Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat: = Comparison between azothioprine and mycophenolate immunosuppressive regime
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 63 S. graph. Darst. 21 cm |
Internformat
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| 245 | 1 | 0 | |a Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat |b = Comparison between azothioprine and mycophenolate immunosuppressive regime |c vorgelegt von Elmukhtar M. Ali Habas |
| 246 | 1 | 1 | |a Comparison between azothioprine and mycophenolate immunosuppressive regime |
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Datensatz im Suchindex
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| adam_text | 4
CONTENT
page
Abstract 6
1. Introduction. 7
1.1. Organs sources. 7
1.2. Preparation for organ transplantation. 7
1.3. Transplanted organ fate. 8
1.4 Body defence system. 8
1.4.1. Cellular immunity (delayed immunity). 8
1.4.2. Humoral immunity. 9
1.5. Rejection prevention. 10
1.6. Kidney transplantation. 10
1.6.1. Indications of renal transplantation. 10
1.6.2. Kidney sources. 12
1.6.2.1. Living donor. 12
1.6.2.1.1. Assessment of the potentially lived donor for kidney. 12
1.6.2.1.2. HLA typing and incompatibility. 13
1.6.2.1.1.3. Donor exclusion criteria for renal transplantation. 14
1.6.2.1.1.4. Complications of kidney removal. 14
1.6.2.2. Died donor (Cadaveric kidney). 15
1.6.2.2.1. Assessment of potentially donor for cadaveric kidney. 15
1.6.2.2.1. 1. Brain death. 15
1.6.2.1.1.1. Clinical assessment for brain death. 16
1.6.2.1.1.2. Confirmatory investigations of brain death. 16
1.6.3. Recipient assessment for kidney transplantation 16
1.6.3.1. History and clinical examination. 17
1.6.3.2. Investigation 17
| 1.7. Transplanted kidney malfunctioning. 18
1.8. Kidney rejection prevention. 18
1.8.1. Immune system suppression in kidney transplantation. 18
1.8.1.1. Immune suppressive induction. 18
1.8.1.2.Immune suppression maintenance after renal transplantation. 19
1.8.1.2.1. Cyclosporine. 20
1.8.1.2.2. Corticosteroid. 21
1.8.1.2.3. Mycophenolate (CellCept). 21
1.8.1.2.3.1 Mechanism of action 21
1.8.1.2.3.2 Mycophenolate excretion 21
1.8.1.2.3.3 Drug interaction 22
1.8.1.2.3.4 Mycophenolate side effects 22
1.8.1.2.4. Azathioprine. 23
1.8.1.2.4.1 Mechanism of action 23
1.8.1.2.4.2 Drug dosing 24
1.8.1.2.4.3 Side effects 24
2. Back ground and aim of the study. 26
3. Methods 27
4. Results 28
4.1. Haematological responses. 28
I
5
4.1.1. Leucocytes (WBC). 29
4.1.2. Absolute Lymphocyte. 30
4.1.3. Thrombocyte. 31
4.1.4. Haemoglobin. 32
4.1.5. Packed cell volume. 33
4.1.6. Mean corpuscular volume, delta MCV and azathioprine doses. 34
4.2. Kidney function tests. 36
4.2.1. Serum creatinine. 36
4.2.2. Serum urea. 35
4.2.3. Urine creatinine. 36
4.2.4. Creatinine clearance. 37
4.2.5. Daily urinary creatinine excretion. 37
4.2.5. Urine Protein. 38
4.3. Serum liver enzymes. 38
4.3.1. Alanine aminotransferase, aspartae aminotransferase (GOT, GPT) and Gama-
GLutamyl tanspeptidase(Gama-GT) enzymes. 38
4.3.2. Alkaline phosphatase and Lactat dehydrogenase enzyme (LDH AP). 41
4.4. Iron body status. 42
4.4.1. Serum iron and transferrin saturation. 42
4.5. Physical parameters. 43
4.5.1. Systolic, diastolic and mean blood pressure (mmHg). 44
4.5.2. Body weight (Kg). 45
5. Discussion. 47
6. Summary 52
7. Zusammenfassung 53
8.References. 62
9.Curriculum vitae
|
| adam_txt |
4
CONTENT
page
Abstract 6
1. Introduction. 7
1.1. Organs sources. 7
1.2. Preparation for organ transplantation. 7
1.3. Transplanted organ fate. 8
1.4 Body defence system. 8
1.4.1. Cellular immunity (delayed immunity). 8
1.4.2. Humoral immunity. 9
1.5. Rejection prevention. 10
1.6. Kidney transplantation. 10
1.6.1. Indications of renal transplantation. 10
1.6.2. Kidney sources. 12
1.6.2.1. Living donor. 12
1.6.2.1.1. Assessment of the potentially lived donor for kidney. 12
1.6.2.1.2. HLA typing and incompatibility. 13
1.6.2.1.1.3. Donor exclusion criteria for renal transplantation. 14
1.6.2.1.1.4. Complications of kidney removal. 14
1.6.2.2. Died donor (Cadaveric kidney). 15
1.6.2.2.1. Assessment of potentially donor for cadaveric kidney. 15
