Basic pharmacology: understanding drug actions and reactions
Written as an introductory pharmacology text, Basic Pharmacology: Understanding Drug Actions and Reactions provides the in-depth discussion of the chemical and molecular pharmacology fundamentals that pharmacy students require to move on to more advanced study. The book covers the principles of chem...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC press
2006
|
| Schriftenreihe: | CRC press pharmacy education series
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | Written as an introductory pharmacology text, Basic Pharmacology: Understanding Drug Actions and Reactions provides the in-depth discussion of the chemical and molecular pharmacology fundamentals that pharmacy students require to move on to more advanced study. The book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. It emphasizes the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and interactions. The book effectively explains chemical and molecular pharmacology principles with extensive use of model drug molecules. (Midwest). |
| Beschreibung: | XVII, 369 S. Ill., graph. Darst. |
| ISBN: | 1587161605 9781587161605 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV021552202 | ||
| 003 | DE-604 | ||
| 005 | 20140721 | ||
| 007 | t | ||
| 008 | 060418s2006 ad|| |||| 00||| eng d | ||
| 020 | |a 1587161605 |9 1-58716-160-5 | ||
| 020 | |a 9781587161605 |9 978-1-58716-160-5 | ||
| 035 | |a (OCoLC)300272236 | ||
| 035 | |a (DE-599)BVBBV021552202 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-19 | ||
| 050 | 0 | |a RM300 | |
| 084 | |a VT 5010 |0 (DE-625)147739: |2 rvk | ||
| 100 | 1 | |a Hernandez, Maria A. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Basic pharmacology |b understanding drug actions and reactions |c Maria A. Hernandez ; Appu Rathinavelu |
| 264 | 1 | |a Boca Raton [u.a.] |b CRC press |c 2006 | |
| 300 | |a XVII, 369 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a CRC press pharmacy education series | |
| 520 | 3 | |a Written as an introductory pharmacology text, Basic Pharmacology: Understanding Drug Actions and Reactions provides the in-depth discussion of the chemical and molecular pharmacology fundamentals that pharmacy students require to move on to more advanced study. The book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. It emphasizes the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and interactions. The book effectively explains chemical and molecular pharmacology principles with extensive use of model drug molecules. (Midwest). | |
| 650 | 4 | |a Absorption - Acide - Action - Administration - Base - Biopharmaceutique - Cancer - Chimique - Distribution - Enzyme | |
| 650 | 4 | |a Excretion - Gaba - Inhibition - Interaction - Mecanisme - Medicament - Medication - Metabolisme - Pharmacodynamique - Pharmacologie | |
| 650 | 4 | |a Propriete - Reaction - Recepteur - Regulation - Signal - Traitement | |
| 650 | 4 | |a Pharmacologie | |
| 700 | 1 | |a Rathinavelu, Appu |e Verfasser |0 (DE-588)1053951671 |4 aut | |
| 856 | 4 | 2 | |m GBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014768257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-014768257 | ||
Datensatz im Suchindex
| _version_ | 1804135308922454016 |
|---|---|
| adam_text | BASIC PHARMACOLOGY UNDERSTANDING DRUG ACTIONS AND REACTIONS MARIA A.
HERNANDEZ PH.D. PHARMACEUTICAL AND ADMINISTRATIVE COLLEGE OF PHARMACY
NOVA SOUTHEASTERN UNIVERSITY FT. LAUDERDALE, FLORIDA, U.S.A. APPU
RATHINAVELU PH.D. PHARMACEUTICAL AND ADMINISTRATIVE COLLEGE OF PHARMACY
NOVA SOUTHEASTERN UNIVERSITY FT. LAUDERDALE, FLORIDA, U.S.A. (FIFTY)
TAYLOR & FRANCIS V^ J TAYLOR & FRANCIS CROUP BOCA RATON LONDON NEW YORK
A CRC TITLE, PART OF THE TAYLOR & FRANCIS IMPRINT, A MEMBER OF THE
TAYLOR & FRANCIS CROUP, THE ACADEMIC DIVISION OF T&F INFORMA PIC.
CONTENTS SECTION I PHYSICOCHEMICAL PROPERTIES OF DRUGS 1 FUNDAMENTAL
CHEMICAL PROPERTIES OF DRUGS 3 INTRODUCTION 3 THE PERIODIC TABLE AND
PROPERTIES OF DRUGS 3 THE PERIODIC TABLE AND CHEMICAL REACTIVITY 10
CHEMICAL BONDS 16 MAGNITUDE OF IONIC CHARGE 18 POLYATOMIC IONS 19
COVALENT BONDS 20 COORDINATE COVALENT BONDS 25 RESONANCE STRUCTURES *.
