Natural lactones and lactams: synthesis, occurrence and biological activity
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Sprache: | English |
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Wiley-VCH
2014
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Beschreibung: | XVI, 376 S. graph. Darst. 244 mm x 170 mm |
ISBN: | 3527334149 9783527334148 |
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245 | 1 | 0 | |a Natural lactones and lactams |b synthesis, occurrence and biological activity |c ed. by Tomasz Janecki |
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CONTENTS
PREFACE XIII
LIST OF CONTRIBUTORS XV
1 TETRONIC ACIDS 1
DIMITRIS GEORGIADIS
1.1 INTRODUCTION 1
1.2 NATURAL OCCURRENCE, BIOLOGICAL ACTIVITIES, AND BIOSYNTHESIS 1
1.3 5-YLIDENE TETRONIC NATURAL PRODUCTS 6
1.3.1 PULVINIC ACIDS AND PULVI'RIONES 6
1.3.2 AGGLOMERINS 11
1.3.3 TETRONOMYCIN 13
1.3.4 STEMOFOLINE ALKALOIDS 13
1.3.5 VARIABILIN 17
1.3.6 TETRODECAMYCIN 17
1.4 5-MONOSUBSTITUTED TETRONIC NATURAL PRODUCTS 19
1.4.1 CARLIC, CARLOSIC, CAROLIC, CAROLINIC, AND VIRIDICATIC ACIDS 19
1.4.2 RK-682 20
1.4.3 MASSARILACTONE B 21
1.4.4 ANNULARINS F, G, AND H 21
1.4.5 PALINURIN 23
1.4.6 PESTHETOXIN 24
1.4.7 ROTUNDIFOLIDES A AND B 24
1.5 5-DISUBSTITUTED TETRONIC NATURAL PRODUCTS 25
1.5.1 5-DIALKYL TETRONIC NATURAL PRODUCTS 25
1.5.1.1 VERTINOLIDE 25
1.5.1.2 PAPYRACILLIC ACID B 26
1.5.1.3 BISORBIBUTENOLIDE 26
1.5.2 5-SPIROTETRONIC NATURAL PRODUCTS 29
1.5.2.1 SPIROTETRONIC ANTIBIOTICS 29
1.5.2.2 IRCINIANIN AND WISTARIN 35
1.5.2.3 STEMONAMINE ALKALOIDS 35
1.5.2.4 ABYSSOMICINS 37
1.6 5-UNSUBSTITUTED TETRONIC NATURAL PRODUCTS 41
HTTP://D-NB.INFO/1033857793
VII
CONTENTS
1.6.1 TETRONASIN 41
1.7 CONCLUSIONS 42
REFERENCES 43
2 RECENT ADVANCES IN THE FIELD OF NATURALLY OCCURRING
5,6-DIHYDROPYRAN-2-ONES 51
JUAN ALBERTO MARCO AND MIGUEL CARDA
2.1 INTRODUCTION 51
2.2 SYNTHETIC METHODOLOGIES FOR 5,6-DIHYDROPYRAN-2-ONES 52
2.2.1 LACTONIZATION OF SUBSTITUTED 8-HYDROXY ACID DERIVATIVES 52
2.2.2 OXIDATION OF SUBSTITUTED DIHYDROPYRAN DERIVATIVES 53
2.2.3 RING-CLOSING METATHESIS 54
2.2.4 MISCELLANEOUS METHODS 54
2.3 FORMATION OF STEREOGENIC CENTERS INSIDE THE DIHYDROPYRONE RING 55
2.3.1 USE OF CHIRAL PRECURSORS 56
2.3.1.1 CARBOHYDRATE AND RELATED PRECURSORS 56
2.3.1.2 CHIRAL HYDROXY ACIDS 58
2.3.1.3 CHIRAL EPOXIDES 60
