Disulfiram and its metabolite, diethyldithiocarbamate: pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London u.a.
Chapman & Hall
1992
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| Ausgabe: | 1. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 452 S. |
| ISBN: | 0412360101 |
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| adam_text |
DISULFIRAM AND ITS METABOLITE, DIETHYLDITHIOCARBAMATE PHARMACOLOGY AND
STATUS IN THE TREATMENT OF ALCOHOLISM, HIV? INFECTIONS, AIDS AND HEAVY
METAL TOXIE'ITY PETER K. GESSNER PROFESSOR OF PHARMACOLOGY AND
THERAPEUTICS SCHOOL OF MEDICINE AND BIOMEDICAL SCIENCES STATE UNIVERSITY
OF NEW YORK AT BUFFALO BUFFALO, NEW YORK TERESA GESSNER RESEARCH
PROFESSOR OF PHARMACOLOGY ROSWELL PARK GRADUATE DIVISION STATE
UNIVERSITY OF NEW YORK AT BUFFALO ROSWELL PARK CANCER INSTITUTE BUFFALO,
NEW YORK CHAPMAN & HALL LONDON * GLASGOW * NEW YORK * TOKYO * MELBOURNE
* MADRAS CONTENTS FIGURE ACKNOWLEDGEMENTS XI PREFACE XIIL GLOSSARY . XV
1 INTRODUCTION AND SCOPE OF MONOGRAPH 1 1.1 INTRODUCTION 1 1.2 SCOPE OF
MONOGRAPH 3 1.3 EARLIER REVIEWS 5 2 RELEVANT PHYSICAL AND CHEMICAL
PROPERTIES 7 2.1 INTRODUCTION AND GENERAL PROPERTIES 7 2.2
ACID-CATALYZED DECOMPOSITION 8 2.3 FORMATION OF METAL COMPLEXES 9 3
REACTIONS OF DISULFIRAM AND DIETHYLDITHIO- CARBAMATE WITH BLOOD
CONSTITUENTS 13 3.1 INTRODUCTION 13 3.2 FORMATION OF COPPER COMPLEXES 14
3.3 FORMATION OF MIXED DISULFIDES 15 3.4 UPTAKE OF DISULFIRAM BY BLOOD
CELLS 17 35 SUMMARY 19 4 ASSAY METHODS FOR DISULFIRAM AND METABOLITES IN
BIOLOGICAL MATERIALS 21 4.1 INTRODUCTION 21 4.2 GENERAL CONSIDERATIONS
22 4.3 SPECIFIC METHODS 25 4.4 OTHER METHODS 26 VI CONTENTS 5 METABOLISM
OF DISULFIRAM AND DIETHYLDITHIO- CARBAMATE 29 51 INTRODUCTION 29 5.2
FORMATION OF MIXED DISULFIDES WITH GENERATION OF DIETHYLDITHIOCARBAMATE
30 5.3 FORMATION OF DISULNRAM FROM DIETHYLDITHIOCARBAMATE 32 5.4
FORMATION OF THE COPPER COMPLEX 34 5.5 5-GLUCURONIDE OF
DIETHYLDITHIOCARBAMIC ACID 34 5.6 FORMATION OF CARBON DISULFIDE AND
DIETHYLAMINE 36 5.7 METABOLISM OF CARBON DISULFIDE AND FORMATION OF
CARBONYL SULFIDE 37 5.8 THE METHYL ESTER OF DIETHYLDITHIOCARBAMIC ACID
38 5.9 THE METHYL ESTER OF DIETHYLMONOTHIOCARBAMIC ACID 40 5.10 OTHER
METABOLITES 41 6 PHARMACOKINETIC ASPECTS OF THE DISPOSITION OF
DISULFIRAM AND METABOLITES 43 6.1 INTRODUCTION 44 6.2 METHODS 44 6.3
URINARY EXCRETION OF DISULFIRAM METABOLITES 51 6.4 PULMONARY EXCRETION
OF DISULFIRAM METABOLITES 54 6.5 PLASMA DISULFIRAM AND METABOLITES
FOLLOWING ITS ADMINISTRATION 56 6.6 DIETHYLDITHIOCARBAMATE AND
METABOLITES FOLLOWING ITS ADMINISTRATION 60 7 HEAVY METALS: EFFECTS OF
DIETHYLDITHIOCARBAMATE AND DISULFIRAM ADMINISTRATION 65 65 69 \ 71 73 79
81 85 88 90 93 8 DISULFIRAM AND DIETHYLDITHIOCARBAMATE AS ENZYME
INHIBITORS 95 8.1 INTRODUCTION 96 8.2 INHIBITION OF DRUG METABOLIZING
ENZYMES 102 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 7.10 INTRODUCTION
THALLIUM ZINC CADMIUM LEAD NICKEL COPPER MERCURY PLATINUM POLONIUM
CONTENTS VII 8.3 INHIBITION OF DOPAMINE JS-HYDROXYLASE 120 8.4
INHIBITION OF SUPEROXIDE DISMUTASE 126 8.5 INACTIVATION OF GLUTATHIONE
PEROXIDASE 133 8.6 EFFECT OF CATALASE 135 9 INHIBITION OF ALDEHYDE
DEHYDROGENASE 137 9.1 INTRODUCTION 137 92 PHENOMENOLOGY OF THE
INHIBITION BY DISULFIRAM 145 93 MECHANISM OF THE INHIBITION 150 94 ROLE
OF DISULFIRAM METABOLITES 154 9-5 INHIBITION OF ALDEHYDE DEHYDROGENASES
