Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2011
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-230249 Inhaltsverzeichnis |
| Beschreibung: | XIII, 123 Bl. Ill., graph. Darst. |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV040691786 | ||
| 003 | DE-604 | ||
| 005 | 20130207 | ||
| 007 | t | ||
| 008 | 130122s2011 ad|| m||| 00||| eng d | ||
| 035 | |a (OCoLC)826603058 | ||
| 035 | |a (DE-599)BVBBV040691786 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-384 |a DE-473 |a DE-703 |a DE-1051 |a DE-824 |a DE-29 |a DE-12 |a DE-91 |a DE-19 |a DE-1049 |a DE-92 |a DE-739 |a DE-898 |a DE-355 |a DE-706 |a DE-20 |a DE-1102 | ||
| 084 | |a XD 5604 |0 (DE-625)152576:12910 |2 rvk | ||
| 100 | 1 | |a Heigl, Ulrike |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication |c vorgelegt von Ulrike Heigl |
| 264 | 1 | |c 2011 | |
| 300 | |a XIII, 123 Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Regensburg, Univ., Diss., 2011 | ||
| 650 | 0 | 7 | |a Listeria monocytogenes |0 (DE-588)4203141-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Rezeptor |0 (DE-588)4049722-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Phagosom |0 (DE-588)4344159-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Tumor-Nekrose-Faktor |g alpha |0 (DE-588)4323543-8 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Phagosom |0 (DE-588)4344159-2 |D s |
| 689 | 0 | 1 | |a Listeria monocytogenes |0 (DE-588)4203141-2 |D s |
| 689 | 0 | 2 | |a Tumor-Nekrose-Faktor |g alpha |0 (DE-588)4323543-8 |D s |
| 689 | 0 | 3 | |a Rezeptor |0 (DE-588)4049722-7 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:355-epub-230249 |
| 856 | 4 | 1 | |u http://epub.uni-regensburg.de/23024/ |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | |u https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-230249 |x Resolving-System | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025672512&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-025672512 | ||
Datensatz im Suchindex
| _version_ | 1804149990129401856 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
CONTENTS
SYMBOLS IV
SUMMARY IX
ZUSAMMENFASSUNG IN DEUTSCHER SPRACHE X I
1. INTRODUCTION 1
1.1. THE PATHOGEN LISTERIA MONOCYTOGENES 1
1.2. THE LIFE CYCLE O F LISTERIA MONOCYTOGENES IN HOST CELLS 1
1.2.1. THE CYTOLYSIN LISTERIOLYSIN 0 3
1.3. IMMUNE RESPONSE TO LISTERIA MONOCYTOGENES - COMPONENTS AND
MECHANISMS 3
1.3.1. INNATE IMMUNE RESPONSE 4
1.3.2. ADAPTIVE IMMUNE RESPONSE 5
1.3.3. MACROPHAGES 7
1.3.4. PHAGOCYTOSIS AND PHAGOSOME MATURATION 9
1.3.5. CATHEPSIN D 12
1.4. STRUCTURAL AND FUNCTIONAL FEATURES O F TNFRS AND LIGANDS 13
1.4.1. TNFR SUPERFAMILY 13
1.4.2. TUMOR NECROSIS FACTOR A 14
1.4.3. TUMOR NECROSIS FACTOR RECEPTOR-1 15
1.5. THE DIVERSITY O F TNF-R1 SIGNALLING 16
1.5.1. APOPTOTIC SIGNALLING VIA DISC FORMATION 16
1.5.2. APOPTOTIC SIGNALLING VIA ACID AND NEUTRAL SPHINGOMYELINASE
ACTIVATION 18
1 . 5 . 3 . ANTI-APOPTOTIC SIGNALLING VIA N F - K B 2 0
1.5.4. THE MAP-KINASE SIGNALLING 22
1.6. THE SIGNALLING PATHWAY O F INTERFERONS 23
1.7. OBJECTIVES O F THIS WORK 26
2. MATERIAL & METHODS 2 8
2.1. MATERIALS 28
2.1.1. DEVICES 28
2.1.2. CONSUMABLES 28
2.1.3. CHEMICALS AND REAGENTS 29
2.1.4. KITS 3 1
2.1.5. BUFFERS AND SOLUTIONS 3 1
2.1.6. CELL CULTURE AND BACTERIA MEDIA 32
2.1.7. MOUSE STRAINS 32
2.1.8. CELL LINES 32
2.1.9. BACTERIAL STRAINS 33
2.1.10. SOFTWARE 33
2.2. CELL BIOLOGICAL METHODS 33
2.2.1. CELL CULTURE AND CONDITIONS . R. 33
- I -
HTTP://D-NB.INFO/103193930X
IMAGE 2
CONTENTS
