Thyroid systems engineering :: a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis /
Targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology.
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Gistrup, Denmark :
River Publishers,
[2018]
|
| Schriftenreihe: | River Publishers series in biomedical engineering.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology. |
| Beschreibung: | 9.1 Introduction. |
| Beschreibung: | 1 online resource |
| Bibliographie: | ReferencesChapter 3-Modeling Principles; 3.1 Introduction; 3.2 Modeling Examples; 3.2.1 Modeling Example 1; 3.3 Electrical Network Representation of the Leaking Water Container; 3.4 Static Modeling; 3.5 Modeling Examples from Solid-state Physics and Electronic Engineering; 3.6 General Appearance and Decay Model with Electrical Network Elements; 3.7 Appearance Time Constant; 3.8 Determining the Value of the Appearance Time Constant; 3.9 Discussion; 3.10 Conclusion; References; Chapter 4-Medical Statistics and Mathematical Modeling Make Strange Bedfellows; 4.1 Introduction. |
| ISBN: | 9788793609587 8793609582 9781003339823 1003339824 9781000792782 1000792781 9781000795943 1000795942 |
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| 245 | 1 | 0 | |a Thyroid systems engineering : |b a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / |c Simon Lucas Goede, Melvin Khee-Shing Leow. |
| 264 | 1 | |a Gistrup, Denmark : |b River Publishers, |c [2018] | |
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| 505 | 0 | |a Front Cover; Half Title Page; RIVER PUBLISHERS SERIES IN BIOMEDICALENGINEERING; Title Page -- Thyroid Systems EngineeringA Primer in Mathematical Modeling of theHypothalamus-Pituitary-Thyroid Axis; Copyright Page; DEDICATION; Contents; Preface; Acknowledgements; List of Figures; List of Tables; List of Abbreviations; Chapter 1 -- General Introduction; 1.1 Introduction; Chapter 2 -- Physiology of the HPT Axis; 2.1 Synopsis of Thyroid Biochemistry and Molecular; 2.2 Operation of the Hypothalamusâ#x80;#x93;Pituitary (HP); 2.3 Thyroid Physiology; 2.4 Physiological Feedback Representation of the HPT. | |
| 504 | |a ReferencesChapter 3-Modeling Principles; 3.1 Introduction; 3.2 Modeling Examples; 3.2.1 Modeling Example 1; 3.3 Electrical Network Representation of the Leaking Water Container; 3.4 Static Modeling; 3.5 Modeling Examples from Solid-state Physics and Electronic Engineering; 3.6 General Appearance and Decay Model with Electrical Network Elements; 3.7 Appearance Time Constant; 3.8 Determining the Value of the Appearance Time Constant; 3.9 Discussion; 3.10 Conclusion; References; Chapter 4-Medical Statistics and Mathematical Modeling Make Strange Bedfellows; 4.1 Introduction. | ||
| 505 | 8 | |a 4.2 Pitfalls in the Application of Inferential Statistical Methods4.2.1 Explanation of the Observed Log-linear Relationship between [TSH] and [FT4]; 4.3 Abuse of Mathematical Models; 4.3.1 Critical Notes; 4.4 Future Developments; 4.5 Conclusion; References; Chapter 5 -- Systems Theory Applied on the Modeling of the HPT Axis and First Principles of Feedback and Homeostasis; 5.1 Introduction; 5.2 Definition of System Components; 5.3 System Dynamics; 5.4 Frequency Response of the First-order Low-pass Section; 5.5 Cascading System Blocks; 5.6 Example of a Feedback System. | |
| 505 | 8 | |a 5.6.1 Feed Forward Compensation5.7 Discussion; References; Chapter 6 -- The Mathematical Relationship between [FT4] and [TSH]; 6.1 Introduction; 6.1.1 History; 6.2 Linear-logarithmic Relationship between [FT4] and [TSH]; 6.3 Modeling the Curved [FT4]â#x80;#x93;[TSH] Characteristic; 6.4 Properties of the Exponential Function; 6.4.1 Effect of the Multiplier Model Parameter S; 6.4.2 Effect of the Exponential Model Parameter '; 6.5 Dynamic Signal Transfer of the HP Characteristic; 6.6 Generalized Expression of the HP Characteristic; 6.7 Discussion; References. | |