27 SHAPES OF DRUG MOLECULES 28 ELECTRONEGATIVITY 33 POLARITY OF CHEMICAL
BONDS 33 MOLECULAR POLARITY 34 FURTHER READING 35 2 ACID-BASE PROPERTIES
OF DRUGS 37 HYDROLYSIS OF SALTS , 38 CONJUGATE ACIDS AND CONJUGATE BASES
41 STRENGTH OF ACIDS AND BASES 43 RESONANCE AND INDUCTIVE EFFECTS 47
INDUCTIVE EFFECTS 47 RESONANCE EFFECTS 49 THE HENDERSON-HASSELBACH
EQUATION 53 FURTHER READING 60 3 STRUCTURAL DETERMINANTS OF DRUG ACTION
61 STRUCTURALLY NONSPECIFIC DRUGS 6L VOLATILE ANESTHETICS 61
STRUCTURALLY SPECIFIC DRUGS 63 ISOSTERISM AND ISOSTERES 68 STRUCTURAL
CHANGES IN DRUG MOLECULES 71 FURTHER READING 76 XI XII * BASIC
PHARMACOLOGY: UNDERSTANDING DRUG ACTIONS AND REACTIONS 4 CHEMICAL
APPROACHES TO THE TREATMENT OF CANCER 77 NORMAL VS. MALIGNANT CELLS 77
CELL CYCLE AND CHEMOTHERAPY 78 FROM CHEMICAL WARFARE TO CHEMOTHERAPY 79
ANTICANCER DRUGS 80 ALKYLATING AGENTS 81 ANTIMETABOLITES 84 DNA
INTERCALATORS 87 DNA CROSSLINKING AGENTS 89 FURTHER READING 90 SECTION
II PRINCIPLES OF BIOPHARMACEUTICS 5 ADMINISTRATION AND ABSORPTION OF
DRUGS 93 DRUG ADMINISTRATION 93 PROPERTIES OF THE DRUG 94 DRUG
SOLUBILITY 94 POLYMORPHISM 97 PARTICLE SIZE 98 PK 98 THERAPEUTIC
OBJECTIVE 100 ONSET OF ACTION 100 LONG-TERM ADMINISTRATION 100
RESTRICTION TO A LOCAL SITE 101 DRUG ABSORPTION 101 PHYSIOLOGICAL AND
PHYSICOCHEMICAL FACTORS IN DRUG ABSORPTION 103 DRUG TRANSPORT ACROSS
MEMBRANES 103 PASSIVE DIFFUSION 103 ACTIVE TRANSPORT 104 FACILITATED
TRANSPORT 104 ION PAIR TRANSPORT 105 ENDOCYTOSIS, PINOCYTOSIS,
PHAGOCYTOSIS, AND EXOCYTOSIS 105 PH OF BODY COMPARTMENTS 105 OTHER
FACTORS THAT AFFECT ABSORPTION 107 BLOOD FLOW TO THE ABSORPTION SITE 107
SURFACE AREA AVAILABLE FOR ABSORPTION 108 CONTACT TIME AT THE ABSORPTION
SURFACE 108 DRUG ABSORPTION, BIOAVAILABILITY, AND FIRST-PASS METABOLISM
108 FURTHER READING 110 6 DISTRIBUTION AND EXCRETION OF DRUGS ILL
FACTORS IN DRUG DISTRIBUTION ILL CAPILLARY PERMEABILITY 112 BLOOD
PERFUSION 114 PERFUSION AND PERMEABILITY 114 DRUG STRUCTURE AND
COMPARTMENT PH 116 PLASMA PROTEIN BINDING 116 INTRACELLULAR BINDING 117
CONTENTS * XIII PATTERNS OF DISTRIBUTION 117 DETERMINATION OF THE VOLUME
OF DISTRIBUTION 120 CLEARANCE AND ELIMINATION RATE 122 CLEARANCE AND THE
MAINTENANCE DOSE RATE 122 HALF-LIFE AND THE STEADY STATE 125
BIOAVAILABILITY 127 DRUG ELIMINATION 130 THE ENTEROHEPATIC CYCLE 130
RENAL EXCRETION 131 RENAL PROCESSES 132 FURTHER READING 133 7 METABOLIC
CHANGES OF DRUGS 135 CYTOCHROMES P450 136 INHIBITION OF DRUG METABOLISM
138 INDUCTION OF DRUG METABOLISM 138 ENVIRONMENTAL AND GENETIC FACTORS
IN METABOLISM BY CYP450 139 CLOZAPINE AND CYP1A2 ACTIVITY 142 GENETIC
POLYMORPHISM AND CYP2D6 142 CYP2D6 AND CODEINE 143 GENETIC POLYMORPHISM
AND CYP2C19 143 DRUG INTERACTIONS VIA THE CYP2C19 ISOFORM:
OMEPRAZOLE-DIAZEPAM INTERACTION 143 CYP3A FAMILY 143 CYP3A4 AND
GRAPEFRUIT JUICE 144 REDOX REACTIONS AND THE CYP450 ENZYME COMPLEX 144
NADVNADH SYSTEM 145 FAD/FADH SYSTEM 147 THE CYTOCHROME P45O CYCLE 147
PHASE I AND PHASE II REACTIONS OF DRUG METABOLISM 149 PHASE I REACTIONS
149 OXIDATIONS USING CYP450 ENZYMES 149 OXIDATION USING OTHER ENZYMES
163 REDUCTION 166 HYDROLYSIS REACTIONS 167 PHASE II REACTIONS
(CONJUGATION) 171 DOSE-DEPENDENT TOXICITY OF ACETAMINOPHEN 178 FURTHER
