Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VII, 136 Bl. Ill., graph. Darst. |
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| 245 | 1 | 0 | |a Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants |c by Constanze Hahn |
| 264 | 1 | |c 2011 | |
| 300 | |a VII, 136 Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 502 | |a Bochum, Univ., Diss., 2011 | ||
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Record in the Search Index
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| adam_text | Contents
List of
Figures
.......................................................................
IV
List of Tables
.........................................................................
V
List of Abbreviations
...........................................................
VI
Abstract
...................................................................................1
Chapter
1................................................................................3
Introduction
........................................................................................................................................3
1.1
General Introduction
.....................................................................................................................4
1.1.1
Functional brain lateralization of language processing
.........................................................4
1.1.2
The dichotic listening paradigm
.............................................................................................4
1.1.3
Sex differences
.......................................................................................................................6
1.1.4
The important role of nicotine
...............................................................................................7
1.1.5
Schizophrenia
-
a neurocognitive
disorder
............................................................................8
1.1.6
The dopamine hypothesis
......................................................................................................9
1.1.7
The self-medication hypothesis
...........................................................................................10
1.1.8
Attention Network Task
.......................................................................................................11
1.1.9
Study aims of this thesis
.......................................................................................................11
1.2
The neural mechanisms of dichotic listening
..............................................................................13
1.3
Sex-specific effects of smoking in dichotic listening
...................................................................16
1.4
Language lateralization in smoking and non-smoking schizophrenia patients
...........................19
1.5
Smoking effects on attention networks in schizophrenia
...........................................................21
Chapter
2..............................................................................23
Methods
............................................................................................................................................23
2.1
The neural mechanisms of dichotic listening
..............................................................................24
2.1.1
Subjects
................................................................................................................................24
2.1.2
Handedness and laterality index
..........................................................................................24
2.1.3
Procedure
.............................................................................................................................25
2.1.4
EEG
recordings
.....................................................................................................................26
2.1.5
Statistical analysis
.................................................................................................................27
2.2
Sex-specific effects of smoking in dichotic listening
...................................................................29
2.2.1
Participants
...........................................................................................................................29
2.2.2
Handedness and laterality index for dichotic listening
........................................................30
2.2.3
Nicotine
dependency
...........................................................................................................
ЗО
2.2.4
Procedure
.............................................................................................................................31
2.2.5
Statistical analyses
...............................................................................................................32
2.3
Language lateralization in smoking and non-smoking schizophrenia patients
...........................33
2.3.1
Participants
...........................................................................................................................33
2.3.2
Dichotic listening tasks
.........................................................................................................36
2.3.2.1
Phonemic dichotic listening task
......................................................................37
2.3.2.2
Emotional dichotic listening task
.....................................................................37
2.3.3
Procedure
.............................................................................................................................38
2.3.4
Statistical analysis
.................................................................................................................38
2.3.5
Outlier exclusion and missing data
......................................................................................39
2.4
Smoking effects on attention networks in schizophrenia
...........................................................40
2.4.1
Participants
...........................................................................................................................40
2.4.2
Cognitive test battery
...........................................................................................................41
2.4.3
Statistical analyses
...............................................................................................................44
Chapter
3..............................................................................45
Results
...............................................................................................................................................45
3.1
The neural mechanismsofdichotic listening
..............................................................................46
3.1.1
The effectiveness of the experimental set-up and design
...................................................46
3.1.2
Behavioral data
....................................................................................................................46
3.1.2.1
Laterality index
.................................................................................................46
3.1.2.2
Dichotic listening behavioral results
................................................................46
3.1.2.3
Test-retest reliability
........................................................................................47
3.1.3
Electrophysiological findings
................................................................................................47
3.1.3.1
Amplitudes ofERPs in three time windows
.....................................................49
3.1.3.2
Latency of ERP in three time windows
............................................................53
3.2
Sex-specific effects of smoking in dichotic listening
...................................................................57
3.2.1
Laterality index
.....................................................................................................................57
3.2.2
Dichotic stimuli analyses
......................................................................................................57
3.2.3
Homonym stimuli analysis
...................................................................................................61
3.2.4
Correlational analyses
..........................................................................................................62
3.3
Language lateralization in smoking and non-smoking schizophrenia patients
...........................64
3.3.1
Validity of dichotic listening tasks
........................................................................................64
3.3.2
Phonemic dichotic listening
.................................................................................................64
3.3.3
Emotional dichotic listening
.................................................................................................69
3.4
Smoking
effects on attention networks in schizophrenia
...........................................................73
3.4.1
Sustained attention (CPT-IP)
................................................................................................73
3.4.2
Selective attention (ANT)
.....................................................................................................73
3.4.3
Executive attention (WCST)
..................................................................................................75
Chapter
4..............................................................................76
Discussion
..........................................................................................................................................76
4.1.