| 505 | 8 | |a Chapter 7 -- The Thyroid Gland and the Relationship Between [TSH] and [FT4]7.1 Introduction; 7.2 Model of the Thyroid Gland; 7.3 Discussion; References; Chapter 8 -- The Hypothalamusâ#x80;#x93;Pituitary (HPT) Set Point Theory; 8.1 Introduction; 8.2 The Hypothalamusâ#x80;#x93;Pituitary (HP) Control System; 8.3 Derivation of the Point of Maximum Curvature from the HP Function; 8.4 Theory Behind of the Physiology of the Homeostatic Control Process; 8.5 Point of Maximum Curvature of the Thyroid Characteristic; 8.6 Discussion; References; Chapter 9 -- The Human Hypothalamusâ#x80;#x93;Pituitaryâ#x80;#x93;Thyroid Control System. | |
| 500 | |a 9.1 Introduction. | ||
| 520 | 8 | |a Targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology. |b Through a combination of formal mathematical reasoning and knowledge of the nature of thyroid physiology and supported by in-depth patient observations, this volume hones in on finding optimal treatment for people suffering from thyroid hormone disorders. At the same time, the editors--respectively an electrical engineer and a clinical thyroidoloist--introduce a new discipline aptly designated as Thyroid Systems Engineering. Readers will discover that mathematics can indeed model the behavior of the hypothalamus-pituitary-thyroid (HPT) axis. Focused on modeling, each of the eighteen chapters gives the reader a notion of the application of relevant mathematics to pertinent issues encountered in mainstream thyroidology. Many cellular processes resemble the flux of variables and states in a complex multi-parameter space through time analogous to current flow in electrical networks. It is then logical to apply the principles and physical laws of electrodynamics, electrical network theory, control systems theory and signal theory to many of the biological phenomena encountered in endocrinology. Such an approach is used liberally throughout the book and successfully yields elegant solutions to a number of models presented within. This book can serve as a reference to mathematical modeling in other aspects of endocrine physiology, and as the starting point for a fundamental course in medical modeling. It will appeal to postgraduates in electrical engineering, academic physicians and biomedical researchers. Further, readers equipped with advanced calculus, electrical network theory, control theory and signal theory should be able to follow the mathematical expositions that describe thyrotropic control. These expositions represent a new discipline based on mathematical modeling in physiology which is applicable to medical diagnostics, measurement, and treatment, allowing clinical teams to realize an optimized treatment for patients. | |
| 545 | 0 | |a Simon Goede, Melvin Khee-Shing Leow | |
| 650 | 0 | |a Thyroid gland |x Physiology |x Mathematical models. | |
| 650 | 0 | |a Thyroid gland. |0 http://id.loc.gov/authorities/subjects/sh85135163 | |
| 650 | 0 | |a Mathematical models. |0 http://id.loc.gov/authorities/subjects/sh85082124 | |
| 650 | 2 | |a Thyroid Gland |0 https://id.nlm.nih.gov/mesh/D013961 | |
| 650 | 2 | |a Models, Theoretical |0 https://id.nlm.nih.gov/mesh/D008962 | |
| 650 | 6 | |a Thyroïde |x Physiologie |x Modèles mathématiques. | |
| 650 | 6 | |a Thyroïde. | |
| 650 | 6 | |a Modèles mathématiques. | |
| 650 | 7 | |a mathematical models. |2 aat | |
| 650 | 7 | |a SCIENCE |x Energy. |2 bisacsh | |
| 650 | 7 | |a Physiology |x Mathematical models |2 fast | |
| 700 | 1 | |a Leow, Melvin Khee-Shing, |e author. | |
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| contents | Front Cover; Half Title Page; RIVER PUBLISHERS SERIES IN BIOMEDICALENGINEERING; Title Page -- Thyroid Systems EngineeringA Primer in Mathematical Modeling of theHypothalamus-Pituitary-Thyroid Axis; Copyright Page; DEDICATION; Contents; Preface; Acknowledgements; List of Figures; List of Tables; List of Abbreviations; Chapter 1 -- General Introduction; 1.1 Introduction; Chapter 2 -- Physiology of the HPT Axis; 2.1 Synopsis of Thyroid Biochemistry and Molecular; 2.2 Operation of the Hypothalamusâ#x80;#x93;Pituitary (HP); 2.3 Thyroid Physiology; 2.4 Physiological Feedback Representation of the HPT. 4.2 Pitfalls in the Application of Inferential Statistical Methods4.2.1 Explanation of the Observed Log-linear Relationship between [TSH] and [FT4]; 4.3 Abuse of Mathematical Models; 4.3.1 Critical Notes; 4.4 Future Developments; 4.5 Conclusion; References; Chapter 5 -- Systems Theory Applied on the Modeling of the HPT Axis and First Principles of Feedback and Homeostasis; 5.1 Introduction; 5.2 Definition of System Components; 5.3 System Dynamics; 5.4 Frequency Response of the First-order Low-pass Section; 5.5 Cascading System Blocks; 5.6 Example of a Feedback System. 