READING 186 SECTION III PRINCIPLES OF DRUG-RECEPTOR AND DRUG-ENZYME
INTERACTIONS 8 DRUG RECEPTORS AND PHARMACODYNAMICS 189 MECHANISMS OF
DRUG ACTION 189 CHEMICAL SIGNALING AND RECEPTOR FUNCTION 189 CHEMICAL
SIGNALING 189 AUTOCRINE, PARACRINE, AND ENDOCRINE FUNCTION 192 NATURE OF
THE SIGNALING MOLECULES (LIGANDS) 192 XIV * BASIC PHARMACOLOGY:
UNDERSTANDING DRUG ACTIONS AND REACTIONS DIFFERENT KINDS OF RECEPTORS
194 EXTRACELLULAR RECEPTORS 196 INTRACELLULAR RECEPTORS ; 196 PLASMA
MEMBRANE-BOUND RECEPTORS 196 THREE TYPES OF PLASMA MEMBRANE-BOUND
RECEPTORS 196 MODELS OF DRUG-RECEPTOR INTERACTION 198 DRUG-RECEPTOR
INTERACTIONS 198 KEY FEATURES OF BINDING SITES 198 LOCK-AND-KEY FIT 198
INDUCED FIT 199 AFFINITY AND INTRINSIC ACTIVITY 200 AFFINITY 200
INTRINSIC ACTIVITY 200 AGONISTS, ANTAGONISTS, AND PARTIAL AGONISTS 201
AGONISTS 201 ANTAGONISTS 201 PARTIAL AGONIST 201 LIGAND STRUCTURE AND
ACTIVITY RELATIONSHIP 201 WHY IS THE RECEPTOR CONCEPT IMPORTANT? 202
DIFFERENTIAL EFFECTS OF AGONISTS 202 DIFFERENTIAL EFFECTS OF EPINEPHRINE
202 SELECTIVE ACTIONS OF ADRENERGIC AGONISTS AND ANTAGONISTS 205
ATYPICAL RECEPTORS 208 CHOLINERGIC NEUROTRANSMISSION 209 SYNTHESIS AND
RELEASE OF ACETYLCHOLINE 210 DIFFERENTIAL EFFECTS OF ACETYLCHOLINE
THROUGH CHOLINERGIC RECEPTORS... 211 MUSCARINIC AND NICOTINIC ACTIONS OF
ACETYLCHOLINE 212 THE LOCATION AND FUNCTION OF ACETYLCHOLINE RECEPTORS
213 CHOLINOMIMETICS 214 CHOLINERGIC AGONISTS AND ANTAGONISTS 215
CLINICAL USE OF DIRECT-ACTING CHOLINOMIMETICS 215 ANTIMUSCARINIC 221
DRUG-INDUCED ENZYME INHIBITION 223 DRUG EFFECTS MEDIATED THROUGH ENZYME
INHIBITION 223 COMPETITIVE, UNCOMPETITIVE, AND NONCOMPETITIVE INHIBITION
225 COMPETITIVE INHIBITION 225 UNCOMPETITIVE INHIBITION 226
NONCOMPETITIVE INHIBITION 228 ALLOSTERIC REGULATION 228 COOPERATIVITY
229 FEEDBACK INHIBITION 229 EXAMPLES OF DRUG-ENZYME INTERACTIONS 230
ACETYLCHOLINESTERASE 230 BUTYRYLCHOLINESTERASE (BUCHE) 231 THE ACTIVE
CENTER OF CHOLINESTERASE 232 ANTICHOLINESTERASE DRUGS 234 CONTENTS * XV
TYPES OF CHOLINESTERASE INHIBITORS 234 REVERSIBLE ANTICHOLINESTERASES
234 IRREVERSIBLE ANTICHOLINESTERASES 235 EFFECTS OF ANTICHOLINESTERASE
DRUGS 236 USES OF ANTICHOLINESTERASE DRUGS 238 ANTIOCHOLINESTERASES FOR
THE TREATMENT OF GLAUCOMA 238 ANTICHOLINESTERASE FOR THE TREATMENT OF
MYASTHENIA GRAVIS 239 POISONOUS EFFECTS OF IRREVERSIBLE
ANTICHOLINESTERASES 241 CHOLINESTERASE-REGENERATING COMPOUNDS 241
TRANSPEPTIDASE-PENICILLINASE INHIBITION PRODUCING PHARMACOLOGICAL
EFFECTS 243 TRANSPEPTIDASE 243 BACTERIAL CELL WALL SYNTHESIS 243
PEPTIDOGLYCANS 245 TRANSPEPTIDASE 246 TRANSPEPTIDASE INHIBITORS 248
PENICILLINS 250 PENICILLINASES 251 BETA-LACTAMASE INHIBITORS 251 SUICIDE
INHIBITION OF ENZYMES 254 SUICIDE INHIBITION OF THYMIDYLATE SYNTHETASE
(TS) 254 SUICIDE INHIBITION OF XANTHINE OXIDASE (XO) 255 REFERENCES 258
10 DRUG-RECEPTOR DYNAMICS AND THEORIES 259 OCCUPATION THEORY (CLARK) 259
MODIFIED OCCUPANCY THEORY (ARIENS) 264 RATE THEORY (PATON) 264
RELATIONSHIP BETWEEN CONCENTRATION AND RESPONSE 269 CONCENTRATION-EFFECT
CURVES 269 DRUG ANTAGONISM 270 COMPETITIVE ANTAGONISM 271 SCHILD S
EQUATION 275 WHAT IS THE IMPORTANCE OF THIS MATHEMATICAL RELATIONSHIP?
