Metal complex DNA interactions:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 524, [12] S. Ill., graph. Darst. |
| ISBN: | 9781405176293 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804140777547235328 |
|---|---|
| adam_text | Titel: Metal complex DNA interactions
Autor: Hadjiliadis, Nick D.
Jahr: 2009
Contents
Preface Page xiii
List of Contributors xv
Acknowledgements xix
A Basic Structural and Kinetic Aspects 1
1 Sequence-Selective Binding of Transition Metal Complexes to DNA 3
Einar Sletten and Nils Age Fr0ystein
1.1 Introduction 3
1.2 Ab initio Calculations and Photo-Cleavage Studies 6
1.3 NMR Spectroscopic Studies of Metal Binding to DNA
Oligonucleotides 9
1.4 Summary of Theoretical and Experimental Evidence for
Sequence-Selective Binding to DNA 22
1.5 Sequence-Specific Groove Binding 22
Abbreviations 26
References 26
2 Thermodynamic Models of Metal Ion-DNA Interactions 31
Vasil Bregadze, Eteri Gelagutashvili and Ketevan Tsakadze
2.1 Introduction 31
2.2 Interactions of Metal Ions with DNA 33
2.3 Model and Mechanisms of Metal-Induced Formation of
Point Defects 43
2.4 Conclusions 48
Acknowledgements 49
Abbreviations 49
References 50
viii Contents
3 Metal Ion Coordination in G-Quadruplexes 55
Janez Plavec
3.1 Introduction 55
3.2 Cation Coordination and Stability of G-Quadruplexes 59
3.3 Structure of Sequences Consisting of Human Telomere Repeats 61
3.4 G-Quadruplexes Adopted by Promoter Regions 64
3.5 Bimolecular G-Quadruplexes of Analogues of the Oxytricha
Telomere Repeat 67
3.6 Coordination of Cations within d[(TG4T)4] 69
3.7 Coordination of Cations within d[(G4T4G4)2] 73
3.8 Cation Movement within G-Quadruplexes 78
3.9 Summary 80
Acknowledgements 81
References 81
4 Supramolecular Chemistry of Metal-Nucleobase Complexes 95
P. J. Sanz Miguel, P. Amo-Ochoa, O. Castillo, A. Houlton and
F. Zamora
4.1 Introduction 95
4.2 Discrete Architectures 98
4.3 Infinite Architectures 108
4.4 Overview of Metal Coordination Sites and Base-Base
Hydrogen Bonding 121
4.5 M-DNA 124
4.6 Conclusion 127
Acknowledgements 127
References 128
B Medical Applications 133
5 Platinum Drugs, Nucleotides and DNA: The Role of Interligand
Interactions 135
Giovanni Natile and Francesco Cannito
5.1 Introduction 135
5.2 Internucleotide Interactions 145
5.3 Guanine cis Amine Interactions 149
5.4 Solid-State Structures of Dynamic Nucleotides 150
5.5 Conformer Distribution in Cisplatin Adducts of G Derivatives 151
5.6 Retro Models Applied to Adducts with Tethered Guanine Bases 156
5.7 Conclusions and Perspectives 163
Acknowledgements 164
References 164
6 Role of DNA Repair in Antitumour Effects of Platinum Drugs 175
Viktor Brabec and Jana Kaspdrkovd
6.1 Introduction 175
6.2 Human DNA Repair Systems 177
Contents ix
6.3 Specific Binding of Repair Proteins to DNA Modified by
Antitumour Platinum Compounds 188
6.4 Repair of DNA Damage by Antitumour Platinum Compounds 193
6.5 Implications for Design of New Antitumour Platinum
Compounds 200
Acknowledgements 201
References 201
7 Telomeres and Telomerase: Potential Targets for Platinum
Complexes 209
Isabelle Ourliac-Gamier, Razan Charifand Sophie Bombard
7.1 Function of Telomeres 209
7.2 Structure of Telomeres 210
7.3 Telomerase 212
7.4 G-Quadruplex Structures and Small Molecules 213
7.5 Cisplatin 216
7.6 Interaction of Cisplatin and Related Platinum Complexes with
G-Quadruplex Structures 217
7.7 Interaction of Cisplatin and Related Platinum Complexes with
Telomeric DNA Duplexes 223
7.8 Interaction of Cisplatin and Related Platinum Complexes with
Telomerase 223
7.9 Conclusion 225
Acknowledgements 226
Abbreviations 226
References 226
