New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy:
From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract...
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| Weitere Verfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
2004
|
| Schriftenreihe: | Ernst Schering Foundation Symposium Proceedings
46 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted |
| Beschreibung: | 1 Online-Ressource (XVI, 214 p. 94 illus., 12 illus. in color) |
| ISBN: | 9783662053867 |
| DOI: | 10.1007/978-3-662-05386-7 |
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| 520 | |a From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted | ||
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| spelling | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy edited by K. S. Korach, A. Hillisch, K. H. Fritzemeier Berlin, Heidelberg Springer Berlin Heidelberg 2004 1 Online-Ressource (XVI, 214 p. 94 illus., 12 illus. in color) txt rdacontent c rdamedia cr rdacarrier Ernst Schering Foundation Symposium Proceedings 46 From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted Pharmacology/Toxicology Endocrinology Molecular Medicine Medical Biochemistry Toxicology Medicine Biochemistry Östrogene (DE-588)4075616-6 gnd rswk-swf Östrogenrezeptor (DE-588)4172467-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2003 Berlin gnd-content Östrogenrezeptor (DE-588)4172467-7 s DE-604 Östrogene (DE-588)4075616-6 s Korach, K. S. edt Hillisch, A. edt Fritzemeier, K. H. edt Erscheint auch als Druck-Ausgabe 9783662053881 Erscheint auch als Druck-Ausgabe 9783540402503 Erscheint auch als Druck-Ausgabe 9783662053874 https://doi.org/10.1007/978-3-662-05386-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy Pharmacology/Toxicology Endocrinology Molecular Medicine Medical Biochemistry Toxicology Medicine Biochemistry Östrogene (DE-588)4075616-6 gnd Östrogenrezeptor (DE-588)4172467-7 gnd |
| subject_GND | (DE-588)4075616-6 (DE-588)4172467-7 (DE-588)1071861417 |
| title | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy |
| title_auth | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy |
| title_exact_search | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy |
| title_full | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy edited by K. S. Korach, A. Hillisch, K. H. Fritzemeier |
| title_fullStr | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy edited by K. S. Korach, A. Hillisch, K. H. Fritzemeier |
| title_full_unstemmed | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy edited by K. S. Korach, A. Hillisch, K. H. Fritzemeier |
| title_short | New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy |
| title_sort | new molecular mechanisms of estrogen action and their impact on future perspectives in estrogen therapy |
| topic | Pharmacology/Toxicology Endocrinology Molecular Medicine Medical Biochemistry Toxicology Medicine Biochemistry Östrogene (DE-588)4075616-6 gnd Östrogenrezeptor (DE-588)4172467-7 gnd |
| topic_facet | Pharmacology/Toxicology Endocrinology Molecular Medicine Medical Biochemistry Toxicology Medicine Biochemistry Östrogene Östrogenrezeptor Konferenzschrift 2003 Berlin |
| url | https://doi.org/10.1007/978-3-662-05386-7 |
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