278 IRREVERSIBLE ANTAGONISM 280 NONCOMPETITIVE ANTAGONISM 281 PARTIAL
AGONISTS 282 VARIOUS FACTORS THAT CAN REGULATE A DRUG S EFFECT 285
POTENCY AND EFFICACY 286 POTENCY 286 EFFICACY 287 DOSE-RESPONSE CURVES
288 GRADED DOSE-RESPONSE CURVES 288 QUANTAL DOSE-RESPONSE CURVES 290
STATISTICS THAT CAN BE DERIVED FROM THE QUANTAL DOSE-RESPONSE CURVE 291
THERAPEUTIC INDEX 293 XVI * BASIC PHARMACOLOGY: UNDERSTANDING DRUG
ACTIONS AND REACTIONS TIME-ACTION CURVES 296 PHASE I: TIME TO ONSET OF
ACTION 297 PHASE II: TIME TO PEAK EFFECT 297 PHASE III: DURATION OF
ACTION 297 PHASE IV: RESIDUAL EFFECTS 297 SAMPLE PROBLEMS 297 PRACTICE
PROBLEMS 303 ANSWERS FOR THE PROBLEMS 305 REFERENCES 306 11 RECEPTOR
REGULATION AND SIGNALING MECHANISMS 307 SPARE RECEPTORS 307 OVERSHOOT
308 DOWN REGULATION 309 OTHER FACTORS THAT CAN AFFECT DRUG RESPONSE 312
TOLERANCE 312 TACHYPHYLAXIS 312 IDIOSYNCRATIC DRUG RESPONSE 313 RECEPTOR
SIGNALING AND SECOND MESSENGER SYSTEMS 313 FOUR BASIC MECHANISMS OF
RECEPTOR SIGNALING 313 THE FOUR MAJOR TYPES OF SECOND MESSENGERS 315
HORMONES ACTING THROUGH INTRACELLULAR RECEPTORS 318 MECHANISM OF ACTION
318 LIGANDS ACTING THROUGH CELL SURFACE RECEPTORS 320 PROTEIN KINASES
320 PHOSPHORYLATION AND THE EFFECTS OF PHOSPHORYLATION 320 TWO TYPES OF
PROTEIN KINASES 320 EXAMPLES OF RECEPTOR SIGNALING BY ACTIVATION OF
TYROSINE KINASES 322 PHOSPHORYLATION-INDUCED RECEPTOR DOWN REGULATION
AND RECEPTOR DESENSITIZATION 323 RECEPTOR-COUPLED (MEMBRANE-BOUND)
GUANYLATE CYCLASE (GC) 325 SOLUBLE GUANYLATE CYCLASE 326 RECEPTORS
LINKED TO G-PROTEINS AND SECOND MESSENGER PRODUCTION 327 ACTIVATION OF
ADENYLATE CYCLASE AND G-PROTEIN FUNCTION 329 DOWNSTREAM CAMP SECOND
MESSENGER PATHWAY 331 CA 2 7PHOSPHOINOSITIDE/PKC SIGNALING PATHWAY 331
WHAT IS THE PURPOSE OF G-PROTEINS OR ANY OTHER SECOND MESSENGER SYSTEM?
334 LIGAND-GATED ION CHANNELS 334 SIGNALING THROUGH VOLTAGE-DEPENDENT
ION CHANNELS 336 VOLTAGE-DEPENDENT SODIUM (NA + ) CHANNEL 336
VOLTAGE-GATED POTASSIUM (K + ) CHANNEL 337 LIGAND-GATED SODIUM CHANNEL
337 CALCIUM CHANNELS 338 LOCATION(S) OF THE VOLTAGE-SENSITIVE CA 2+
CHANNELS (VSCC) 339 CONTENTS * XVII HOW DOES CALCIUM CONTRACT THE
SKELETAL MUSCLES AND THE VASCULAR SMOOTH MUSCLES? 342 CHLORIDE CHANNEL
344 GABA RECEPTORS 344 STRUCTURE OF GABA A RECEPTORS 344 GABA BINDING
SITE 346 BENZODIAZEPINE BINDING SITE 348 BARBITURATES BINDING SITE 348
PICROTOXIN BINDING SITE 349 GABA ANTAGONISTS 349 REFERENCES 350 INDEX
353
|
| adam_txt |
BASIC PHARMACOLOGY UNDERSTANDING DRUG ACTIONS AND REACTIONS MARIA A.
HERNANDEZ PH.D. PHARMACEUTICAL AND ADMINISTRATIVE COLLEGE OF PHARMACY
NOVA SOUTHEASTERN UNIVERSITY FT. LAUDERDALE, FLORIDA, U.S.A. APPU
RATHINAVELU PH.D. PHARMACEUTICAL AND ADMINISTRATIVE COLLEGE OF PHARMACY
NOVA SOUTHEASTERN UNIVERSITY FT. LAUDERDALE, FLORIDA, U.S.A. (FIFTY)
TAYLOR & FRANCIS \V^ J TAYLOR & FRANCIS CROUP BOCA RATON LONDON NEW YORK
A CRC TITLE, PART OF THE TAYLOR & FRANCIS IMPRINT, A MEMBER OF THE
TAYLOR & FRANCIS CROUP, THE ACADEMIC DIVISION OF T&F INFORMA PIC.
CONTENTS SECTION I PHYSICOCHEMICAL PROPERTIES OF DRUGS 1 FUNDAMENTAL
CHEMICAL PROPERTIES OF DRUGS 3 INTRODUCTION 3 THE PERIODIC TABLE AND
PROPERTIES OF DRUGS 3 THE PERIODIC TABLE AND CHEMICAL REACTIVITY 10
CHEMICAL BONDS 16 MAGNITUDE OF IONIC CHARGE 18 POLYATOMIC IONS 19
COVALENT BONDS 20 COORDINATE COVALENT BONDS 25 RESONANCE STRUCTURES *.
