The reeler mouse as a model of brain development: with 3 tables
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1998
|
| Schriftenreihe: | Advances in anatomy, embryology, and cell biology
150 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 108 S. Ill., graph. Darst. |
| ISBN: | 3540646744 |
Internformat
MARC
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| 245 | 1 | 0 | |a The reeler mouse as a model of brain development |b with 3 tables |c C. Lambert de Rouvroit and A. M. Goffinet |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1998 | |
| 300 | |a XI, 108 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in anatomy, embryology, and cell biology |v 150 | |
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Datensatz im Suchindex
| _version_ | 1807323359119147008 |
|---|---|
| adam_text |
CONTENTS
1
BRAIN
DEVELOPMENT
IN
NORMAL
AND
REELER
MICE:
THE
PHENOTYPE
.
1
1.1
SOME
INTRODUCTORY
BACKGROUND
.
1
1.2
THE
EARLY
DEVELOPMENT
OF
THE
NORMAL
CEREBRAL
CORTEX
.
2
1.2.1
ORIENTATION
OF
MITOSES
IN
THE
VENTRICULAR
ZONE
.
4
1.2.2
THE
PREPLATE
.
6
1.2.3
THE
EARLY
MARGINAL
ZONE
.
7
1.2.4
THE
APPEARANCE
OF
THE
CORTICAL
PLATE
.
7
1.3
EARLY
CORTICAL
HISTOGENESIS
IN
REELER
MUTANT
MICE
.
8
1.4
THE
REELER
CEREBELLUM
.
12
1.5
THE
REELER
INFERIOR
OLIVARY
COMPLEX
.
15
1.6
THE
FACIAL
NERVE
NUCLEUS
AND
OTHER
TARGETS
.
18
1.6.1
OTHER
TARGETS
OF
THE
REELER
GENE.
.
20
1.7
ECM
COMPONENTS
AND
CORTICAL
DEVELOPMENT
.
.
22
1.7.1
ECM
AND
FIBER
GROWTH
.
24
1.7.2
INTEGRINS
.
25
2
GENETICS
OF
REELER
AND
GENOMICS
OF
REELIN
.
27
2.1
GENETICS
AND
THE
VARIOUS
ALLELES
OF
REELER
.
27
2.1.1
RAT
REELER-LIKE
MUTATIONS
.
29
2.1.2
OTHER
MOUSE
MUTATIONS
WITH
A
REELER-LIKE
PHENOTYPE
.
30
2.2
MAPPING
OF
REELER
AND
CLONING
OF
REELIN
.
30
2.2.1
MAPPING
.
30
2.2.2
THE
REELIN
CDNA
.
32
2.3
GENOMIC
ORGANIZATION
OF
THE
REELIN
GENE
.
34
2.3.1
ALTERNATIVE
SPLICING
OF
THE
REELIN
GENE
.
34
2.3.1.1
ALTERNATIVE
USE
OF
A
SIX
BASE
PAIR
MICROEXON.
.
34
2.3.1.2
ALTERNATIVE
POLYADENYLATION
.
35
2.3.2
THE
PROMOTER
REGION
.
36
2.3.3
CLUES
TO
THE
POSSIBLE
ORIGIN
OF
THE
REELIN
REPEATS?
.
36
3
TOPOGRAPHY
AND
CELLULAR
LOCALIZATION
OF
REELIN
MRNA
AND
PROTEIN
EXPRESSION
DURING
BRAIN
DEVELOPMENT
.
41
3.1
REELIN
MRNA
EXPRESSION
DURING
DEVELOPMENT
.
41
3.2
STUDY
OF
REELIN
PROTEIN
EXPRESSION
USING
ANTIBODIES
TO
REELIN
.
49
3.2.1
ANTIREELIN
ANTIBODIES
.
49
3.2.2
REELIN
PROTEIN
EXPRESSION
DURING
MOUSE
BRAIN
AND
HUMAN
CORTICAL
DEVELOPMENT
.
51
3.2.3
STUDIES
OF
REELIN
FUNCTION
USING
ANTIREELIN
ANTIBODIES
.
53
3.2.4
IS
THE
REELIN
PROTEIN
PROCESSED
IN
THE
EMBRYONIC
MOUSE
BRAIN?
.
54
3.3
SOME
QUESTIONS
RAISED
BY
THE
STUDIES
OF
REELIN
EXPRESSION
.
55
3.3.1
CAJAL-RETZIUS
CELLS
AND
OTHER
REELIN-POSITIVE
CELLS
IN
THE
DEVELOPING
CORTICAL
MARGINAL
ZONE
.
55
3.3.2
DOES
REELIN
ACT
ON
POSTMIGRATORY
NEURONS,
RADIAL
GLIA
OR
BOTH?
.
56
3.3.3
REELIN
EXPRESSION
IS
POORLY
CORRELATED
WITH
THE
REELER
PHENOTYPE
.
57
3.3.4
REELIN
AS
A
REPULSIVE,
EXTRACELLULAR
MATRIX-EXPANDING
MOLECULE?
.
57
3.3.5
REELIN
AND
AXONAL
GROWTH
.
58
4
THE
REELER
MUTATION
AND
BRAIN
EVOLUTION
.
59
4.1
THE
EVOLUTION
OF
BRAIN
DEVELOPMENT:
A
NEW
THEME?
.
59
4.2
COMPARATIVE
DATA
ON
CELL
MIGRATION,
MATURATION,
SYNAPTOGENESIS
AND
NEUROGENESIS
.