5.6.1 Feed Forward Compensation5.7 Discussion; References; Chapter 6 -- The Mathematical Relationship between [FT4] and [TSH]; 6.1 Introduction; 6.1.1 History; 6.2 Linear-logarithmic Relationship between [FT4] and [TSH]; 6.3 Modeling the Curved [FT4]â#x80;#x93;[TSH] Characteristic; 6.4 Properties of the Exponential Function; 6.4.1 Effect of the Multiplier Model Parameter S; 6.4.2 Effect of the Exponential Model Parameter '; 6.5 Dynamic Signal Transfer of the HP Characteristic; 6.6 Generalized Expression of the HP Characteristic; 6.7 Discussion; References. Chapter 7 -- The Thyroid Gland and the Relationship Between [TSH] and [FT4]7.1 Introduction; 7.2 Model of the Thyroid Gland; 7.3 Discussion; References; Chapter 8 -- The Hypothalamusâ#x80;#x93;Pituitary (HPT) Set Point Theory; 8.1 Introduction; 8.2 The Hypothalamusâ#x80;#x93;Pituitary (HP) Control System; 8.3 Derivation of the Point of Maximum Curvature from the HP Function; 8.4 Theory Behind of the Physiology of the Homeostatic Control Process; 8.5 Point of Maximum Curvature of the Thyroid Characteristic; 8.6 Discussion; References; Chapter 9 -- The Human Hypothalamusâ#x80;#x93;Pituitaryâ#x80;#x93;Thyroid Control System. |
| ctrlnum | (OCoLC)1027171741 |
| dewey-full | 612.44 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.44 |
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| discipline | Medizin |
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Dynamic Signal Transfer of the HP Characteristic; 6.6 Generalized Expression of the HP Characteristic; 6.7 Discussion; References.</subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">Chapter 7 -- The Thyroid Gland and the Relationship Between [TSH] and [FT4]7.1 Introduction; 7.2 Model of the Thyroid Gland; 7.3 Discussion; References; Chapter 8 -- The Hypothalamusâ#x80;#x93;Pituitary (HPT) Set Point Theory; 8.1 Introduction; 8.2 The Hypothalamusâ#x80;#x93;Pituitary (HP) Control System; 8.3 Derivation of the Point of Maximum Curvature from the HP Function; 8.4 Theory Behind of the Physiology of the Homeostatic Control Process; 8.5 Point of Maximum Curvature of the Thyroid Characteristic; 8.6 Discussion; References; Chapter 9 -- The Human Hypothalamusâ#x80;#x93;Pituitaryâ#x80;#x93;Thyroid Control System.</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">9.1 Introduction.</subfield></datafield><datafield tag="520" ind1="8" ind2=" "><subfield code="a">Targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology.</subfield><subfield code="b">Through a combination of formal mathematical reasoning and knowledge of the nature of thyroid physiology and supported by in-depth patient observations, this volume hones in on finding optimal treatment for people suffering from thyroid hormone disorders. At the same time, the editors--respectively an electrical engineer and a clinical thyroidoloist--introduce a new discipline aptly designated as Thyroid Systems Engineering. Readers will discover that mathematics can indeed model the behavior of the hypothalamus-pituitary-thyroid (HPT) axis. Focused on modeling, each of the eighteen chapters gives the reader a notion of the application of relevant mathematics to pertinent issues encountered in mainstream thyroidology. Many cellular processes resemble the flux of variables and states in a complex multi-parameter space through time analogous to current flow in electrical networks. It is then logical to apply the principles and physical laws of electrodynamics, electrical network theory, control systems theory and signal theory to many of the biological phenomena encountered in endocrinology. Such an approach is used liberally throughout the book and successfully yields elegant solutions to a number of models presented within. This book can serve as a reference to mathematical modeling in other aspects of endocrine physiology, and as the starting point for a fundamental course in medical modeling. It will appeal to postgraduates in electrical engineering, academic physicians and biomedical researchers. Further, readers equipped with advanced calculus, electrical network theory, control theory and signal theory should be able to follow the mathematical expositions that describe thyrotropic control. 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| id | ZDB-4-EBA-on1027171741 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:28:14Z |