27 SHAPES OF DRUG MOLECULES 28 ELECTRONEGATIVITY 33 POLARITY OF CHEMICAL
BONDS 33 MOLECULAR POLARITY 34 FURTHER READING 35 2 ACID-BASE PROPERTIES
OF DRUGS 37 HYDROLYSIS OF SALTS , 38 CONJUGATE ACIDS AND CONJUGATE BASES
41 STRENGTH OF ACIDS AND BASES 43 RESONANCE AND INDUCTIVE EFFECTS 47
INDUCTIVE EFFECTS 47 RESONANCE EFFECTS 49 THE HENDERSON-HASSELBACH
EQUATION 53 FURTHER READING 60 3 STRUCTURAL DETERMINANTS OF DRUG ACTION
61 STRUCTURALLY NONSPECIFIC DRUGS 6L VOLATILE ANESTHETICS 61
STRUCTURALLY SPECIFIC DRUGS 63 ISOSTERISM AND ISOSTERES 68 STRUCTURAL
CHANGES IN DRUG MOLECULES 71 FURTHER READING 76 XI XII * BASIC
PHARMACOLOGY: UNDERSTANDING DRUG ACTIONS AND REACTIONS 4 CHEMICAL
APPROACHES TO THE TREATMENT OF CANCER 77 NORMAL VS. MALIGNANT CELLS 77
CELL CYCLE AND CHEMOTHERAPY 78 FROM CHEMICAL WARFARE TO CHEMOTHERAPY 79
ANTICANCER DRUGS 80 ALKYLATING AGENTS 81 ANTIMETABOLITES 84 DNA
INTERCALATORS 87 DNA CROSSLINKING AGENTS 89 FURTHER READING 90 SECTION
II PRINCIPLES OF BIOPHARMACEUTICS 5 ADMINISTRATION AND ABSORPTION OF
DRUGS 93 DRUG ADMINISTRATION 93 PROPERTIES OF THE DRUG 94 DRUG
SOLUBILITY 94 POLYMORPHISM 97 PARTICLE SIZE 98 PK 98 THERAPEUTIC
OBJECTIVE 100 ONSET OF ACTION 100 LONG-TERM ADMINISTRATION 100
RESTRICTION TO A LOCAL SITE 101 DRUG ABSORPTION 101 PHYSIOLOGICAL AND
PHYSICOCHEMICAL FACTORS IN DRUG ABSORPTION 103 DRUG TRANSPORT ACROSS
MEMBRANES 103 PASSIVE DIFFUSION 103 ACTIVE TRANSPORT 104 FACILITATED
TRANSPORT 104 ION PAIR TRANSPORT 105 ENDOCYTOSIS, PINOCYTOSIS,
PHAGOCYTOSIS, AND EXOCYTOSIS 105 PH OF BODY COMPARTMENTS 105 OTHER
FACTORS THAT AFFECT ABSORPTION 107 BLOOD FLOW TO THE ABSORPTION SITE 107
SURFACE AREA AVAILABLE FOR ABSORPTION 108 CONTACT TIME AT THE ABSORPTION
SURFACE 108 DRUG ABSORPTION, BIOAVAILABILITY, AND FIRST-PASS METABOLISM
108 FURTHER READING 110 6 DISTRIBUTION AND EXCRETION OF DRUGS ILL
FACTORS IN DRUG DISTRIBUTION ILL CAPILLARY PERMEABILITY 112 BLOOD
PERFUSION 114 PERFUSION AND PERMEABILITY 114 DRUG STRUCTURE AND
COMPARTMENT PH 116 PLASMA PROTEIN BINDING 116 INTRACELLULAR BINDING 117
CONTENTS * XIII PATTERNS OF DISTRIBUTION 117 DETERMINATION OF THE VOLUME
OF DISTRIBUTION 120 CLEARANCE AND ELIMINATION RATE 122 CLEARANCE AND THE
MAINTENANCE DOSE RATE 122 HALF-LIFE AND THE STEADY STATE 125
BIOAVAILABILITY 127 DRUG ELIMINATION 130 THE ENTEROHEPATIC CYCLE 130
RENAL EXCRETION 131 RENAL PROCESSES 132 FURTHER READING 133 7 METABOLIC
CHANGES OF DRUGS 135 CYTOCHROMES P450 136 INHIBITION OF DRUG METABOLISM
138 INDUCTION OF DRUG METABOLISM 138 ENVIRONMENTAL AND GENETIC FACTORS
IN METABOLISM BY CYP450 139 CLOZAPINE AND CYP1A2 ACTIVITY 142 GENETIC
POLYMORPHISM AND CYP2D6 142 CYP2D6 AND CODEINE 143 GENETIC POLYMORPHISM
AND CYP2C19 143 DRUG INTERACTIONS VIA THE CYP2C19 ISOFORM:
OMEPRAZOLE-DIAZEPAM INTERACTION 143 CYP3A FAMILY 143 CYP3A4 AND
GRAPEFRUIT JUICE 144 REDOX REACTIONS AND THE CYP450 ENZYME COMPLEX 144
NADVNADH SYSTEM 145 FAD/FADH SYSTEM 147 THE CYTOCHROME P45O CYCLE 147
PHASE I AND PHASE II REACTIONS OF DRUG METABOLISM 149 PHASE I REACTIONS
149 OXIDATIONS USING CYP450 ENZYMES 149 OXIDATION USING OTHER ENZYMES
163 REDUCTION 166 HYDROLYSIS REACTIONS 167 PHASE II REACTIONS
(CONJUGATION) 171 DOSE-DEPENDENT TOXICITY OF ACETAMINOPHEN 178 FURTHER
