The molecular and ionic signaling of neutrophils:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1997
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 212 S. Ill., graph. Darst. |
| ISBN: | 3540631267 1570594635 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804126083413442560 |
|---|---|
| adam_text | i CONTENTS =n
1. The Neutrophil 1
Introduction 1
Decision Making in Neutrophils 1
Importance of Neutrophils 3
A Brief History of the Neutrophil 4
The Role of the Neutrophil in Inflammatory Disease 9
Basic Statistics of Neutrophils 10
Conclusion 12
2. Signaling in the Neutrophil: General Considerations 15
Introduction 15
Repertoire of Neutrophil Behavior 15
Diversity of Signaling Mechanism in Neutrophils 18
Local and Global Responses in Neutrophils 21
Local and Global Signaling 22
Importance of Neutrophil Shape for Localized Signaling 25
Integration of Neutrophil Activity 28
Ionic Environment of the Neutrophil Cytosol 31
Effect of Molecular Randomness on Neutrophil Signaling .... 31
Conclusion 34
3. Cytosolic Free Ca2+ Homeostasis in the Neutrophil 39
Introduction 39
Ca2+ Distribution in the Neutrophil 39
Resting Ca2+ Permeability 42
Plasma Membrane Ca2+ Pumps 43
Ca2+ Buffering Capacity in Neutrophils 45
Ca2+ Stores in Neutrophils 48
Conclusion 50
4. Cytosolic Free Ca2+ Signaling in Neutrophils 55
Introduction 55
Cytosolic Free Ca2+ Signaling by Seven
Transmembrane Spanning Domain Receptors 56
Signaling Delay with f Met Leu Phe 58
Cytosolic Free Ca2+ Signaling by Crosslinking Stimuli 61
Signaling Delay With Crosslinking 64
Capacitative Ca2t Influx 66
Ca2+ Channels 67
Surface Area/Volume Ratio and Ca2+ Influx Signaling 69
The Importance of Neutrophil Shape for Localized
Ca2+ Signaling 70
Cytosolic Free Ca2+ Diffusion in the Neutrophil Cytosol 70
Is the Neutrophil Nucleus a Barrier to Ca2+ Diffusion? 72
Do Ca2+ Waves Exist in Neutrophils? 74
Conclusion 75
5. Measuring and Imaging Cytosolic Free
Ca2+ in Neutrophils 83
Introduction 83
Chlortetracycline 83
Photoproteins 84
Fluorescent Ca2+ Chelator Indicators 84
Ca2+ Dissociation Constant of the Fluorescent Probe 85
Fluorescence Changes on Binding Ca2+ 87
Excitation and Emission Wavelengths 87
Ester Probe Loading 88
Ratiometric Fluorescence 89
Ca2+ Measurements in Neutrophil Populations 89
Ca2+ Measured in Individual Neutrophils 90
Quantitation of Cytosolic Free Ca2+ by Fluorescence 91
Imaging Cytosolic Free Ca2+ in Neutrophils 93
Problems With Fluorescent Imaging 95
Subcellular Ca2+ Heterogeneity 100
Conclusions 100
6. Phospholipid Signaling of Ca2+ in Neutrophils 105
Introduction 105
Phospholipases 105
IP3 Generation and Phospholipase C Activation 107
Phopholipase C p and Phopholipase C y 108
IP3 Production and Ca2+ Signaling 108
Phopholipase D 109
Phosphatidic Acid 109
Diglyceride Production 110
PI 3 Kinase 111
Sphingosine Metabolism 112
Conclusion 113
7. Other Intracellular Events: Na+, K+, pH
and Cyclic Nucleotides 119
Introduction 119
Na+ and K+ 119
Membrane Potential 119
Intracellular pH 120
Cyclic Nucleotides 120
Conclusion 121
8. Tyrosine Phosphorylation Signaling in Neutrophils 125
Introduction 125
Protein Tyrosine Kinases 125
MAP Kinase 126
MAP Kinases Kinase 126
The Ras Directed MAP Kinase/ERK 2 Pathway 129
Tyrosine Phosphatases 131
Conclusion 131
9. Signaling Neutrophil Adhesion, Shape Change
and Chemotaxis 135
Introduction 135
Adhesion to Endothelium 135
The (32 Integrins 136
The Role of Cytosolic Free Ca2+ 138
The Role of the Cytoskeleton 140
The Role of Tyrosine Phosphorylation 140
Cell Morphology Changes 141
Chemotaxis 142
Chemoattractants 142
The Driving Machinery of Neutrophils 143
Anchorage Molecules 144
Gradient Sensing 146
The Role of Cytosolic Free Ca2+ in Chemotaxis 147
Control of Actin Polymerization by Cytosolic Free Ca2+ 149
Interaction Between Actin and Signaling 150
Role of Tyrosine Phosphorylation in Chemotaxis 151
Role of Neutrophil Volume Changes 151
Conclusion 52
10. Signaling Neutrophil Priming 161
Introduction 61
Neutrophil Priming Agents 161
Mechanisms of Neutrophil Priming 162
Cross Talk Model of Priming 164
Conclusion 170
11. Signaling of Phagocytosis, Oxidase Activation
and Degranulation 179
Introduction 179
Phagocytosis 180