| institution | BVB |
| isbn | 9788793609587 8793609582 9781003339823 1003339824 9781000792782 1000792781 9781000795943 1000795942 |
| language | English |
| oclc_num | 1027171741 |
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| physical | 1 online resource |
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| publishDate | 2018 |
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| publisher | River Publishers, |
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| series | River Publishers series in biomedical engineering. |
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| spelling | Goede, Simon Lucas, author. Thyroid systems engineering : a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / Simon Lucas Goede, Melvin Khee-Shing Leow. Gistrup, Denmark : River Publishers, [2018] 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier River Publishers Series in Biomedical Engineering Print version record. Front Cover; Half Title Page; RIVER PUBLISHERS SERIES IN BIOMEDICALENGINEERING; Title Page -- Thyroid Systems EngineeringA Primer in Mathematical Modeling of theHypothalamus-Pituitary-Thyroid Axis; Copyright Page; DEDICATION; Contents; Preface; Acknowledgements; List of Figures; List of Tables; List of Abbreviations; Chapter 1 -- General Introduction; 1.1 Introduction; Chapter 2 -- Physiology of the HPT Axis; 2.1 Synopsis of Thyroid Biochemistry and Molecular; 2.2 Operation of the Hypothalamusâ#x80;#x93;Pituitary (HP); 2.3 Thyroid Physiology; 2.4 Physiological Feedback Representation of the HPT. ReferencesChapter 3-Modeling Principles; 3.1 Introduction; 3.2 Modeling Examples; 3.2.1 Modeling Example 1; 3.3 Electrical Network Representation of the Leaking Water Container; 3.4 Static Modeling; 3.5 Modeling Examples from Solid-state Physics and Electronic Engineering; 3.6 General Appearance and Decay Model with Electrical Network Elements; 3.7 Appearance Time Constant; 3.8 Determining the Value of the Appearance Time Constant; 3.9 Discussion; 3.10 Conclusion; References; Chapter 4-Medical Statistics and Mathematical Modeling Make Strange Bedfellows; 4.1 Introduction. 4.2 Pitfalls in the Application of Inferential Statistical Methods4.2.1 Explanation of the Observed Log-linear Relationship between [TSH] and [FT4]; 4.3 Abuse of Mathematical Models; 4.3.1 Critical Notes; 4.4 Future Developments; 4.5 Conclusion; References; Chapter 5 -- Systems Theory Applied on the Modeling of the HPT Axis and First Principles of Feedback and Homeostasis; 5.1 Introduction; 5.2 Definition of System Components; 5.3 System Dynamics; 5.4 Frequency Response of the First-order Low-pass Section; 5.5 Cascading System Blocks; 5.6 Example of a Feedback System. 5.6.1 Feed Forward Compensation5.7 Discussion; References; Chapter 6 -- The Mathematical Relationship between [FT4] and [TSH]; 6.1 Introduction; 6.1.1 History; 6.2 Linear-logarithmic Relationship between [FT4] and [TSH]; 6.3 Modeling the Curved [FT4]â#x80;#x93;[TSH] Characteristic; 6.4 Properties of the Exponential Function; 6.4.1 Effect of the Multiplier Model Parameter S; 6.4.2 Effect of the Exponential Model Parameter '; 6.5 Dynamic Signal Transfer of the HP Characteristic; 6.6 Generalized Expression of the HP Characteristic; 6.7 Discussion; References. Chapter 7 -- The Thyroid Gland and the Relationship Between [TSH] and [FT4]7.1 Introduction; 7.2 Model of the Thyroid Gland; 7.3 Discussion; References; Chapter 8 -- The Hypothalamusâ#x80;#x93;Pituitary (HPT) Set Point Theory; 8.1 Introduction; 8.2 The Hypothalamusâ#x80;#x93;Pituitary (HP) Control System; 8.3 Derivation of the Point of Maximum Curvature from the HP Function; 8.4 Theory Behind of the Physiology of the Homeostatic Control Process; 8.5 Point of Maximum Curvature of the Thyroid Characteristic; 8.6 Discussion; References; Chapter 9 -- The Human Hypothalamusâ#x80;#x93;Pituitaryâ#x80;#x93;Thyroid Control System. 