1.4.2.3. INVOLVEMENT OF CERAMIDE/ACID SPHINGOMYELINASE SYSTEM IN THE PATHOGENESIS OF MAJOR DEPRESSIVE DISORDER .............................................................. 38 1.4.2.3. INVOLVEMENT OF CERAMIDE/ACID SPHINGOMYELINASE SYSTEM IN THE PATHOGENESIS OF ALCOHOL USE DISORDER.........................................................................41 1.5. AIM OF THE STUDY...................................................................................................... 45 2. MATERIALS AND M ETHODS ................................................................................ 46 2.1. ANIMALS................................................................................................................ 46 2.2. EXPERIMENTAL DESIGN.............................................................................................. 46 2.3. METHODS.................................................................................................................... 48 2.3.1. FREE-CHOICE ALCOHOL CONSUMPTION .................................................................. 48 2.3.2. FORCED ALCOHOL EXPOSURE................................................................................... 49 2.3.3. BEHAVIORAL TESTING................................................................................................ 49 2.3.4. ACID SPHINGOMYELINASE ACTIVITY......................................................................... 51 2.3.5. POST MORTEM NEUROCHEMISTRY.............................................................................52 2.3.6. IN VIVO MICRODIALYSIS.............................................................................................53 2.3.9. LOSS OF RIGHTING REFLEX......................................................................................... 55 2.3.10. BLOOD ALCOHOL DETERMINATION ........................................................................... 55 2.4. STATISTICAL ANALYSIS................................................................................................ 55 3. RESULTS.....................................................................................................................57 3.1. ENHANCED ALCOHOL CONSUMPTION IN MICE WITH HYPERACTIVITY OF ACID SPHINGOMYELINASE...........................................................................................................57 3.2. FREE-CHOICE ALCOHOL DRINKING RESTORES HOMEOSTASIS OF ACID SPHINGOMYELINASE AND REVERSES DEPRESSION-LIKE BEHAVIOR IN ASMTG M ICE ........ 60 3.3. NO ANTIDEPRESSANT EFFECTS OF FORCED ALCOHOL EXPOSURE IN ASMTG M ICE ........ 66 3.4. FORCED ETHANOL TREATMENT ENHANCED DEPRESSION- AND ANXIETY-LIKE BEHAVIOR IN MICE WITH HYPOFUNCTION OF ACID SPHINGOMYELINASE ............................................. 71 3.5. ALCOHOL DRINKING RESTORES MONOAMINE LEVELS IN ASMTG M ICE.........................76 3.6. ACTIVITY OF ACID SPHINGOMYELINASE CONTRIBUTES TO DOPAMINERGIC AND NORADRENERGIC ACTIVATION AFTER ACUTE ALCOHOL TREATMENT ........................................... 80 3.7. ACTIVITY OF ACID SPHINGOMYELINASE DOES NOT CONTROL ALCOHOLS SEDATING EFFECTS................................................................................................................................ 94 3.8. ACTIVITY OF ACID SPHINGOMYELINASE ACTIVITY DOES NOT CONTROL ALCOHOLS BIOAVAILABILITY....................................................................................................................95 4. DISC U SSIO N ..............................................................................................................96 5. REFERENCES..........................................................................................................108 ACKNOW LEDGMENTS.............................................................................................. 151 CURRICULUM V ITA E ................................................................................................. 152 SUPPLEMENTARY M ATERIALS.............................................................................155
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author	Kalinichenko, Liubov 1988-
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spelling	Kalinichenko, Liubov 1988- Verfasser (DE-588)1160736030 aut The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit vorgelegt von Liubov Kalinichenko Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit Erlangen ; Nürnberg Friedrich-Alexander-Universität Erlangen-Nürnberg 2018 156 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1160735603/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030419202&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Kalinichenko, Liubov 1988- The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit
subject_GND	(DE-588)4113937-9
title	The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit
title_alt	Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit
title_auth	The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit
title_exact_search	The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit
title_full	The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit vorgelegt von Liubov Kalinichenko
title_fullStr	The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit vorgelegt von Liubov Kalinichenko
title_full_unstemmed	The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction = Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit vorgelegt von Liubov Kalinichenko
title_short	The role of acid sphingomyelinase in depression/anxiety-induced alcohol addiction
title_sort	the role of acid sphingomyelinase in depression anxiety induced alcohol addiction die rolle der sauren sphingomyelinase bei depressions und angst assoziierter alkoholabhangigkeit
title_sub	= Die Rolle der sauren Sphingomyelinase bei Depressions- und Angst-assoziierter Alkoholabhängigkeit
topic_facet	Hochschulschrift
url	http://d-nb.info/1160735603/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030419202&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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