2.3.1.4 OTHER CHIRONS 62
2.3.2 ASYMMETRIC (ENANTIOSELECTIVE) REACTIONS 64
2.3.2.1 ASYMMETRIC (ENANTIOSELECTIVE) SHARPLESS EPOXIDATIONS OR
DIHYDROXYLATIONS 64
2.3.2.2 ASYMMETRIC ALDOL-TYPE REACTIONS 68
2.3.2.3 ASYMMETRIC ALLYLATIONS 69
2.3.2.4 ASYMMETRIC CARBONYL REDUCTIONS 71
2.3.2.5 ASYMMETRIC ALKYLATIONS 72
2.3.2.6 ASYMMETRIC EPOXIDE HYDROLYSIS 73
2.3.2.7 ASYMMETRIC CYDOADDITIONS 74
2.3.2.8 OTHER ASYMMETRIC METHODS 75
2.4 PHARMACOLOGICAL PROPERTIES OF PYRONES 78
2.5 BIOSYNTHETIC FORMATION OF PYRONES 79
2.6 SYNTHESES OF NATURAL 5,6-DIHYDROPYRAN-2-ONES REPORTED DURING
THE PERIOD FROM 2006 TO THE FIRST HALF OF 2012 91
REFERENCES 91
3 ^-LACTAMS 101
GIRIJA S. SINGH AND SIJI SUDHEESH
3.1 INTRODUCTION 101
3.1.1 BIOSYNTHESIS OF PENICILLIN AND CEPHALOSPORIN 102
3.2 MONOCYCLIC P-LACTAMS 103
3.2.1 BIOSYNTHESIS OF NOCARDICIN A 104
3.2.2 SYNTHETIC APPROACHES TO CONSTRUCT P-LACTAM RING 105
3.2.2.1 CYCLOADDITION REACTIONS 106
3.2.2.2 CYCLIZATION REACTIONS 115
3.2.2.3 MISCELLANEOUS APPROACHES 118
CONTENTS VII
3.2.3 BIOLOGICAL ACTIVITY OF MONOCYCLIC 2-AZETIDINONES 119
3.3 PENAMS 121
3.3.1 SYNTHETIC APPROACHES TO PENAM SKELETON 121
3.3.2 BIOLOGICAL ACTIVITY OF PENAMS 122
3.4 CEPHALOSPORINS 124
3.4.1 SYNTHETIC APPROACHES TO CEPHALOSPORIN SKELETON 125
3.4.2 BIOLOGICAL ACTIVITY OF CEPHALOSPORINS 128
3.5 CLAVULANIC ACID 130
3.5.1 SYNTHETIC APPROACHES TO CLAVAM SKELETON 131
3.5.2 BIOLOGICAL ACTIVITY OF CLAVAMS 132
3.6 CARBAPENEMS 133
3.6.1 SYNTHETIC APPROACHES TO CARBAPENEM SKELETON 134
3.6.2 BIOLOGICAL ACTIVITY OF CARBAPENEMS 136
3.7 SPIRO-FUSED (5-LACTAMS 137
3.7.1 OCCURRENCE AND STRUCTURE OF CHARTELLINES 137
3.7.2 TOTAL SYNTHESIS OF CHARTELLINE C 137
3.7.3 BIOLOGICAL ACTIVITY OF SPIRO-FUSED FS-LACTAMS 140
3.8 SUMMARY 140
REFERENCES 141
4 A-ALKYLIDENE-Y- AND 8-LACTONES AND LACTAMS 147
LUKASZ ALBRECHT, ANNA ALBRECHT, AND TOMASZ JANECKI
4.1 INTRODUCTION 147
4.2 OCCURRENCE, BIOSYNTHESIS, AND BIOLOGICAL ACTIVITIES OF A-ALKYLIDENE
Y- AND 8-LACTONES AND LACTAMS 148
4.2.1 A-ALKYLIDENE-Y-LACTONES 148
4.2.2 A-ALKYLIDENE-8-LACTONES 152
4.2.3 CT-ALKYLIDENE-Y- AND 5-LACTAMS 153
4.3 RECENT ADVANCES IN THE SYNTHESIS OF A-ALKYLIDENE-Y- AND 8-LACTONES
AND LACTAMS 153
4.3.1 CYCLIZATION OF 2-ALKYLIDENE-4-(5-)HYDROXYALKANOATES AND
2-ALKYLIDENE-4-(5-)AMINOALKANOATES IN THE SYNTHESIS OF
A-ALKYLIDENE-Y- AND
8-LACTONES AND LACTAMS 154