IN BLOOD 158 9.6 INHIBITION OF METABOLISM OF ENDOGENOUS ALDEHYDES 162 97
ALDEHYDE AND XANTHINE OXIDASES 166 10 THE DISULFIRAM-ETHANOL REACTION
167 10.1 INTRODUCTION 167 10.2 DISCOVERY AND THERAPEUTIC APPLICATION 168
10.3 PHARMACOLOGICAL CHARACTERISTICS 171 10.4 BLOOD ACETALDEHYDE
DETERMINATION 177 10.5 THE ACETALDEHYDE HYPOTHESIS 178 10.6 QUEST FOR
ANIMAL MODELS OF THE REACTION 184 10.7 EFFECT OF DISULFIRAM ON ETHANOL
METABOLISM 191 10.8 THE DOPAMINE /MIYDROXYLASE HYPOTHESIS 193 10.9
EFFECT OF ETHANOL IN ANIMALS PRETREATED WITH DISULFIRAM METABOLITES 199
10.10 TREATMENT OF THE DISULFIRAM-ETHANOL REACTION 201 11 DISULFIRAM
THERAPY OF ALCOHOL ABUSE 205 11.1 INTRODUCTION 205 11.2 GOALS OF
DISULFIRAM THERAPY 209 11.3 DISULFIRAM TREATMENT COMPONENTS CORRELATED
WITH REDUCTION OF DRINKING DAYS 209 11.4 DISULFIRAM THERAPY PARADIGMS
214 11.5 ELECTION OF AND CONTINUATION IN TREATMENT 223 11.6
CHARACTERISTICS OF DISULFIRAM'S THERAPEUTIC EFFECTS 224 11.7 SIDE
EFFECTS OF DISULFIRAM THERAPY 232 11.8 CHEMICAL COMPLIANCE MONITORING
244 11.9 DISULFIRAM IMPLANTS 245 12 IMMUNOMODULATORY EFFECTS OF
DIETHYLDITHIOCARBAMATE 247 12.1 INTRODUCTION 248 12.2 STIMULATION OF
ANTIBODY RESPONSE TO SHEEP RED BLOOD CELLS 249 VIII CONTENTS 12.3
ENHANCEMENT OF MITOGEN-INDUCED LYMPHOPROLIFERATION 251 12.4 EFFECT ON
LYMPHOPROLIFERATIVE RESPONSE TO ALLOANTIGENS 255 12.5 INTERACTION WITH
ASYMMETRICAL NEOCORTICAL LESIONS 256 12.6 EFFECTS ON CELL-MEDIATED
CYTOTOXICITY 257 12.7 EFFECT ON DELAYED-TYPE HYPERSENSITIVITY REACTION
261 12.8 INDUCTION OF T-CELL DIFFERENTIATION 261 12.9 EFFECT ON
LYMPHOCYTE POPULATIONS IN VIVO 267 12.10 EFFECTS ON MONONUCLEAR
PHAGOCYTIC CELLS 272 12.11 EXPERIMENTAL THERAPEUTICS 273 12.12
IMMUNOMODULATORY EFFECTS OF RELATED COMPOUNDS 275 12.13 CONCLUSIONS 275
13 CLINICAL STATUS OF DIETHYLDITHIOCARBAMATE AS AN IMMUNOSTIMULANT 279
13.1 INTRODUCTION 279 132 IN THE TREATMENT OF HIV INFECTIONS AND AIDS
280 13-3 IN GASTROINTESTINAL SURGERY PATIENTS 290 13.4 AS A THERAPEUTIC
AGENT IN AUTOIMMUNE DISEASE 290 135 IN PATIENTS WITH NEOPLASTIC DISEASE
291 136 AS AN ADJUVANT FOR INFLUENZA VACCINATION 292 13.7 SUMMARY 292 14
MODULATION OF VARIOUS BIOLOGICAL PHENOMENA 295 14.1 CYTOTOXICITY 295
14.2 MODULATION OF THE EFFECTS OF OXIDATIVE STRESS 301 14.3 MODULATION
OF THE EFFECTS OF RADIATION AND HYPERTHERMIA 306 15 MODULATION OF CANCER
CHEMOTHERAPY 313 15.1 INTRODUCTION 313 15.2 PRECLINICAL STUDIES 315 15.3
CLINICAL STUDIES 328 15.4 CONCLUSIONS 334 16 TOXICOLOGY 335 16.1
INTRODUCTION 335 16.2 ACUTE TOXICITY 336 16.3 CHRONIC TOXICITY 341 16.4
EFFECTS ON LIVER 342 16.5 TESTING FOR MUTAGENICITY 343 16.6 TESTING FOR
CARCINOGENICITY 344 16.7 TESTING FOR TERATOGENIC AND REPRODUCTIVE
TOXICITY 345 CONTENTS IX APPENDIX - THE ROAD TO ANATABUSE - PROFESSOR
ERICK JACOBSEN 347 REFERENCES 353 AUTHOR AND CITATION INDEX 413 SUBJECT
INDEX |
| any_adam_object | 1 |
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| classification_rvk | XI 3300 |
| ctrlnum | (OCoLC)23766908 (DE-599)BVBBV006064293 |
| dewey-full | 616.86/1061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.86/1061 |
| dewey-search | 616.86/1061 |
| dewey-sort | 3616.86 41061 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1. ed. |
| format | Book |
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| id | DE-604.BV006064293 |
| illustrated | Not Illustrated |
| indexdate | 2024-09-23T12:06:07Z |
| institution | BVB |