READING 186 SECTION III PRINCIPLES OF DRUG-RECEPTOR AND DRUG-ENZYME
INTERACTIONS 8 DRUG RECEPTORS AND PHARMACODYNAMICS 189 MECHANISMS OF
DRUG ACTION 189 CHEMICAL SIGNALING AND RECEPTOR FUNCTION 189 CHEMICAL
SIGNALING 189 AUTOCRINE, PARACRINE, AND ENDOCRINE FUNCTION 192 NATURE OF
THE SIGNALING MOLECULES (LIGANDS) 192 XIV * BASIC PHARMACOLOGY:
UNDERSTANDING DRUG ACTIONS AND REACTIONS DIFFERENT KINDS OF RECEPTORS
194 EXTRACELLULAR RECEPTORS 196 INTRACELLULAR RECEPTORS ; 196 PLASMA
MEMBRANE-BOUND RECEPTORS 196 THREE TYPES OF PLASMA MEMBRANE-BOUND
RECEPTORS 196 MODELS OF DRUG-RECEPTOR INTERACTION 198 DRUG-RECEPTOR
INTERACTIONS 198 KEY FEATURES OF BINDING SITES 198 LOCK-AND-KEY FIT 198
INDUCED FIT 199 AFFINITY AND INTRINSIC ACTIVITY 200 AFFINITY 200
INTRINSIC ACTIVITY 200 AGONISTS, ANTAGONISTS, AND PARTIAL AGONISTS 201
AGONISTS 201 ANTAGONISTS 201 PARTIAL AGONIST 201 LIGAND STRUCTURE AND
ACTIVITY RELATIONSHIP 201 WHY IS THE RECEPTOR CONCEPT IMPORTANT? 202
DIFFERENTIAL EFFECTS OF AGONISTS 202 DIFFERENTIAL EFFECTS OF EPINEPHRINE
202 SELECTIVE ACTIONS OF ADRENERGIC AGONISTS AND ANTAGONISTS 205
ATYPICAL RECEPTORS 208 CHOLINERGIC NEUROTRANSMISSION 209 SYNTHESIS AND
RELEASE OF ACETYLCHOLINE 210 DIFFERENTIAL EFFECTS OF ACETYLCHOLINE
THROUGH CHOLINERGIC RECEPTORS. 211 MUSCARINIC AND NICOTINIC ACTIONS OF
ACETYLCHOLINE 212 THE LOCATION AND FUNCTION OF ACETYLCHOLINE RECEPTORS
213 CHOLINOMIMETICS 214 CHOLINERGIC AGONISTS AND ANTAGONISTS 215
CLINICAL USE OF DIRECT-ACTING CHOLINOMIMETICS 215 ANTIMUSCARINIC 221
DRUG-INDUCED ENZYME INHIBITION 223 DRUG EFFECTS MEDIATED THROUGH ENZYME
INHIBITION 223 COMPETITIVE, UNCOMPETITIVE, AND NONCOMPETITIVE INHIBITION
225 COMPETITIVE INHIBITION 225 UNCOMPETITIVE INHIBITION 226
NONCOMPETITIVE INHIBITION 228 ALLOSTERIC REGULATION 228 COOPERATIVITY
229 FEEDBACK INHIBITION 229 EXAMPLES OF DRUG-ENZYME INTERACTIONS 230
ACETYLCHOLINESTERASE 230 BUTYRYLCHOLINESTERASE (BUCHE) 231 THE ACTIVE
CENTER OF CHOLINESTERASE 232 ANTICHOLINESTERASE DRUGS 234 CONTENTS * XV
TYPES OF CHOLINESTERASE INHIBITORS 234 REVERSIBLE ANTICHOLINESTERASES
234 IRREVERSIBLE ANTICHOLINESTERASES 235 EFFECTS OF ANTICHOLINESTERASE
DRUGS 236 USES OF ANTICHOLINESTERASE DRUGS 238 ANTIOCHOLINESTERASES FOR
THE TREATMENT OF GLAUCOMA 238 ANTICHOLINESTERASE FOR THE TREATMENT OF
MYASTHENIA GRAVIS 239 POISONOUS EFFECTS OF IRREVERSIBLE
ANTICHOLINESTERASES 241 CHOLINESTERASE-REGENERATING COMPOUNDS 241
TRANSPEPTIDASE-PENICILLINASE INHIBITION PRODUCING PHARMACOLOGICAL
EFFECTS 243 TRANSPEPTIDASE 243 BACTERIAL CELL WALL SYNTHESIS 243
PEPTIDOGLYCANS 245 TRANSPEPTIDASE 246 TRANSPEPTIDASE INHIBITORS 248
PENICILLINS 250 PENICILLINASES 251 BETA-LACTAMASE INHIBITORS 251 SUICIDE
INHIBITION OF ENZYMES 254 SUICIDE INHIBITION OF THYMIDYLATE SYNTHETASE
(TS) 254 SUICIDE INHIBITION OF XANTHINE OXIDASE (XO) 255 REFERENCES 258
10 DRUG-RECEPTOR DYNAMICS AND THEORIES 259 OCCUPATION THEORY (CLARK) 259
MODIFIED OCCUPANCY THEORY (ARIENS) 264 RATE THEORY (PATON) 264
RELATIONSHIP BETWEEN CONCENTRATION AND RESPONSE 269 CONCENTRATION-EFFECT
CURVES 269 DRUG ANTAGONISM 270 COMPETITIVE ANTAGONISM 271 SCHILD'S
EQUATION 275 WHAT IS THE IMPORTANCE OF THIS MATHEMATICAL RELATIONSHIP?