4.3.1.1 ORGANOMETALLIC REAGENTS DERIVED FROM 2-BROMOMETHYLACRYLIC ACID
AND ITS DERIVATIVES IN THE SYNTHESIS OF 2-ALKYLIDENE-
4-HYDROXYALKANOATES AND 2-ALKYLIDENE-4-AMINOALKANOATES
155
4.3.1.2 APPLICATION OF ALLYLBORONATES IN THE SYNTHESIS OF 2-ALKYLIDENE-
4-HYDROXYALKANOATES AND 2-ALKYLIDENE-4-AMINOALKANOATES 156
4.3.1.3 BAYLIS-HILLMAN ALCOHOL DERIVATIVES IN THE SYNTHESIS OF
A-ALKYLIDENE
Y- AND 8-LACTONES AND LACTAMS 161
4.3.1.4 RING-OPENING REACTIONS IN THE SYNTHESIS OF 2-ALKYLIDENE-
4-HYDROXYALKANOATES AND 4-AMINOALKANOATES 167
4.3.2 CONSTRUCTION OF OT-ALKYLIDENE-Y- AND 8-LACTONE AND LACTAM
RINGS VIA INTRAMOLECULAR MORITA-BAYLIS-HILLMAN
REACTION 168
VIIII
CONTENTS
4.3.3 METHODS INVOLVING A-DIALKOXYPHOSPHORYL-Y- AND 8-LACTONES AND
LACTAMS AS KEY INTERMEDIATES 172
4.3.3.1 METHODS INVOLVING CYCLIC A,P-UNSATURATED
PRECURSORS 172
4.3.3.2 METHODS INVOLVING 2-DIALKOXYPHOSPHORYL 4-(5-)HYDROXY OR
4-(5-)AMINOALKANOATES AS KEY INTERMEDIATES 174
4.3.3.3 A-DIETHOXYPHOSPHORYL-8-LACTONES IN THE SYNTHESIS OF
3-METHYLENE-3,4-DIHYDROCOUMARINS 182
4.3.3.4 ANNULATION OF THE LACTONE FRAMEWORKS VIA CARBON-CARBON
BOND-FORMING REACTIONS 184
4.3.4 (3-ELIMINATION REACTION IN THE SYNTHESIS OF
A-ALKYLIDENE-Y-LACTONES
OR Y-LACTAMS 184
4.3.5 OXIDATION OF 3-ALKYLIDENETETRAHYDROFURANONES IN THE SYNTHESIS OF
A-ALKYLIDENE-Y-LACTONES 186
4.3.6 MISCELLANEOUS METHODS FOR THE PREPARATION OF CT-ALKYLIDENELACTONES
AND LACTAMS 187
4.4 CONCLUSIONS 188
REFERENCES 188
5 MEDIUM-SIZED LACTONES 193
ISAMU SHIINA AND KENYA NAKATA
5.1 INTRODUCTION 193
5.1.1 NATURAL EIGHT-AND NINE-MEMBERED LACTONES 193
5.1.2 LACTONIZATION METHODS 194
5.1.2.1 COREY-NICOLAOU S-PYRIDYL ESTER LACTONIZATION METHOD 195
5.1.2.2 MUKAIYAMA ONIUM SALT METHOD 195
5.1.2.3 MASAMUNE THIOESTER ACTIVATION METHOD 197
5.1.2.4 YAMAGUCHI MIXED-ANHYDRIDE METHOD 198
5.1.2.5 MITSUNOBU ALCOHOL ACTIVATION METHOD 199
5.1.2.6 KECK-STEGLICH DCC/DMAP-HC1 ACTIVATION METHOD 199
5.1.2.7 SHIINA BENZOIC ANHYDRIDE METHOD 200
5.2 TOTAL SYNTHESIS OF EIGHT-MEMBERED LACTONES 203
5.2.1 CEPHALOSPOROLIDE D 203
5.2.1.1 SHIINA TOTAL SYNTHESIS (1988) 203
5.2.1.2 BUSZEK TOTAL SYNTHESIS (2001) 204
5.2.1.3 RAO TOTAL SYNTHESIS (2010) 204
5.2.1.4 SABITHA TOTAL SYNTHESIS (2011) 205
5.2.2 OCTALACTINS A AND B 205
5.2.2.1 BUSZEK TOTAL SYNTHESIS (1994) 205
5.2.2.2 CLARDY TOTAL SYNTHESIS (1994) 206