9.1 Introduction. Targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology. Through a combination of formal mathematical reasoning and knowledge of the nature of thyroid physiology and supported by in-depth patient observations, this volume hones in on finding optimal treatment for people suffering from thyroid hormone disorders. At the same time, the editors--respectively an electrical engineer and a clinical thyroidoloist--introduce a new discipline aptly designated as Thyroid Systems Engineering. Readers will discover that mathematics can indeed model the behavior of the hypothalamus-pituitary-thyroid (HPT) axis. Focused on modeling, each of the eighteen chapters gives the reader a notion of the application of relevant mathematics to pertinent issues encountered in mainstream thyroidology. Many cellular processes resemble the flux of variables and states in a complex multi-parameter space through time analogous to current flow in electrical networks. It is then logical to apply the principles and physical laws of electrodynamics, electrical network theory, control systems theory and signal theory to many of the biological phenomena encountered in endocrinology. Such an approach is used liberally throughout the book and successfully yields elegant solutions to a number of models presented within. This book can serve as a reference to mathematical modeling in other aspects of endocrine physiology, and as the starting point for a fundamental course in medical modeling. It will appeal to postgraduates in electrical engineering, academic physicians and biomedical researchers. Further, readers equipped with advanced calculus, electrical network theory, control theory and signal theory should be able to follow the mathematical expositions that describe thyrotropic control. These expositions represent a new discipline based on mathematical modeling in physiology which is applicable to medical diagnostics, measurement, and treatment, allowing clinical teams to realize an optimized treatment for patients. Simon Goede, Melvin Khee-Shing Leow Thyroid gland Physiology Mathematical models. Thyroid gland. http://id.loc.gov/authorities/subjects/sh85135163 Mathematical models. http://id.loc.gov/authorities/subjects/sh85082124 Thyroid Gland https://id.nlm.nih.gov/mesh/D013961 Models, Theoretical https://id.nlm.nih.gov/mesh/D008962 Thyroïde Physiologie Modèles mathématiques. Thyroïde. Modèles mathématiques. mathematical models. aat SCIENCE Energy. bisacsh Physiology Mathematical models fast Leow, Melvin Khee-Shing, author. has work: Thyroid systems engineering (Text) https://id.oclc.org/worldcat/entity/E39PCYdRWtPYhbxt9RKtrYyVBX https://id.oclc.org/worldcat/ontology/hasWork Print version: Goede, Simon Lucas. Thyroid systems engineering. Gistrup, Denmark : River Publishers, [2018] 9788793609594 (OCoLC)1015856715 River Publishers series in biomedical engineering. FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1844096 Volltext |
| spellingShingle | Goede, Simon Lucas Leow, Melvin Khee-Shing Thyroid systems engineering : a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / River Publishers series in biomedical engineering. Front Cover; Half Title Page; RIVER PUBLISHERS SERIES IN BIOMEDICALENGINEERING; Title Page -- Thyroid Systems EngineeringA Primer in Mathematical Modeling of theHypothalamus-Pituitary-Thyroid Axis; Copyright Page; DEDICATION; Contents; Preface; Acknowledgements; List of Figures; List of Tables; List of Abbreviations; Chapter 1 -- General Introduction; 1.1 Introduction; Chapter 2 -- Physiology of the HPT Axis; 2.1 Synopsis of Thyroid Biochemistry and Molecular; 2.2 Operation of the Hypothalamusâ#x80;#x93;Pituitary (HP); 2.3 Thyroid Physiology; 2.4 Physiological Feedback Representation of the HPT. 4.2 Pitfalls in the Application of Inferential Statistical Methods4.2.1 Explanation of the Observed Log-linear Relationship between [TSH] and [FT4]; 4.3 Abuse of Mathematical Models; 4.3.1 Critical Notes; 4.4 Future Developments; 4.5 Conclusion; References; Chapter 5 -- Systems Theory Applied on the Modeling of the HPT Axis and First Principles of Feedback and Homeostasis; 5.1 Introduction; 5.2 Definition of System Components; 5.3 System Dynamics; 5.4 Frequency Response of the First-order Low-pass Section; 5.5 Cascading System Blocks; 5.6 Example of a Feedback System. 