Cytosolic Free Ca2+ Signaling of Phagocytosis 182
Degranulation 183
Oxidase Activation 184
Signaling the Oxidase 188
Localization of Oxidase Activation 191
Conclusion 192
12. Signaling Neutrophil Death: Apoptosis and Necrosis 199
Introduction 199
Apoptosis 199
Necrosis 200
CD59 Protection 201
Conclusion 201
13. General Conclusions 203
Introduction 203
Physiology or Philosophy 203
Program of Neutrophil Behavior 204
Reliability of Neutrophils 205
Challenge for the Future 208
Index 209
|
| any_adam_object | 1 |
| author | Hallett, Maurice B. 1952- Lloyds, Darren 1968- |
| author_GND | (DE-588)115704108 (DE-588)115704116 |
| author_facet | Hallett, Maurice B. 1952- Lloyds, Darren 1968- |
| author_role | aut aut |
| author_sort | Hallett, Maurice B. 1952- |
| author_variant | m b h mb mbh d l dl |
| building | Verbundindex |
| bvnumber | BV011557824 |
| classification_rvk | WE 5300 |
| ctrlnum | (OCoLC)214945919 (DE-599)BVBBV011557824 |
| discipline | Biologie |
| format | Book |
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011557824 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:11:49Z |
| institution | BVB |
| isbn | 3540631267 1570594635 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007782317 |
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| owner_facet | DE-355 DE-BY-UBR DE-29 DE-12 DE-83 |
| physical | 212 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Hallett, Maurice B. 1952- Verfasser (DE-588)115704108 aut The molecular and ionic signaling of neutrophils Maurice B. Hallett ; Darren Lloyds New York [u.a.] Springer [u.a.] 1997 212 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Neutrophiler Granulozyt (DE-588)4171673-5 gnd rswk-swf Leukozyt (DE-588)4074195-3 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Calcium (DE-588)4069806-3 gnd rswk-swf Zellkommunikation (DE-588)4136131-3 gnd rswk-swf Leukotaxis (DE-588)4327799-8 gnd rswk-swf Lymphozytentransformation (DE-588)4168382-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Leukozyt (DE-588)4074195-3 s Lymphozytentransformation (DE-588)4168382-1 s DE-604 Signaltransduktion (DE-588)4318717-1 s Neutrophiler Granulozyt (DE-588)4171673-5 s Calcium (DE-588)4069806-3 s Zellkommunikation (DE-588)4136131-3 s Leukotaxis (DE-588)4327799-8 s Lloyds, Darren 1968- Verfasser (DE-588)115704116 aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007782317&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hallett, Maurice B. 1952- Lloyds, Darren 1968- The molecular and ionic signaling of neutrophils Neutrophiler Granulozyt (DE-588)4171673-5 gnd Leukozyt (DE-588)4074195-3 gnd Signaltransduktion (DE-588)4318717-1 gnd Calcium (DE-588)4069806-3 gnd Zellkommunikation (DE-588)4136131-3 gnd Leukotaxis (DE-588)4327799-8 gnd Lymphozytentransformation (DE-588)4168382-1 gnd |
| subject_GND | (DE-588)4171673-5 (DE-588)4074195-3 (DE-588)4318717-1 (DE-588)4069806-3 (DE-588)4136131-3 (DE-588)4327799-8 (DE-588)4168382-1 (DE-588)4143413-4 |
| title | The molecular and ionic signaling of neutrophils |
| title_auth | The molecular and ionic signaling of neutrophils |
| title_exact_search | The molecular and ionic signaling of neutrophils |
| title_full | The molecular and ionic signaling of neutrophils Maurice B. Hallett ; Darren Lloyds |
| title_fullStr | The molecular and ionic signaling of neutrophils Maurice B. Hallett ; Darren Lloyds |
| title_full_unstemmed | The molecular and ionic signaling of neutrophils Maurice B. Hallett ; Darren Lloyds |
| title_short | The molecular and ionic signaling of neutrophils |
| title_sort | the molecular and ionic signaling of neutrophils |
| topic | Neutrophiler Granulozyt (DE-588)4171673-5 gnd Leukozyt (DE-588)4074195-3 gnd Signaltransduktion (DE-588)4318717-1 gnd Calcium (DE-588)4069806-3 gnd Zellkommunikation (DE-588)4136131-3 gnd Leukotaxis (DE-588)4327799-8 gnd Lymphozytentransformation (DE-588)4168382-1 gnd |
| topic_facet | Neutrophiler Granulozyt Leukozyt Signaltransduktion Calcium Zellkommunikation Leukotaxis Lymphozytentransformation Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007782317&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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