5.2.2.3 HOLMES TOTAL SYNTHESIS (2004) 207
5.2.2.4 SHIINA TOTAL SYNTHESIS (2004) 207
5.2.2.5 ANDRUS FORMAL TOTAL SYNTHESIS (1996) 208
5.2.2.6 HATAKEYAMA SYNTHESIS OF THE LACTONE MOIETY (1998) 209
5.2.2.7 GARCIA SYNTHESIS OF THE LACTONE MOIETY (1998) 210
CONTENTS
IIX
5.2.2.8 BUSZEK ALTERNATIVE SYNTHESIS OF OCTALACTIN A (2002) 210
5.2.2.9 COSSY SYNTHESIS OF THE LACTONE MOIETY (2005) 211
5.2.2.10 HULME PARTIAL SYNTHESIS (1997) 211
5.2.3 SOLANDELACTONES A-H 212
5.2.3.1 MARTIN TOTAL SYNTHESIS OF SOLANDELACTONE E (2007) 212
5.2.3.2 WHITE TOTAL SYNTHESIS OF SOLANDELACTONES E AND F (2007) 213
5.2.3.3 PIETRUSZKA,TOTAL SYNTHESIS OF SOLANDELACTONES A-H (2008) 213
5.2.3.4 AGGARWAL TOTAL SYNTHESIS OF SOLANDELACTONES E (2010) AND
F (2012) 214
5.2.3.5 DATTA SYNTHESIS OF THE LACTONE MOIETY (1988) 214
5.2.3.6 MOHAPATRA SYNTHESIS OF THE LACTONE MOIETY (2003) 215
5.3 TOTAL SYNTHESIS OF NINE-MEMBERED LACTONES 215
5.3.1 HALICOLACTONE 215
5.3.1.1 WILLS TOTAL SYNTHESIS (1995) 216
5.3.1.2 TAKEMOTO-TANAKA TOTAL SYNTHESIS (2000) 216
5.3.1.3 KITAHARA TOTAL SYNTHESIS (2002) 216
5.3.1.4 TANG TOTAL SYNTHESIS (2009) 217
5.3.1.5 PIETRUSZKA TOTAL SYNTHESIS (2010) 218
5.3.1.6 DATTA FORMAL SYNTHESIS (1998) 218
5.3.2 GRISEOVIRIDIN 219
5.3.2.1 MEYERS TOTAL SYNTHESIS (2000) 219
5.3.3 2-EPIBOTCINOLIDE 219
5.3.3.1 SHIINA TOTAL SYNTHESIS (2006) 220
5.3.3.2 CHAKRABORTY SYNTHESIS OF THE LACTONE MOIETY (2006) 222
5.4 CONCLUSIONS 222
REFERENCES 223
6 MACROLACTONES 229
GANGAVARAM V. M. SHARMA AND VENKATA RAMANA DODDI
6.1 INTRODUCTION 229
6.1.1 CLASSIFICATION OF MACROLIDES 231
6.1.1.1 "POLYOXO" MACROLIDES 232
6.1.1.2 POLYENE MACROLIDES 232
6.1.1.3 IONOPHORIC MACROLIDES 233
6.1.1.4 ANSAMYCIN MACROLIDES 233
6.1.1.5 OTHER MACROLIDES 234
6.1.2 MACROLACTONES AS CHEMICAL SIGNALS (SEMIOCHEMICALS) 235
6.1.3 MACROLACTONES AS MUSKS 236
6.2 GENERAL METHODS FOR THE SYNTHESIS OF MACROLACTONES 236
6.3 SYNTHESIS OF MACROLIDES 241
6.3.1 SYNTHESIS OF PATULOLIDE C 241
6.3.2 SYNTHESIS OF BALTICOLIDE 242
6.3.3 SYNTHESIS OF OXIMIDINE II 243
6.3.4 SYNTHESIS OF RIPOSTATIN B 245
6.3.5 SYNTHESIS OF AZAMACROLIDES 247
X | CONTENTS
6.3.6 SYNTHESIS OF (+)-ACUTIPHYCIN 247
6.3.7 SYNTHESIS OF ARCHAZOLID A 250
6.3.8 SYNTHESIS OF EPOTHILONE B 251
6.3.9 SYNTHESIS OF BATATOSIDE L 252
6.4 SYNTHESIS OF MACRODIOLIDES 252
6.4.1 SYNTHESIS OF VERBALACTONE 254
6.4.2 SYNTHESIS OF ACREMODIOL 255