61
4.3
COMPARISON
OF
CORTICAL
PLATE
DEVELOPMENT
IN
EMYS
AND
LACERTA
.
62
4.3.1
BIOLOGICAL
MECHANISMS
INVOLVED
IN
THE
HISTOGENESIS
OF
THE
CORTICAL
PLATE
.
63
4.3.2
EVOLUTIONARY
CONSIDERATIONS
.
63
4.4
REELIN
AND
A
MODEL
OF
CORTICAL
EVOLUTION
.
69
5
A
MODEL
OF
CORTICAL
DEVELOPMENT
INSPIRED
BY
REELER:
FACTS
AND
HYPOTHESES
.
73
5.1
EARLY
HYPOTHESES
ON
THE
ACTIONS
OF
THE
REELER
GENE
ON
THE
DEVELOPING
BRAIN
.
73
5.1.1
REELER
AND
CELL
INTERACTION/ADHESION
.
73
5.1.2
THE
ACTION
OF
THE
REELER
GENE
IS
INTRINSIC
TO
THE
NEUROEPITHELIUM
.
74
5.1.3
REELER
PHENOTYPE
AND
RADIAL
GLIAL
FIBERS
.
75
5.2
MOUSE
DISABLEDL
AND
THE
SCRAMBLER/YOTARI
MUTATIONS.
.
76
5.3
CYCLIN-DEPENDENT
PROTEIN
KINASE
5
AND
ITS
ACTIVATOR
P35:
DEFINITION
OF
A
NEW
STEP
IN
MAMMALIAN
CORTICAL
DEVELOPMENT
.
82
5.4
REELER-TYPE
MALFORMATIONS
AND
HUMAN
NEUROPATHOLOGY
.
84
REFERENCES
.
89
SUBJECT
INDEX
.
107 |
| any_adam_object | 1 |
| author | Lambert de Rouvroit, Catherine 1963- Goffinet, André M. 1950- |
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| dewey-full | 573.8/61935 571 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 573 - Specific physiological systems in animals 571 - Physiology & related subjects |
| dewey-raw | 573.8/61935 571 |
| dewey-search | 573.8/61935 571 |
| dewey-sort | 3573.8 561935 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV012093226 |
| illustrated | Illustrated |
| indexdate | 2024-08-14T01:11:06Z |
| institution | BVB |
| isbn | 3540646744 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008189975 |
| oclc_num | 174341523 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-11 |
| physical | XI, 108 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Springer |
| record_format | marc |
| series | Advances in anatomy, embryology, and cell biology |
| series2 | Advances in anatomy, embryology, and cell biology |
| spelling | Lambert de Rouvroit, Catherine 1963- Verfasser (DE-588)120228114 aut The reeler mouse as a model of brain development with 3 tables C. Lambert de Rouvroit and A. M. Goffinet Berlin [u.a.] Springer 1998 XI, 108 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in anatomy, embryology, and cell biology 150 Gehirn (DE-588)4019752-9 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf Entwicklung (DE-588)4113450-3 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf Organogenese (DE-588)4266352-0 gnd rswk-swf Genmutation (DE-588)4156638-5 gnd rswk-swf Maus (DE-588)4169148-9 s Tiermodell (DE-588)4140660-6 s Gehirn (DE-588)4019752-9 s Organogenese (DE-588)4266352-0 s DE-604 Entwicklung (DE-588)4113450-3 s Genmutation (DE-588)4156638-5 s Goffinet, André M. 1950- Verfasser (DE-588)120228130 aut Advances in anatomy, embryology, and cell biology 150 (DE-604)BV002528506 150 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008189975&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lambert de Rouvroit, Catherine 1963- Goffinet, André M. 1950- The reeler mouse as a model of brain development with 3 tables Advances in anatomy, embryology, and cell biology Gehirn (DE-588)4019752-9 gnd Tiermodell (DE-588)4140660-6 gnd Entwicklung (DE-588)4113450-3 gnd Maus (DE-588)4169148-9 gnd Organogenese (DE-588)4266352-0 gnd Genmutation (DE-588)4156638-5 gnd |
| subject_GND | (DE-588)4019752-9 (DE-588)4140660-6 (DE-588)4113450-3 (DE-588)4169148-9 (DE-588)4266352-0 (DE-588)4156638-5 |
| title | The reeler mouse as a model of brain development with 3 tables |
| title_auth | The reeler mouse as a model of brain development with 3 tables |
| title_exact_search | The reeler mouse as a model of brain development with 3 tables |
| title_full | The reeler mouse as a model of brain development with 3 tables C. Lambert de Rouvroit and A. M. Goffinet |
| title_fullStr | The reeler mouse as a model of brain development with 3 tables C. Lambert de Rouvroit and A. M. Goffinet |
| title_full_unstemmed | The reeler mouse as a model of brain development with 3 tables C. Lambert de Rouvroit and A. M. Goffinet |
| title_short | The reeler mouse as a model of brain development |
| title_sort | the reeler mouse as a model of brain development with 3 tables |
| title_sub | with 3 tables |
| topic | Gehirn (DE-588)4019752-9 gnd Tiermodell (DE-588)4140660-6 gnd Entwicklung (DE-588)4113450-3 gnd Maus (DE-588)4169148-9 gnd Organogenese (DE-588)4266352-0 gnd Genmutation (DE-588)4156638-5 gnd |
| topic_facet | Gehirn Tiermodell Entwicklung Maus Organogenese Genmutation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008189975&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002528506 |
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