2.2.2. GENERATION O F BONE MARROW DERIVED MACROPHAGES 33
2.2.3. STIMULATION O F CELLS 34
2.2.4. GENERATION O F M-CSF CONTAINING SUPERNATANT (L929-CM) 34
2.2.5. DETERMINATION O F CELL NUMBERS 35
2.2.6. BACTERIAL GROWTH ASSAYS 35
2.2.7. DETERMINATION O F BACTERIAL UPTAKE 35
2.2.8. FLOW CYTOMETRY 36
2.2.9. CONFOCAL MICROSCOPY AND IMMUNOFLUORESCENCE STAINING 36
2.2.10. TRANSMISSION ELECTRON MICROSCOPY O F INFECTED CELLS AND
MAGNETICALLY ISOLATED PHAGOSOMES 37
2.2.11. TRANSMISSION ELECTRON MICROSCOPY O F TNF-R1 TRAFFICKING AND
COLOCALISATION WITH PHAGOSOMES 38
2.2.12. FLUORESCENCE LABELLING O F TNF-R1 AND COLOCALISATION WITH
LISTERIA MONOCYTOGENES... 38
2.2.13. MAGNETIC LABELLING O F TNF-RECEPTOR AND ISOLATION O F TNF
RECEPTOSOMES IN LISTERIA MONOCYTOGENES- INFECTED MACROPHAGES 39
2.2.14. ISOLATION O F LISTERIA MONOCYTOGENES- CONTAINING PHAGOSOMES 40
2.2.15. CELLLYSATES 40
2.3. WORKING WITH BACTERIA 4 1
2.3.1. CULTIVATION O F BACTERIA AND INFECTION O F MACROPHAGES 4 1
2.3.2. MAGNETIC AND FLUORESCENT LABELLING O F BACTERIA 4 1
2.3.3. GENERATION O F GFP-EXPRESSING LISTERIA MONOCYTOGENES 4 1
2.4. WORKING WITH PROTEINS 42
2.4.1. MEASURING O F PROTEIN CONCENTRATIONS 42
2.4.2. SDS-PAGE 42
2.4.3. WESTERN BLOT ANALYSIS AND IMMUNOLOGICAL DETECTION O F PROTEINS 43
2.4.4. ELISA FOR DETECTION O F TNFA 44
2.4.5. DETECTION O F NO - GRIESS REAGENT 45
3. RESULTS 4 6
3.1. BACTERIAL PROPAGATION IN J774 MACROPHAGES - THE ROLE O F IFNY AND
TNFA FOR INFECTION CONTROL 46
3.2. TUMOR NECROSIS FACTOR RECEPTOR 1 - LOCALISATION IN INFECTED J774
MACROPHAGES 50
3.3. ANALYSIS O F LISTERIA MONOCYTOGENES- CONTAINING PHAGOSOMES - A NEW
METHOD O F PHAGOSOME ISOLATION 53
3.3.1. INCORPORATION O F LIPOBIOTIN INTO LISTERIA MONOCYTOGENES MEMBRANE
56
3.3.2. INFLUENCE O F LIPOBIOTIN ON LISTERIA MONOCYTOGENES LIFE CYCLE 56
3.3.3. INFLUENCE O F LABELLED BACTERIA ON MACROPHAGES 58
3.3.4. MAGNETIC LABELLING O F LISTERIA MONOCYTOGENES 60
3.3.5. PROTEIN DISTRIBUTION AFTER PHAGOSOME SEPARATION 63
-II-
IMAGE 3
CONTENTS
3.4. PHAGOCYTOSIS O F LISTERIA MONOCYTOGENES BY J774 MACROPHAGES - THE
INFLUENCE O F CYTOKINES TO PROTEIN COMPOSITION O F PHAGOSOMES 66
3.5. TUMOR NECROSIS FACTOR RECEPTOR 1 - A NEW COMPONENT O F THE LISTERIA
MONOCYTOGENES CONTAINING PHAGOSOME 69
3.6. CONTRIBUTION O F TNF-R1 SIGNALLING TO PRIMARY MACROPHAGES 70
3.6.1. BACTERIAL PROPAGATION IN WILD-TYPE MACROPHAGES - THE ROLE O F
TNFA AND IFNY FOR INFECTION CONTROL 7 1
3.6.2. THE INFLUENCE O F CYTOKINES T O THE PROTEIN COMPOSITION O F
PHAGOSOMES FROM WILD-TYPE MACROPHAGES 74
3.6.3. BACTERIAL INFECTION CONTROL IN TNF-RL 7 MACROPHAGES 76
3.6.4. THE INFLUENCE O F CYTOKINES T O PROTEIN COMPOSITION O F
PHAGOSOMES FROM TNF-R1 MACROPHAGES 79
3.6.5. BACTERIAL INFECTION CONTROL IN IFNYRMACROPHAGES 80
3.6.6. PROTEIN COMPOSITION O F PHAGOSOMES FROM IFNYR 7 MACROPHAGES 83
3.6.7. INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) AS EFFECTOR MOLECULE FOR
ERADICATION 85
4. DISCUSSION 8 8
4.1. ERADICATION O F INTRACELLULAR BACTERIA WITH THE INFECTION MODEL O F
LISTERIA MONOCYTOGENES IN MACROPHAGES 89
4.1.1. THE SYNERGY O F IFNY AND TNFA IS REQUIRED FOR INFECTION CONTROL O
F LISTERIA MONOCYTOGENES IN MACROPHAGES 89
4.2. BIOLOGICAL FUNCTION O F TNF-R1 INTERNALISATION IN MACROPHAGES 9 1
4.2.1. TNF-R1 IS A COMPONENT O F LISTERIA MONOCYTOGENES- CONTAINING
PHAGOSOMES 92
4.2.2. ACTIVATION O F CTSD IN THE PHAGOSOME - RECEPTOSOME COMPARTMENT IN
J774 MACROPHAGES IS INDUCED BY TNF-R1 93
4.2.3. ACTIVATION O F CTSD IN THE PHAGOSOME - RECEPTOSOME COMPARTMENT IN
PRIMARY MACROPHAGES IS INDEPENDENT O F TNF-R1 95