278 IRREVERSIBLE ANTAGONISM 280 NONCOMPETITIVE ANTAGONISM 281 PARTIAL
AGONISTS 282 VARIOUS FACTORS THAT CAN REGULATE A DRUG'S EFFECT 285
POTENCY AND EFFICACY 286 POTENCY 286 EFFICACY 287 DOSE-RESPONSE CURVES
288 GRADED DOSE-RESPONSE CURVES 288 QUANTAL DOSE-RESPONSE CURVES 290
STATISTICS THAT CAN BE DERIVED FROM THE QUANTAL DOSE-RESPONSE CURVE 291
THERAPEUTIC INDEX 293 XVI * BASIC PHARMACOLOGY: UNDERSTANDING DRUG
ACTIONS AND REACTIONS TIME-ACTION CURVES 296 PHASE I: TIME TO ONSET OF
ACTION 297 PHASE II: TIME TO PEAK EFFECT 297 PHASE III: DURATION OF
ACTION 297 PHASE IV: RESIDUAL EFFECTS 297 SAMPLE PROBLEMS 297 PRACTICE
PROBLEMS 303 ANSWERS FOR THE PROBLEMS 305 REFERENCES 306 11 RECEPTOR
REGULATION AND SIGNALING MECHANISMS 307 SPARE RECEPTORS 307 OVERSHOOT
308 DOWN REGULATION 309 OTHER FACTORS THAT CAN AFFECT DRUG RESPONSE 312
TOLERANCE 312 TACHYPHYLAXIS 312 IDIOSYNCRATIC DRUG RESPONSE 313 RECEPTOR
SIGNALING AND SECOND MESSENGER SYSTEMS 313 FOUR BASIC MECHANISMS OF
RECEPTOR SIGNALING 313 THE FOUR MAJOR TYPES OF SECOND MESSENGERS 315
HORMONES ACTING THROUGH INTRACELLULAR RECEPTORS 318 MECHANISM OF ACTION
318 LIGANDS ACTING THROUGH CELL SURFACE RECEPTORS 320 PROTEIN KINASES
320 PHOSPHORYLATION AND THE EFFECTS OF PHOSPHORYLATION 320 TWO TYPES OF
PROTEIN KINASES 320 EXAMPLES OF RECEPTOR SIGNALING BY ACTIVATION OF
TYROSINE KINASES 322 PHOSPHORYLATION-INDUCED RECEPTOR DOWN REGULATION
AND RECEPTOR DESENSITIZATION 323 RECEPTOR-COUPLED (MEMBRANE-BOUND)
GUANYLATE CYCLASE (GC) 325 SOLUBLE GUANYLATE CYCLASE 326 RECEPTORS
LINKED TO G-PROTEINS AND SECOND MESSENGER PRODUCTION 327 ACTIVATION OF
ADENYLATE CYCLASE AND G-PROTEIN FUNCTION 329 DOWNSTREAM CAMP SECOND
MESSENGER PATHWAY 331 CA 2 7PHOSPHOINOSITIDE/PKC SIGNALING PATHWAY 331
WHAT IS THE PURPOSE OF G-PROTEINS OR ANY OTHER SECOND MESSENGER SYSTEM?
334 LIGAND-GATED ION CHANNELS 334 SIGNALING THROUGH VOLTAGE-DEPENDENT
ION CHANNELS 336 VOLTAGE-DEPENDENT SODIUM (NA + ) CHANNEL 336
VOLTAGE-GATED POTASSIUM (K + ) CHANNEL 337 LIGAND-GATED SODIUM CHANNEL
337 CALCIUM CHANNELS 338 LOCATION(S) OF THE VOLTAGE-SENSITIVE CA 2+
CHANNELS (VSCC) 339 CONTENTS * XVII HOW DOES CALCIUM CONTRACT THE
SKELETAL MUSCLES AND THE VASCULAR SMOOTH MUSCLES? 342 CHLORIDE CHANNEL
344 GABA RECEPTORS 344 STRUCTURE OF GABA A RECEPTORS 344 GABA BINDING
SITE 346 BENZODIAZEPINE BINDING SITE 348 BARBITURATES BINDING SITE 348
PICROTOXIN BINDING SITE 349 GABA ANTAGONISTS 349 REFERENCES 350 INDEX
353 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Hernandez, Maria A. Rathinavelu, Appu |
| author_GND | (DE-588)1053951671 |
| author_facet | Hernandez, Maria A. Rathinavelu, Appu |
| author_role | aut aut |
| author_sort | Hernandez, Maria A. |
| author_variant | m a h ma mah a r ar |
| building | Verbundindex |
| bvnumber | BV021552202 |
| callnumber-first | R - Medicine |
| callnumber-label | RM300 |
| callnumber-raw | RM300 |
| callnumber-search | RM300 |
| callnumber-sort | RM 3300 |
| callnumber-subject | RM - Therapeutics and Pharmacology |
| classification_rvk | VT 5010 |
| ctrlnum | (OCoLC)300272236 (DE-599)BVBBV021552202 |
| discipline | Chemie / Pharmazie |
| discipline_str_mv | Chemie / Pharmazie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02348nam a2200385 c 4500</leader><controlfield tag="001">BV021552202</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20140721 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">060418s2006 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1587161605</subfield><subfield code="9">1-58716-160-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781587161605</subfield><subfield code="9">978-1-58716-160-5</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)300272236</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV021552202</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-19</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM300</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VT 5010</subfield><subfield code="0">(DE-625)147739:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hernandez, Maria A.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Basic pharmacology</subfield><subfield code="b">understanding drug actions and reactions</subfield><subfield code="c">Maria A. Hernandez ; Appu Rathinavelu</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boca Raton [u.a.]</subfield><subfield code="b">CRC press</subfield><subfield code="c">2006</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XVII, 369 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">CRC press pharmacy education series</subfield></datafield><datafield tag="520" ind1="3" ind2=" "><subfield code="a">Written as an introductory pharmacology text, Basic Pharmacology: Understanding Drug Actions and Reactions provides the in-depth discussion of the chemical and molecular pharmacology fundamentals that pharmacy students require to move on to more advanced study. The book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. It emphasizes the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and interactions. The book effectively explains chemical and molecular pharmacology principles with extensive use of model drug molecules. (Midwest).