1.6.2.2.1. 1. Brain death. 15
1.6.2.1.1.1. Clinical assessment for brain death. 16
1.6.2.1.1.2. Confirmatory investigations of brain death. 16
1.6.3. Recipient assessment for kidney transplantation 16
1.6.3.1. History and clinical examination. 17
1.6.3.2. Investigation 17
| 1.7. Transplanted kidney malfunctioning. 18
1.8. Kidney rejection prevention. 18
1.8.1. Immune system suppression in kidney transplantation. 18
1.8.1.1. Immune suppressive induction. 18
1.8.1.2.Immune suppression maintenance after renal transplantation. 19
1.8.1.2.1. Cyclosporine. 20
1.8.1.2.2. Corticosteroid. 21
1.8.1.2.3. Mycophenolate (CellCept). 21
1.8.1.2.3.1 Mechanism of action 21
1.8.1.2.3.2 Mycophenolate excretion 21
1.8.1.2.3.3 Drug interaction 22
1.8.1.2.3.4 Mycophenolate side effects 22
1.8.1.2.4. Azathioprine. 23
1.8.1.2.4.1 Mechanism of action 23
1.8.1.2.4.2 Drug dosing 24
1.8.1.2.4.3 Side effects 24
2. Back ground and aim of the study. 26
3. Methods 27
4. Results 28
4.1. Haematological responses. 28
I
5
4.1.1. Leucocytes (WBC). 29
4.1.2. Absolute Lymphocyte. 30
4.1.3. Thrombocyte. 31
4.1.4. Haemoglobin. 32
4.1.5. Packed cell volume. 33
4.1.6. Mean corpuscular volume, delta MCV and azathioprine doses. 34
4.2. Kidney function tests. 36
4.2.1. Serum creatinine. 36
4.2.2. Serum urea. 35
4.2.3. Urine creatinine. 36
4.2.4. Creatinine clearance. 37
4.2.5. Daily urinary creatinine excretion. 37
4.2.5. Urine Protein. 38
4.3. Serum liver enzymes. 38
4.3.1. Alanine aminotransferase, aspartae aminotransferase (GOT, GPT) and Gama-
GLutamyl tanspeptidase(Gama-GT) enzymes. 38
4.3.2. Alkaline phosphatase and Lactat dehydrogenase enzyme (LDH AP). 41
4.4. Iron body status. 42
4.4.1. Serum iron and transferrin saturation. 42
4.5. Physical parameters. 43
4.5.1. Systolic, diastolic and mean blood pressure (mmHg). 44
4.5.2. Body weight (Kg). 45
5. Discussion. 47
6. Summary 52
7. Zusammenfassung 53
8.References. 62
9.Curriculum vitae |
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| author | Habas, Elmukhtar M. Ali 1962- |
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| dewey-ones | 617 - Surgery & related medical specialties |
| dewey-raw | 617.46 |
| dewey-search | 617.46 |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| spelling | Habas, Elmukhtar M. Ali 1962- Verfasser (DE-588)136381901 aut Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime vorgelegt von Elmukhtar M. Ali Habas Comparison between azothioprine and mycophenolate immunosuppressive regime 2008 63 S. graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Köln, Univ., Diss., 2008 (DE-588)4113937-9 Hochschulschrift gnd-content HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016776794&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Habas, Elmukhtar M. Ali 1962- Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime |
| subject_GND | (DE-588)4113937-9 |
| title | Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime |
| title_alt | Comparison between azothioprine and mycophenolate immunosuppressive regime |
| title_auth | Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime |
| title_exact_search | Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime |
| title_exact_search_txtP | Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime |
| title_full | Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime vorgelegt von Elmukhtar M. Ali Habas |
| title_fullStr | Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime vorgelegt von Elmukhtar M. Ali Habas |
| title_full_unstemmed | Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat = Comparison between azothioprine and mycophenolate immunosuppressive regime vorgelegt von Elmukhtar M. Ali Habas |
| title_short | Vergleich zwischen einer immunsuppressiven Therapie mit Azathioprin oder Mycophenolat |
| title_sort | vergleich zwischen einer immunsuppressiven therapie mit azathioprin oder mycophenolat comparison between azothioprine and mycophenolate immunosuppressive regime |
| title_sub | = Comparison between azothioprine and mycophenolate immunosuppressive regime |
| topic_facet | Hochschulschrift |
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