The effect of cognitive remediation on event related potentials in schizophrenia:
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
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Wuppertal
August 2015
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| Online-Zugang: | The effect of cognitive remediation on event related potentials in schizophrenia Inhaltsverzeichnis |
| Beschreibung: | iv, 179 Seiten Diagramme |
Internformat
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| 245 | 1 | 0 | |a The effect of cognitive remediation on event related potentials in schizophrenia |c by Christian Kärgel |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENT
1 CHAPTER 1: SCHIZOPHRENIA, COGNITION AND ELECTROPHYSIOLOGY
...........
1
1.1 HISTORICAL
BACKROUND...........................................................................................
2
1.2 DIAGNOSTIC
CRITERIA................................................................................................2
1.3
EPIDEMIOLOGY........................................................................................................
3
1.4 ETIOLOGICAL
MODELS................................................................................................4
1.4.1 NEUROTRANSMITTER ABNORMALITIES
.........................................................
4
1.4.2
GENETICS...............................................................................................5
1.4.3 NEUROPHYSIOLOGICAL DISRUPTIONS
...........................................................
6
1.5 COGNITIVE IMPAIRMENTS
......................................................................................
6
1.6
ELECTROENCEPHALOGRAPHY.....................................................................................
7
1.7 EVENT-RELATED
POTENTIALS.....................................................................................
9
1.7.1 MISMATCH NEGATIVITY (MMN)
..............................................................
10
1.7.2
N100...................................................................................................
12
1.7.3
P200...................................................................................................
13
1.7.4
P300...................................................................................................
15
1.8 COGNITIVE TRAINING IN SCHIZOPHRENIA
................................................................
16
1.8.1 COMPUTERIZED COGNITIVE
TRAINING........................................................18
1.8.2 META-ANALYSES OF COGNITIVE TRAINING STUDIES IN SCHIZOPHRENIA
...........
19
1.8.3 AUDITORY TRAINING AND COGNITIVE
FUNCTIONING.......................................25
1.8.4 NEUROPHYSIOLOGICAL MECHANISMS UNDERLYING AUDITORY TRAINING
..........
26
1.8.5 EFFECT OF COGNITIVE TRAINING ON ERPS
...................................................
27
1.8.6 RELEVANCE OF THE PRESENT STUDY
.........................................................
28
1.9 COGNITIVE TRAINING
29
1.9.1 AUDITORY DISCRIMINATION TRAINING
29
1.9.2 VISUAL SPATIAL ATTENTION
TRAINING.......................................................... 30
1.10 OUTLINE OF THE
THESIS...........................................................................................31
1.10.1 STUDY 1
...............................................................................................32
1.10.2 STUDY 2
...............................................................................................36
1.10.3 STUDY 3
...............................................................................................
37
2 CHAPTER 2: MISMATCH NEGATIVITY LATENCY AND COGNITIVE FUNCTIONING
IN
SCHIZOPHRENIA.........................................................................................
39
2.1
ABSTRACT...............................................................................................................
40
2.2
INTRODUCTION........................................................................................................
41
2.3 M
ETHODS..............................................................................................................
44
2.3.1
PARTICIPANTS........................................................................................44
2.3.2 MMN
STIMULI......................................................................................46
2.3.3 EEG
RECORDINGS...................................................................................
46
2.3.4 DATA
PREPROCESSING............................................................................
47
2.3.5 CLINICAL INTERVIEWS AND NEUROPHYSIOLOGICAL MEASURES
........................
47
2.3.6 STATISTICAL
ANALYSES.............................................................................
48
2.4
RESULTS.................................................................................................................
49
2.4.1 NEUROPSYCHOLOGICAL TESTS
...................................................................
49
2.4.2 MISMATCH
NEGATIVITY..........................................................................
51
2.4.3 RELATIONS BETWEEN VARIABLES
..............................................................
55
2.5
DISCUSSION............................................................................................................56
3 CHAPTER 3: THE EFFECT OF COGNITIVE TRAINING ON THE MISMATCH
NEGATIVITY IN SCHIZOPHRENIA
......................................................................
62
3.1
ABSTRACT................................................................................................................63
3.2 INTRODUCTION
64
3.3 M
ETHODS..............................................................................................................67
3.3.1
PARTICIPANTS........................................................................................67
3.3.2
TREATMENT..........................................................................................69
3.3.3 AUDITORY TRAINING
(AUD).....................................................................
69
3.3.4 VISUAL SPATIAL TRAINING
(VIS)................................................................ 70
3.3.5 MMN STIMULI..................................... 71
3.3.6 EEG
RECORDING....................................................................................71
3.3.7 DATA
PROCESSING.................................................................................72
3.3.8 CLINICAL INTERVIEWS AND NEUROPSYCHOLOGICAL MEASURES
.......................
72
3.3.9 STATISTICAL
ANALYSES.............................................................................73
3.4
RESULTS.................................................................................................................
74
3.5
DISCUSSION...........................................................................................................
79
4 CHAPTER 4: THE EFFECT OF COGNITIVE TRAINING ON EVOKED POTENTIALS IN
SCHIZOPHRENIA.............................................................................................