8 Towards Photodynamic Therapy of Cancer with Platinum
Group Metal Polyazine Complexes 235
David F. Zigler and Karen J. Brewer
8.1 Introduction 235
8.2 Study of Photophysics: Towards PDT 239
8.3 Photochemical Reactions of Metal Complexes with DNA 255
8.4 Designing Transition Metal Polyazines for DNA
Photomodification 257
8.5 Cell Studies with Metal Complexes 263
8.6 Conclusions and Future Directions 266
Acknowledgements 267
Abbreviations 268
References 269
9 Platinated Oligonucleotides: Synthesis and Applications
for the Control of Gene Expression 273
Vicente Marchdn and Anna Grandas
9.1 Therapeutic Applications of Synthetic Oligonucleotides 273
9.2 Platination as a Tool to Enhance Biological Effects 276
x Contents
9.3 Synthesis of Platinated Oligonucleotides 279
9.4 Use of Platinated Oligonucleotides for Duplex Crosslinking 289
9.5 Use of Platinated Oligonucleotides for Triplex Crosslinking 294
References 295
10 Rhodium- and Tin-DNA Interactions and Applications 301
Kenneth D. Camm and Patrick C. McGowan
10.1 Introduction 301
10.2 Metal-DNA Interactions 302
10.3 Rhodium-DNA Interactions 302
10.4 Tin-DNA Interactions 308
References 311
C DNA Recognition: Nucleases and Sensors 317
11 Groove-Binding Ruthenium(II) Complexes as Probes of DNA
Recognition 319
Jay den A. Smith, J. Grant Collins and F. Richard Keene
11.1 Introduction 319
11.2 Mononuclear Complexes 320
11.3 Dinuclear Complexes 324
11.4 Potential Biological Significance 338
Abbreviations of Ligands 339
References 340
12 DNA Recognition and Binding by Peptide-Metal Complex
Conjugates 347
Alexandra Myari and Nick Hadjiliadis
12.1 Introduction 347
12.2 Transition Metal Complex-Peptide Conjugates 349
12.3 Metallointercalator-Metallopeptide Conjugates 358
12.4 A Critical Survey and Future Perspectives 359
12.5 Conclusion 362
Abbreviations 362
References 363
13 Artificial Restriction Agents: Hydrolytic Agents for DNA
Cleavage 369
Fabrizio Mancin and Paolo Tecilla
13.1 Introduction 369
13.2 DNA Hydrolysis 370
13.3 Free Ions and Mononuclear Complexes 373
13.4 Bimetallic Complexes 377
13.5 Conjugation with DNA-affine Subunits 380
13.6 Conjugation with Sequence-Selective Elements 384
13.7 The ARCUT System 385
13.8 A Critical Survey and New Perspectives 386
Contents sd
13.9 Conclusions 389
Acknowledgements 389
References 390
14 New Metallo-DNAzymes: Fundamental Studies of Metal-DNA
Interactions and Metal Sensing Applications 395
Zehui Cao and Yi Lu
14.1 Introduction 395
14.2 Metal Ions as Important Cofactors of DNAzymes 396
14.3 Selection of DNAzymes Using in vitro Evolution 397
14.4 Understanding Nucleic Acid Enzyme-Metal Ion Interactions 399
14.5 DNAzymes as Metal Ion Sensors 403
14.6 Summary 410
Acknowledgements 411
References 411
15 Two-Metal-Ion-Dependent Catalysis in Nucleic Acid Enzymes 415
Wei Yang
15.1 Chemistry of Nucleic Acid Synthesis, Cleavage and
Strand Transfer 415
15.2 All DNA and RNA Polymerases Require Two Mg2+ Ions
for Catalysis 417
15.3 Nucleases That Require Two Mg2+ Ions in the Active Site 420
15.4 Advantages of Two-Metal-Ion Catalysis: Specificity and Versatility 428
15.5 Concluding Remarks 430
Acknowledgements 430
References 430
D TOXICOLOGICAL ASPECTS 437
16 Structural Studies on the Mercury -Mediated T-T Base-Pair Using
NMR Spectroscopy 439
Yoshiyuki Tanaka andAkira Ono
16.1 The History of the Mercury -Mediated Thymine-Thymine
Base Pair 439
16.2 Crystallographic Studies On Hg -Nucleobase Complexes 440
16.3 UV, UVCD and Vibrational (Ir/Raman) Spectral Studies 441
16.4 NMR Spectral Studies 444
16.5 Relationship Between 15n Chemical Shifts and Chemical Bonds 452
