Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response:
The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase acti...
Gespeichert in:
| 1. Verfasser: | |
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| Weitere Verfasser: | , , , , , , , , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2021
|
| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.18 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase activity to suppress many kinds of immune functions and have been used in the medical domain to prevent hyper immune reactions. However, CNIs are reported to also induce immunosuppression-derived adverse effects such as increased frequency and/or severity of infections and increased tumor incidences. CNIs might affect several T-cell derived immune functions to induce compromised host. Among the affected immune functions, T-cell dependent antibody response (TDAR) is an important factor to resist infections and thought to be the useful endpoint on evaluating immunotoxicity of chemicals; therefore, this AOP describes the linkage between the inhibition of CN activity and impairment of TDAR. |
| Beschreibung: | 1 Online-Ressource (61 p.) |
| DOI: | 10.1787/3c988dde-en |
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| 520 | |a The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase activity to suppress many kinds of immune functions and have been used in the medical domain to prevent hyper immune reactions. However, CNIs are reported to also induce immunosuppression-derived adverse effects such as increased frequency and/or severity of infections and increased tumor incidences. CNIs might affect several T-cell derived immune functions to induce compromised host. Among the affected immune functions, T-cell dependent antibody response (TDAR) is an important factor to resist infections and thought to be the useful endpoint on evaluating immunotoxicity of chemicals; therefore, this AOP describes the linkage between the inhibition of CN activity and impairment of TDAR. | ||
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| author | Komatsu, Hiroyuki |
| author2 | Sugimoto, Junichiro Goto, Ken Kushima, Kiyoshi Tsutsui, Naohisa Hisada, Shigeru Ito, Shiho Kosaka, Tadashi Ohishi, Takumi Otsubo, Yasuharu Takahashi, Yoshihiro |
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| author_facet | Komatsu, Hiroyuki Sugimoto, Junichiro Goto, Ken Kushima, Kiyoshi Tsutsui, Naohisa Hisada, Shigeru Ito, Shiho Kosaka, Tadashi Ohishi, Takumi Otsubo, Yasuharu Takahashi, Yoshihiro |
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| discipline | Wirtschaftswissenschaften |
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| indexdate | 2024-07-16T15:07:03Z |
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| series2 | OECD Series on Adverse Outcome Pathways |
| spelling | Komatsu, Hiroyuki VerfasserIn aut Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Hiroyuki, Komatsu ... [et al] Paris OECD Publishing 2021 1 Online-Ressource (61 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OECD Series on Adverse Outcome Pathways no.18 The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase activity to suppress many kinds of immune functions and have been used in the medical domain to prevent hyper immune reactions. However, CNIs are reported to also induce immunosuppression-derived adverse effects such as increased frequency and/or severity of infections and increased tumor incidences. CNIs might affect several T-cell derived immune functions to induce compromised host. Among the affected immune functions, T-cell dependent antibody response (TDAR) is an important factor to resist infections and thought to be the useful endpoint on evaluating immunotoxicity of chemicals; therefore, this AOP describes the linkage between the inhibition of CN activity and impairment of TDAR. Environment Social Issues/Migration/Health Sugimoto, Junichiro MitwirkendeR ctb Goto, Ken MitwirkendeR ctb Kushima, Kiyoshi MitwirkendeR ctb Tsutsui, Naohisa MitwirkendeR ctb Hisada, Shigeru MitwirkendeR ctb Ito, Shiho MitwirkendeR ctb Kosaka, Tadashi MitwirkendeR ctb Ohishi, Takumi MitwirkendeR ctb Otsubo, Yasuharu MitwirkendeR ctb Takahashi, Yoshihiro MitwirkendeR ctb FWS01 ZDB-13-SOC FWS_PDA_SOC https://doi.org/10.1787/3c988dde-en Volltext |
| spellingShingle | Komatsu, Hiroyuki Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Environment Social Issues/Migration/Health |
| title | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_auth | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_exact_search | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_full | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Hiroyuki, Komatsu ... [et al] |
| title_fullStr | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Hiroyuki, Komatsu ... [et al] |
| title_full_unstemmed | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Hiroyuki, Komatsu ... [et al] |
| title_short | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_sort | adverse outcome pathway on inhibition of calcineurin activity leading to impaired t cell dependent antibody response |
| topic | Environment Social Issues/Migration/Health |
| topic_facet | Environment Social Issues/Migration/Health |
| url | https://doi.org/10.1787/3c988dde-en |
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