4.2.4. THE ROLE O F THE IFNY INDUCED PROTEINS RAB5A AND LRG-47 ON THE
PHAGOSOME 97
4.3. OXIDATIVE BURST FORMATION AND RNI GENERATION IN CONTEXT WITH TNF-R1
SIGNALLING 99
4.4. MAGNETIC ISOLATION O F LISTERIA MONOCYTOGENES- CONTAINING
PHAGOSOMES 100
4.5. CONCLUSION AND PERSPECTIVE 102
5. REFERENCES 104
6. LIST OF FIGURES AND TABLES 114
7. APPENDIX 115
7.1. TEM O F MAGNETIC LABELLED LISTERIA MONOCYTOGENES IN J774
MACROPHAGES 115
7.2. TEM O F ISOLATED PHAGOSOMES 119
ACKNOWLEDGEMENTS 122
|
| any_adam_object | 1 |
| author | Heigl, Ulrike |
| author_facet | Heigl, Ulrike |
| author_role | aut |
| author_sort | Heigl, Ulrike |
| author_variant | u h uh |
| building | Verbundindex |
| bvnumber | BV040691786 |
| classification_rvk | XD 5604 |
| collection | ebook |
| ctrlnum | (OCoLC)826603058 (DE-599)BVBBV040691786 |
| discipline | Medizin |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02090nam a2200445 c 4500</leader><controlfield tag="001">BV040691786</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20130207 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">130122s2011 ad|| m||| 00||| eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)826603058</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV040691786</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-384</subfield><subfield code="a">DE-473</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-1051</subfield><subfield code="a">DE-824</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-91</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-1049</subfield><subfield code="a">DE-92</subfield><subfield code="a">DE-739</subfield><subfield code="a">DE-898</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-706</subfield><subfield code="a">DE-20</subfield><subfield code="a">DE-1102</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XD 5604</subfield><subfield code="0">(DE-625)152576:12910</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Heigl, Ulrike</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication</subfield><subfield code="c">vorgelegt von Ulrike Heigl</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2011</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIII, 123 Bl.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Regensburg, Univ., Diss., 2011</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Listeria monocytogenes</subfield><subfield code="0">(DE-588)4203141-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Rezeptor</subfield><subfield code="0">(DE-588)4049722-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Phagosom</subfield><subfield code="0">(DE-588)4344159-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Tumor-Nekrose-Faktor</subfield><subfield code="g">alpha</subfield><subfield code="0">(DE-588)4323543-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Phagosom</subfield><subfield code="0">(DE-588)4344159-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Listeria monocytogenes</subfield><subfield code="0">(DE-588)4203141-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Tumor-Nekrose-Faktor</subfield><subfield code="g">alpha</subfield><subfield code="0">(DE-588)4323543-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="3"><subfield code="a">Rezeptor</subfield><subfield code="0">(DE-588)4049722-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="C">b</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe</subfield><subfield