The neural mechanisms of dichotic listening
.............................................................................77
4.1.1
Behavioral data
....................................................................................................................77
4.1.2
Electrophysiological results
..................................................................................................78
4.1.2.1
Early time window
............................................................................................78
4.1.2.2
Intermediate time window
................................................................................79
4.1.2.3
Late time window
.............................................................................................79
4.1.3
Anatomy and functional aspects
..........................................................................................80
4.1.4
The centrofrontal shift in the temporal domain
..................................................................81
4.1.5
Conclusion
............................................................................................................................81
4.2
Sex-specific effects of smoking in dichotic listening
...................................................................83
4.2.1
Possible neurobiological mechanisms
..................................................................................87
4.2.2
Summary and Outlook
.........................................................................................................89
4.3
Language lateralization in smoking and non-smoking schizophrenia patients
...........................91
4.3.1
Validity of tasks
....................................................................................................................91
4.3.2
Smoking affects laterally
.....................................................................................................91
4.3.3
Language laterally in schizophrenia
....................................................................................93
4.3.4.
Conclusion
...........................................................................................................................95
4.4
Smoking effects on attention networks in schizophrenia
...........................................................96
4.5
General discussion
....................................................................................................................100
4.5.1
The critical role of
cal losa
I transfer
....................................................................................100
4.5.2
A neurobiological model of smoking related to the cholinergic system
............................101
4.5.3
A neurobiological model of smoking related to the dopamingergic system
.....................104
4.5.4
Final Conclusion
.................................................................................................................105
Bibliography
.......................................................................106
Appendix A: Curriculum
vitae
.........................................130
Appendix B: Publications
..................................................131
Appendix C: Acknowledgements
......................................134
|
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| indexdate | 2024-07-10T00:22:01Z |
| institution | BVB |
| language | English |
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| physical | VII, 136 Bl. Ill., graph. Darst. |
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| spelling | Hahn, Constanze Verfasser (DE-588)143431048 aut Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants by Constanze Hahn 2011 VII, 136 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Bochum, Univ., Diss., 2011 Sprache (DE-588)4056449-6 gnd rswk-swf Rauchen (DE-588)4048539-0 gnd rswk-swf Lateralität (DE-588)4034673-0 gnd rswk-swf Schizophrenie (DE-588)4052527-2 gnd rswk-swf Aufmerksamkeit (DE-588)4068943-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Rauchen (DE-588)4048539-0 s Schizophrenie (DE-588)4052527-2 s Lateralität (DE-588)4034673-0 s Sprache (DE-588)4056449-6 s Aufmerksamkeit (DE-588)4068943-8 s DE-604 Digitalisierung UB Augsburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025195592&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hahn, Constanze Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants Sprache (DE-588)4056449-6 gnd Rauchen (DE-588)4048539-0 gnd Lateralität (DE-588)4034673-0 gnd Schizophrenie (DE-588)4052527-2 gnd Aufmerksamkeit (DE-588)4068943-8 gnd |
| subject_GND | (DE-588)4056449-6 (DE-588)4048539-0 (DE-588)4034673-0 (DE-588)4052527-2 (DE-588)4068943-8 (DE-588)4113937-9 |
| title | Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants |
| title_auth | Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants |
| title_exact_search | Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants |
| title_full | Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants by Constanze Hahn |
| title_fullStr | Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants by Constanze Hahn |
| title_full_unstemmed | Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants by Constanze Hahn |
| title_short | Differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants |
| title_sort | differential role of smoking on language lateralization and attention processes in schizophrenia patients and control participants |
| topic | Sprache (DE-588)4056449-6 gnd Rauchen (DE-588)4048539-0 gnd Lateralität (DE-588)4034673-0 gnd Schizophrenie (DE-588)4052527-2 gnd Aufmerksamkeit (DE-588)4068943-8 gnd |
| topic_facet | Sprache Rauchen Lateralität Schizophrenie Aufmerksamkeit Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025195592&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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