84
4.1
ABSTRACT...............................................................................................................85
4.2
INTRODUCTION........................................................................................................86
4.3 M
ETHODS..............................................................................................................87
4.3.1
PARTICIPANTS........................................................................................87
4.3.2
DESIGN...............................................................................................
88
4.3.3 COGNITIVE TRAINING (BOX
1.1)............................................................... 88
4.3.4 EVOKED
POTENTIALS..............................................................................89
4.3.5 CLINICAL
INTERVIEWS..............................................................................90
4.3.6 STATISTICAL
ANALYSES.............................................................................91
4.4
RESULTS.................................................................................................................
91
4.4.1
ERPS....................................................................................................94
4.4.2 NEUROPSYCHOLOGICAL VARIABLES
............................................................
98
4.4.3 RELATIONS BETWEEN VARIABLES
..............................................................
99
4.5
DISCUSSION...........................................................................................................
100
5 CHAPTER 5
:
GENERAL DISCUSSION
........................................................
103
5.1 CHARACTERISTICS OFT THE PRESENT SAMPLE
........................................................
104
5.2 ERP DIFFERENCES BETWEEN CONTROLS AND SCHIZOPHRENIA PATIENTS
...............
105
5.3 EFFECTS OF COGNITIVE TRAINING ON
ERPS............................................................106
5.3.1 TREATMENT EFFECTS ON THE MMN AND P200 COMPNENT
......................
106
5.3.2 ABSENCE OF AUDITORY TREATMENT
EFFECTS............................................109
5.4 EFFECTS OF COGNITIVE TRAINING ON NEUROPSYCHOLOGICAL MEASURES
...............
110
5.4.1 EFFECTS OF AUDITORY TRAINING ON
COGNITION...........................................113
5.5 EFFECTS OF COGNITIVE TRAINING ON CLINICAL AND PSYCHO-SOCIAL RATINGS
..........
117
5.6 ASSOCIATIONS BETWEEN ERPS AND CLINICAL
RATINGS.........................................118
5.7 ASSOCIATIONS BETWEEN ERPS AND NEUROPSYCHOLOGY
....................................
120
5.8 INTEGRATION OF THE PRESENT FINDINGS
..............................................................
121
5.9
LIMITATIONS.........................................................................................................124
5.10
OUTLOOK..............................................................................................................
125
5.11
SUMMARY...........................................................................................................125
6
REFERENCES........................................................................................................128
7 TABLES AND
FIGURES...........................................................................................
166
APPENDIX.................................................................................................................169
|
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| spelling | Kärgel, Christian 1980- Verfasser (DE-588)1106414454 aut The effect of cognitive remediation on event related potentials in schizophrenia by Christian Kärgel Wuppertal August 2015 iv, 179 Seiten Diagramme txt rdacontent n rdamedia nc rdacarrier Dissertation Bergische Universität Wuppertal 2015 Kognition (DE-588)4031630-0 gnd rswk-swf Training (DE-588)4060595-4 gnd rswk-swf Schizophrenie (DE-588)4052527-2 gnd rswk-swf Elektroencephalographie (DE-588)4014254-1 gnd rswk-swf Neurobiologie (DE-588)4041871-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Schizophrenie (DE-588)4052527-2 s Kognition (DE-588)4031630-0 s Training (DE-588)4060595-4 s Neurobiologie (DE-588)4041871-6 s Elektroencephalographie (DE-588)4014254-1 s DE-604 http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=6832085&custom_att_2=simple_viewer The effect of cognitive remediation on event related potentials in schizophrenia Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029109888&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kärgel, Christian 1980- The effect of cognitive remediation on event related potentials in schizophrenia Kognition (DE-588)4031630-0 gnd Training (DE-588)4060595-4 gnd Schizophrenie (DE-588)4052527-2 gnd Elektroencephalographie (DE-588)4014254-1 gnd Neurobiologie (DE-588)4041871-6 gnd |
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| title | The effect of cognitive remediation on event related potentials in schizophrenia |
| title_auth | The effect of cognitive remediation on event related potentials in schizophrenia |
| title_exact_search | The effect of cognitive remediation on event related potentials in schizophrenia |
| title_full | The effect of cognitive remediation on event related potentials in schizophrenia by Christian Kärgel |
| title_fullStr | The effect of cognitive remediation on event related potentials in schizophrenia by Christian Kärgel |
| title_full_unstemmed | The effect of cognitive remediation on event related potentials in schizophrenia by Christian Kärgel |
| title_short | The effect of cognitive remediation on event related potentials in schizophrenia |
| title_sort | the effect of cognitive remediation on event related potentials in schizophrenia |
| topic | Kognition (DE-588)4031630-0 gnd Training (DE-588)4060595-4 gnd Schizophrenie (DE-588)4052527-2 gnd Elektroencephalographie (DE-588)4014254-1 gnd Neurobiologie (DE-588)4041871-6 gnd |
| topic_facet | Kognition Training Schizophrenie Elektroencephalographie Neurobiologie Hochschulschrift |
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