</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Absorption - Acide - Action - Administration - Base - Biopharmaceutique - Cancer - Chimique - Distribution - Enzyme</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Excretion - Gaba - Inhibition - Interaction - Mecanisme - Medicament - Medication - Metabolisme - Pharmacodynamique - Pharmacologie</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Propriete - Reaction - Recepteur - Regulation - Signal - Traitement</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmacologie</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rathinavelu, Appu</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1053951671</subfield><subfield code="4">aut</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">GBV Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014768257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-014768257</subfield></datafield></record></collection> |
| id | DE-604.BV021552202 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:32:05Z |
| indexdate | 2024-07-09T20:38:27Z |
| institution | BVB |
| isbn | 1587161605 9781587161605 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014768257 |
| oclc_num | 300272236 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XVII, 369 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | CRC press |
| record_format | marc |
| series2 | CRC press pharmacy education series |
| spelling | Hernandez, Maria A. Verfasser aut Basic pharmacology understanding drug actions and reactions Maria A. Hernandez ; Appu Rathinavelu Boca Raton [u.a.] CRC press 2006 XVII, 369 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier CRC press pharmacy education series Written as an introductory pharmacology text, Basic Pharmacology: Understanding Drug Actions and Reactions provides the in-depth discussion of the chemical and molecular pharmacology fundamentals that pharmacy students require to move on to more advanced study. The book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. It emphasizes the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and interactions. The book effectively explains chemical and molecular pharmacology principles with extensive use of model drug molecules. (Midwest). Absorption - Acide - Action - Administration - Base - Biopharmaceutique - Cancer - Chimique - Distribution - Enzyme Excretion - Gaba - Inhibition - Interaction - Mecanisme - Medicament - Medication - Metabolisme - Pharmacodynamique - Pharmacologie Propriete - Reaction - Recepteur - Regulation - Signal - Traitement Pharmacologie Rathinavelu, Appu Verfasser (DE-588)1053951671 aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014768257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hernandez, Maria A. Rathinavelu, Appu Basic pharmacology understanding drug actions and reactions Absorption - Acide - Action - Administration - Base - Biopharmaceutique - Cancer - Chimique - Distribution - Enzyme Excretion - Gaba - Inhibition - Interaction - Mecanisme - Medicament - Medication - Metabolisme - Pharmacodynamique - Pharmacologie Propriete - Reaction - Recepteur - Regulation - Signal - Traitement Pharmacologie |
| title | Basic pharmacology understanding drug actions and reactions |
| title_auth | Basic pharmacology understanding drug actions and reactions |
| title_exact_search | Basic pharmacology understanding drug actions and reactions |
| title_exact_search_txtP | Basic pharmacology understanding drug actions and reactions |
| title_full | Basic pharmacology understanding drug actions and reactions Maria A. Hernandez ; Appu Rathinavelu |
| title_fullStr | Basic pharmacology understanding drug actions and reactions Maria A. Hernandez ; Appu Rathinavelu |
| title_full_unstemmed | Basic pharmacology understanding drug actions and reactions Maria A. Hernandez ; Appu Rathinavelu |
| title_short | Basic pharmacology |
| title_sort | basic pharmacology understanding drug actions and reactions |
| title_sub | understanding drug actions and reactions |
| topic | Absorption - Acide - Action - Administration - Base - Biopharmaceutique - Cancer - Chimique - Distribution - Enzyme Excretion - Gaba - Inhibition - Interaction - Mecanisme - Medicament - Medication - Metabolisme - Pharmacodynamique - Pharmacologie Propriete - Reaction - Recepteur - Regulation - Signal - Traitement Pharmacologie |
| topic_facet | Absorption - Acide - Action - Administration - Base - Biopharmaceutique - Cancer - Chimique - Distribution - Enzyme Excretion - Gaba - Inhibition - Interaction - Mecanisme - Medicament - Medication - Metabolisme - Pharmacodynamique - Pharmacologie Propriete - Reaction - Recepteur - Regulation - Signal - Traitement Pharmacologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014768257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hernandezmariaa basicpharmacologyunderstandingdrugactionsandreactions AT rathinaveluappu basicpharmacologyunderstandingdrugactionsandreactions |