6.4.3 SYNTHESIS OF AMPHIDINOLIDE X 257
6.4.4 SYNTHESIS OF MARINOMYCIN A 258
6.5 SYNTHESIS OF MACROTRIOLIDES 260
6.5.1 SYNTHESIS OF MACROSPHELIDES A AND E 261
6.5.2 SYNTHESIS OF MACROSPHELIDES C AND F 262
6.5.3 SYNTHESIS OF MACROSPHELIDES G AND I 263
6.5.4 SYNTHESIS OF MACROSPHELIDE M 266
6.6 CONCLUSIONS AND PERSPECTIVES 267
ABBREVIATIONS 267
REFERENCES 269
7 RESORCYLIC ACID LACTONES 273
CARMELA NAPOLITANO AND PAUL V. MURPHY
7.1 INTRODUCTION - A HISTORICAL PERSPECTIVE 273
7.2 BIOSYNTHESIS 277
7.3 CHEMICAL SYNTHESIS 277
7.3.1 ZEARALENONE 279
7.3.2 RADICICOL 285
7.3.3 POCHONINS 292
7.3.4 RALS WITH CIS-ENONE GROUPS 295
7.3.5 AIGIALOMYCIN D 303
7.3.6 OTHER RALS 309
7.4 CONCLUSION AND OUTLOOK 315
REFERENCES 315
8 CYCLIC PEPTIDES 321
SRINIVASA RAO ADUSUMALLI, ANDREI K. YUDIN, AND VISHAL RAI
8.1 INTRODUCTION 321
8.2 SYNTHESIS OF NATURAL LACTONES AND LACTAMS 332
8.2.1 CYCLOCINAMIDE A 332
8.2.2 BIPHENOMYCIN B 333
8.2.3 ANTILLATOXIN 336
8.2.4 HALIPEPTINS 338
8.2.5 LARGAZOLE 340
8.2.6 DENDROAMIDE A 342
8.2.7 CHONDRAMIDE C 346
8.2.8 CYCLOCITROPSIDES 346
8.2.9 SANGUINAMIDE B 349
8.2.10 APRATOXIN A 349
8.2.11 THIOCILLIN I 351
8.2.12 LAGUNAMIDE A 353
8.2.13 KAPAKAHINES 356
8.2.14 CHLOPTOSIN 357
8.3 CONCLUSION 359
REFERENCES 361
INDEX 371 |
any_adam_object | 1 |
author2 | Janecki, Tomasz |
author2_role | edt |
author2_variant | t j tj |
author_GND | (DE-588)1043874151 |
author_facet | Janecki, Tomasz |
building | Verbundindex |
bvnumber | BV041342126 |
classification_rvk | VK 5500 VK 7300 VK 8500 VK 8800 |
classification_tum | CHE 649f CHE 670f CHE 548f |
ctrlnum | (OCoLC)863647575 (DE-599)DNB1033857793 |
dewey-full | 547.59 540 |
dewey-hundreds | 500 - Natural sciences and mathematics |
dewey-ones | 547 - Organic chemistry 540 - Chemistry and allied sciences |
dewey-raw | 547.59 540 |
dewey-search | 547.59 540 |
dewey-sort | 3547.59 |
dewey-tens | 540 - Chemistry and allied sciences |
discipline | Chemie / Pharmazie Chemie |
format | Book |
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genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
genre_facet | Aufsatzsammlung |
id | DE-604.BV041342126 |
illustrated | Illustrated |
indexdate | 2024-09-10T01:01:45Z |
institution | BVB |
isbn | 3527334149 9783527334148 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026790875 |
