The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Freiburg im Breisgau
2018
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Enthält Sonderabdrucke |
| Beschreibung: | IV, 110 Seiten Illustrationen, Diagramme 30 cm |
Internformat
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| 245 | 1 | 0 | |a The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA |c vorgelegt von Laura Brigitte Graf |
| 264 | 1 | |a Freiburg im Breisgau |c 2018 | |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
DANKSAGUNG I
1 SUMMARY 1
2 ZUSAMMENFASSUNG 3
3 INTRODUCTION 5
3.1 INFLUENZA A VIRUS AND THOGOTO VIRUS: TWO REPRESENTATIVES OF THE
ORTHOMYXOVIRIDAE FAMILY 5
3.2 THE BUNYAVIRUSES LA CROSSE VIRUS AND RIFT VALLEY FEVER VIRUS 9
3.3 VESICULAR STOMATITIS VIRUS 12
3.4 HUMAN MYXOVIRUS RESISTANCE PROTEIN A (MXA) 15
3.4.1 STRUCTURE OF MXA AND OLIGOMERIZATION 17
3.4.2 MEMBRANE BINDING OF MXA 22
3.4.3 GTPASE ACTIVITY OF MXA 23
3.4.4 ANTIVIRAL ACTIVITY OF MXA 26
3.4.4.1 ANTIVIRAL ACTIVITY AGAINST ORTHOMYXOVIRUSES 26
3.4.4 2 ANTIVIRAL ACTIVITY AGAINST BUNYAVIRUSES 28
3.4.4.3 ANTIVIRAL ACTIVITY AGAINST VESICULAR STOMATITIS VIRUS 28
3.4.4 4 MODEL OF MXA ANTIVIRAL ACTION 29
3.4.5 THE ANTIVIRAL SPECIFICITY OF MXA AND MXA SENSITIVITY OF FLUAV 29
3.5 GENETIC VARIATION AND SUSCEPTIBILITY TO VIRAL INFECTIONS 30
4 THESIS OBJECTIVES 33
5 SUMMARY OF RESULTS AND DISCUSSION 34
5.1 THE GTPASE MECHANISM OF MXA 34
5.1.1 DIMERIZATION OF MXA G DOMAINS VIA THE CONSERVED G INTERFACE IS
REQUIRED FOR GTP HYDROLYSIS. 34
5.1.2 THE ROLE OF GTP BINDING AND HYDROLYSIS FOR THE ANTIVIRAL FUNCTION
OF
MXA 39
5.1.3 THE ROLE OF GTP BINDING AND HYDROLYSIS FOR MEMBRANE-ASSOCIATED
ASSEMBLY OF MXA 40
5.1.4 DUAL ROLE OF GTPASE ACTIVITY IN MXA FUNCTION 40
5.2 EFFECTS OF ALLELIC VARIATIONS IN MXA ON ITS ANTIVIRAL ACTIVITY 41
5.2.1 VARIATIONS IN THE G INTERFACE AFFECT ANTIVIRAL ACTIVITY AND GTP
HYDROLYSIS 42
5.2.2 VARIATIONS IN THE STALK CAN LEAD TO ALTERED ANTIVIRAL ACTIVITY AND
SPECIFICITY OF MXA 45
5.2.3 THE EFFECTS OF INACTIVE, HETEROZYGOUS VARIANTS ON THE WT ALLELE 47
5.2.4 MXA AND INTER-INDIVIDUAL VARIABILITY IN VIRAL DISEASES 48
6 ORIGINAL PUBLICATIONS 50
6.1 ROLE OF NUCLEOTIDE BINDING AND GTPASE DOMAIN DIMERIZATION IN
DYNAMIN-LIKE MYXOVIRUS RESISTANCE PROTEIN A FOR GTPASE ACTIVATION
AND ANTIVIRAL ACTIVITY 50
6.2 EFFECTS OF ALLELIC VARIATIONS IN THE HUMAN MYXOVIRUS RESISTANCE
PROTEIN A
ON ITS ANTIVIRAL ACTIVITY 65
7 REFERENCES 90
8 APPENDIX 106
8.1 LIST OF ABBREVIATIONS 106
8.2 LIST OF FIGURES 107
8.3 LIST OF TABLES 107
8.4 PUBLICATIONS 108
8.5 CONFERENCE CONTRIBUTIONS 109
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| author | Graf, Laura Brigitte |
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| bvnumber | BV045303691 |
| ctrlnum | (OCoLC)1136409395 (DE-599)BSZ506837343 |
| discipline | Biologie Medizin |
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| indexdate | 2024-07-10T08:14:21Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030690793 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | IV, 110 Seiten Illustrationen, Diagramme 30 cm |
| publishDate | 2018 |
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| spelling | Graf, Laura Brigitte Verfasser (DE-588)1161744649 aut The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA vorgelegt von Laura Brigitte Graf Freiburg im Breisgau 2018 IV, 110 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Enthält Sonderabdrucke Dissertation Albert-Ludwigs-Universität Freiburg im Breisgau 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1163762555/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030690793&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Graf, Laura Brigitte The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA |
| subject_GND | (DE-588)4113937-9 |
| title | The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA |
| title_auth | The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA |
| title_exact_search | The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA |
| title_full | The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA vorgelegt von Laura Brigitte Graf |
| title_fullStr | The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA vorgelegt von Laura Brigitte Graf |
| title_full_unstemmed | The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA vorgelegt von Laura Brigitte Graf |
| title_short | The role of the GTPase mechanism and of naturally occurring variations for the antiviral activity of MxA |
| title_sort | the role of the gtpase mechanism and of naturally occurring variations for the antiviral activity of mxa |
| topic_facet | Hochschulschrift |
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