code="o">urn:nbn:de:bvb:355-epub-230249</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://epub.uni-regensburg.de/23024/</subfield><subfield code="x">Verlag</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-230249</subfield><subfield code="x">Resolving-System</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025672512&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ebook</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-025672512</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV040691786 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:31:48Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025672512 |
| oclc_num | 826603058 |
| open_access_boolean | 1 |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 |
| physical | XIII, 123 Bl. Ill., graph. Darst. |
| psigel | ebook |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| record_format | marc |
| spelling | Heigl, Ulrike Verfasser aut Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication vorgelegt von Ulrike Heigl 2011 XIII, 123 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Regensburg, Univ., Diss., 2011 Listeria monocytogenes (DE-588)4203141-2 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Phagosom (DE-588)4344159-2 gnd rswk-swf Tumor-Nekrose-Faktor alpha (DE-588)4323543-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Phagosom (DE-588)4344159-2 s Listeria monocytogenes (DE-588)4203141-2 s Tumor-Nekrose-Faktor alpha (DE-588)4323543-8 s Rezeptor (DE-588)4049722-7 s b DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:355-epub-230249 http://epub.uni-regensburg.de/23024/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-230249 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025672512&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Heigl, Ulrike Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication Listeria monocytogenes (DE-588)4203141-2 gnd Rezeptor (DE-588)4049722-7 gnd Phagosom (DE-588)4344159-2 gnd Tumor-Nekrose-Faktor alpha (DE-588)4323543-8 gnd |
| subject_GND | (DE-588)4203141-2 (DE-588)4049722-7 (DE-588)4344159-2 (DE-588)4323543-8 (DE-588)4113937-9 |
| title | Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication |
| title_auth | Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication |
| title_exact_search | Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication |
| title_full | Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication vorgelegt von Ulrike Heigl |
| title_fullStr | Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication vorgelegt von Ulrike Heigl |
| title_full_unstemmed | Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication vorgelegt von Ulrike Heigl |
| title_short | Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes and its role for bacterial eradication |
| title_sort | impact of tumor necrosis factor receptor 1 signalling to listeria monocytogenes containing phagosomes and its role for bacterial eradication |
| topic | Listeria monocytogenes (DE-588)4203141-2 gnd Rezeptor (DE-588)4049722-7 gnd Phagosom (DE-588)4344159-2 gnd Tumor-Nekrose-Faktor alpha (DE-588)4323543-8 gnd |
| topic_facet | Listeria monocytogenes Rezeptor Phagosom Tumor-Nekrose-Faktor alpha Hochschulschrift |
| url | http://epub.uni-regensburg.de/23024/ https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-230249 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025672512&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT heiglulrike impactoftumornecrosisfactorreceptor1signallingtolisteriamonocytogenescontainingphagosomesanditsroleforbacterialeradication |