oclc_num | 863647575 |
open_access_boolean | |
owner | DE-11 DE-91S DE-BY-TUM DE-19 DE-BY-UBM |
owner_facet | DE-11 DE-91S DE-BY-TUM DE-19 DE-BY-UBM |
physical | XVI, 376 S. graph. Darst. 244 mm x 170 mm |
publishDate | 2014 |
publishDateSearch | 2014 |
publishDateSort | 2014 |
publisher | Wiley-VCH |
record_format | marc |
spelling | Natural lactones and lactams synthesis, occurrence and biological activity ed. by Tomasz Janecki Weinheim Wiley-VCH 2014 XVI, 376 S. graph. Darst. 244 mm x 170 mm txt rdacontent n rdamedia nc rdacarrier Lactame (DE-588)4166366-4 gnd rswk-swf Lactone (DE-588)4166378-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lactone (DE-588)4166378-0 s Lactame (DE-588)4166366-4 s DE-604 Janecki, Tomasz (DE-588)1043874151 edt text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4304432&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026790875&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Natural lactones and lactams synthesis, occurrence and biological activity Lactame (DE-588)4166366-4 gnd Lactone (DE-588)4166378-0 gnd |
subject_GND | (DE-588)4166366-4 (DE-588)4166378-0 (DE-588)4143413-4 |
title | Natural lactones and lactams synthesis, occurrence and biological activity |
title_auth | Natural lactones and lactams synthesis, occurrence and biological activity |
title_exact_search | Natural lactones and lactams synthesis, occurrence and biological activity |
title_full | Natural lactones and lactams synthesis, occurrence and biological activity ed. by Tomasz Janecki |
title_fullStr | Natural lactones and lactams synthesis, occurrence and biological activity ed. by Tomasz Janecki |
title_full_unstemmed | Natural lactones and lactams synthesis, occurrence and biological activity ed. by Tomasz Janecki |
title_short | Natural lactones and lactams |
title_sort | natural lactones and lactams synthesis occurrence and biological activity |
title_sub | synthesis, occurrence and biological activity |
topic | Lactame (DE-588)4166366-4 gnd Lactone (DE-588)4166378-0 gnd |
topic_facet | Lactame Lactone Aufsatzsammlung |
url | http://deposit.dnb.de/cgi-bin/dokserv?id=4304432&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026790875&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT janeckitomasz naturallactonesandlactamssynthesisoccurrenceandbiologicalactivity |