16.6 Applications of the T-Hg -T Base Pair 454
16.7 Biological Relevance ofT-Hg -T Base Pairs 455
16.8 Concluding Remarks 457
References 457
17 Chromium-Induced DNA Damage and Repair 463
Laura G. Little and Kent D. Sugden
17.1 Introduction 463
17.2 Nucleobase Oxidation 468
xii Contents
17.3 Sugar Oxidation 474
17.4 Chromium-DNA Binding 477
17.5 Cr(VI)-Induced DNA Crosslinks 480
17.6 Conclusions 482
References 483
18 Arsenic-Induced Carcinogenicity: New Insights in Molecular
Mechanism 491
Andrea Hartwig and Tanja Schwerdtle
18.1 Introduction 491
18.2 Carcinogenicity and Cocarcinogenicity 492
18.3 Metabolism of Inorganic Arsenic 492
18.4 Modes of Action 494
18.5 Conclusions and Research Needs 499
Acknowledgements 499
Abbreviations 502
References 503
Index 511
|
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| spelling | Metal complex DNA interactions ed. by Nick Hadjiliadis ... Metal complex-DNA interactions Chichester [u.a.] Wiley 2009 XVII, 524, [12] S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Organometallic Compounds pharmacology Organometallic Compounds chemistry Metals therapeutic use DNA chemistry Antineoplastic Agents therapeutic use Neoplasms | drug therapy DNA-ligand interactions Neoplasms drug therapy Organometallic compounds DNS (DE-588)4070512-2 gnd rswk-swf Wechselwirkung (DE-588)4064937-4 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Metallorganische Verbindungen (DE-588)4038906-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Metallorganische Verbindungen (DE-588)4038906-6 s DNS (DE-588)4070512-2 s Wechselwirkung (DE-588)4064937-4 s DE-604 Pharmakologie (DE-588)4045687-0 s Hadjiliadis, Nick D. 1941- (DE-588)138038996 edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018679788&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Metal complex DNA interactions Organometallic Compounds pharmacology Organometallic Compounds chemistry Metals therapeutic use DNA chemistry Antineoplastic Agents therapeutic use Neoplasms | drug therapy DNA-ligand interactions Neoplasms drug therapy Organometallic compounds DNS (DE-588)4070512-2 gnd Wechselwirkung (DE-588)4064937-4 gnd Pharmakologie (DE-588)4045687-0 gnd Metallorganische Verbindungen (DE-588)4038906-6 gnd |
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| title | Metal complex DNA interactions |
| title_alt | Metal complex-DNA interactions |
| title_auth | Metal complex DNA interactions |
| title_exact_search | Metal complex DNA interactions |
| title_full | Metal complex DNA interactions ed. by Nick Hadjiliadis ... |
| title_fullStr | Metal complex DNA interactions ed. by Nick Hadjiliadis ... |
| title_full_unstemmed | Metal complex DNA interactions ed. by Nick Hadjiliadis ... |
| title_short | Metal complex DNA interactions |
| title_sort | metal complex dna interactions |
| topic | Organometallic Compounds pharmacology Organometallic Compounds chemistry Metals therapeutic use DNA chemistry Antineoplastic Agents therapeutic use Neoplasms | drug therapy DNA-ligand interactions Neoplasms drug therapy Organometallic compounds DNS (DE-588)4070512-2 gnd Wechselwirkung (DE-588)4064937-4 gnd Pharmakologie (DE-588)4045687-0 gnd Metallorganische Verbindungen (DE-588)4038906-6 gnd |
| topic_facet | Organometallic Compounds pharmacology Organometallic Compounds chemistry Metals therapeutic use DNA chemistry Antineoplastic Agents therapeutic use Neoplasms | drug therapy DNA-ligand interactions Neoplasms drug therapy Organometallic compounds DNS Wechselwirkung Pharmakologie Metallorganische Verbindungen Aufsatzsammlung |
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