| isbn | 0412360101 |
| language | English |
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| publisher | Chapman & Hall |
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| spelling | Gessner, Peter K. Verfasser aut Disulfiram and its metabolite, diethyldithiocarbamate pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity Peter K. Gessner ; Teresa Gessner 1. ed. London u.a. Chapman & Hall 1992 XIX, 452 S. txt rdacontent n rdamedia nc rdacarrier Diethyldithiocarbamate Physiological effect Diethyldithiocarbamate Therapeutic use Testing Disulfiram Physiological effect Disulfiram therapeutic use Ditiocarb therapeutic use Drug Evaluation Disulfiram (DE-588)4306227-1 gnd rswk-swf Diethyldithiocarbamate (DE-588)4309452-1 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Diethyldithiocarbamate (DE-588)4309452-1 s Pharmakologie (DE-588)4045687-0 s DE-604 Disulfiram (DE-588)4306227-1 s Gessner, Teresa Verfasser aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=003824591&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gessner, Peter K. Gessner, Teresa Disulfiram and its metabolite, diethyldithiocarbamate pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity Diethyldithiocarbamate Physiological effect Diethyldithiocarbamate Therapeutic use Testing Disulfiram Physiological effect Disulfiram therapeutic use Ditiocarb therapeutic use Drug Evaluation Disulfiram (DE-588)4306227-1 gnd Diethyldithiocarbamate (DE-588)4309452-1 gnd Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4306227-1 (DE-588)4309452-1 (DE-588)4045687-0 |
| title | Disulfiram and its metabolite, diethyldithiocarbamate pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity |
| title_auth | Disulfiram and its metabolite, diethyldithiocarbamate pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity |
| title_exact_search | Disulfiram and its metabolite, diethyldithiocarbamate pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity |
| title_full | Disulfiram and its metabolite, diethyldithiocarbamate pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity Peter K. Gessner ; Teresa Gessner |
| title_fullStr | Disulfiram and its metabolite, diethyldithiocarbamate pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity Peter K. Gessner ; Teresa Gessner |
| title_full_unstemmed | Disulfiram and its metabolite, diethyldithiocarbamate pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity Peter K. Gessner ; Teresa Gessner |
| title_short | Disulfiram and its metabolite, diethyldithiocarbamate |
| title_sort | disulfiram and its metabolite diethyldithiocarbamate pharmacology and status in the treatment of alcoholism hiv infections aids and heavy metal toxicity |
| title_sub | pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity |
| topic | Diethyldithiocarbamate Physiological effect Diethyldithiocarbamate Therapeutic use Testing Disulfiram Physiological effect Disulfiram therapeutic use Ditiocarb therapeutic use Drug Evaluation Disulfiram (DE-588)4306227-1 gnd Diethyldithiocarbamate (DE-588)4309452-1 gnd Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Diethyldithiocarbamate Physiological effect Diethyldithiocarbamate Therapeutic use Testing Disulfiram Physiological effect Disulfiram therapeutic use Ditiocarb therapeutic use Drug Evaluation Disulfiram Diethyldithiocarbamate Pharmakologie |
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