5.6.1 Feed Forward Compensation5.7 Discussion; References; Chapter 6 -- The Mathematical Relationship between [FT4] and [TSH]; 6.1 Introduction; 6.1.1 History; 6.2 Linear-logarithmic Relationship between [FT4] and [TSH]; 6.3 Modeling the Curved [FT4]â#x80;#x93;[TSH] Characteristic; 6.4 Properties of the Exponential Function; 6.4.1 Effect of the Multiplier Model Parameter S; 6.4.2 Effect of the Exponential Model Parameter '; 6.5 Dynamic Signal Transfer of the HP Characteristic; 6.6 Generalized Expression of the HP Characteristic; 6.7 Discussion; References. Chapter 7 -- The Thyroid Gland and the Relationship Between [TSH] and [FT4]7.1 Introduction; 7.2 Model of the Thyroid Gland; 7.3 Discussion; References; Chapter 8 -- The Hypothalamusâ#x80;#x93;Pituitary (HPT) Set Point Theory; 8.1 Introduction; 8.2 The Hypothalamusâ#x80;#x93;Pituitary (HP) Control System; 8.3 Derivation of the Point of Maximum Curvature from the HP Function; 8.4 Theory Behind of the Physiology of the Homeostatic Control Process; 8.5 Point of Maximum Curvature of the Thyroid Characteristic; 8.6 Discussion; References; Chapter 9 -- The Human Hypothalamusâ#x80;#x93;Pituitaryâ#x80;#x93;Thyroid Control System. Thyroid gland Physiology Mathematical models. Thyroid gland. http://id.loc.gov/authorities/subjects/sh85135163 Mathematical models. http://id.loc.gov/authorities/subjects/sh85082124 Thyroid Gland https://id.nlm.nih.gov/mesh/D013961 Models, Theoretical https://id.nlm.nih.gov/mesh/D008962 Thyroïde Physiologie Modèles mathématiques. Thyroïde. Modèles mathématiques. mathematical models. aat SCIENCE Energy. bisacsh Physiology Mathematical models fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85135163 http://id.loc.gov/authorities/subjects/sh85082124 https://id.nlm.nih.gov/mesh/D013961 https://id.nlm.nih.gov/mesh/D008962 |
| title | Thyroid systems engineering : a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / |
| title_auth | Thyroid systems engineering : a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / |
| title_exact_search | Thyroid systems engineering : a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / |
| title_full | Thyroid systems engineering : a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / Simon Lucas Goede, Melvin Khee-Shing Leow. |
| title_fullStr | Thyroid systems engineering : a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / Simon Lucas Goede, Melvin Khee-Shing Leow. |
| title_full_unstemmed | Thyroid systems engineering : a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / Simon Lucas Goede, Melvin Khee-Shing Leow. |
| title_short | Thyroid systems engineering : |
| title_sort | thyroid systems engineering a primer in mathematical modeling of the hypothalamus pituitary thyroid axis |
| title_sub | a primer in mathematical modeling of the hypothalamus-pituitary-thyroid axis / |
| topic | Thyroid gland Physiology Mathematical models. Thyroid gland. http://id.loc.gov/authorities/subjects/sh85135163 Mathematical models. http://id.loc.gov/authorities/subjects/sh85082124 Thyroid Gland https://id.nlm.nih.gov/mesh/D013961 Models, Theoretical https://id.nlm.nih.gov/mesh/D008962 Thyroïde Physiologie Modèles mathématiques. Thyroïde. Modèles mathématiques. mathematical models. aat SCIENCE Energy. bisacsh Physiology Mathematical models fast |
| topic_facet | Thyroid gland Physiology Mathematical models. Thyroid gland. Mathematical models. Thyroid Gland Models, Theoretical Thyroïde Physiologie Modèles mathématiques. Thyroïde. Modèles mathématiques. mathematical models. SCIENCE Energy. Physiology Mathematical models |
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