Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | Volltext Inhaltsverzeichnis |
| Item Description: | Zsfassung in dt. und engl. Sprache |
| Physical Description: | IX, 117, XXVII S. Ill., graph. Darst. |
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| 100 | 1 | |a Dwertmann, Anne |d 1983- |e Verfasser |0 (DE-588)1026926904 |4 aut | |
| 245 | 1 | 0 | |a Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 |c von Anne Dwertmann |
| 246 | 1 | 3 | |a Wirkung des Tumorsuppressors Arf auf Miz1 und Sumoylierung von Myc und Miz1 |
| 264 | 1 | |c 2012 | |
| 300 | |a IX, 117, XXVII S. |b Ill., graph. Darst. | ||
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| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Zsfassung in dt. und engl. Sprache | ||
| 502 | |a Würzburg, Univ., Diss., 2012 | ||
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENTS
LIST O F FIGURES VII
LIST O F TABLES IX
1. INTRODUCTION 1
1.1. SUMOYLATION 2
1.2. THE TRANSCRIPTION FACTOR MIZL 10
1.3. THE ONCOGENIC TRANSCRIPTION FACTOR MYC 14
1.4. OBJECTIVES OF THE THESIS 20
2. MATERIALS 2 1
2.1. STRAINS AND CELL LINES 21
2.2. CULTIVATION MEDIA AND SUPPLEMENTS 22
2.3. NUCLEIC ACIDS 23
2.4. PLASMIDS 26
2.5. ANTIBODIES 28
2.6. CHEMICALS 29
2.7. ENZYMES, STANDARDS AND KITS 29
2.8. BUFFERS AND SOLUTIONS 30
2.9. CONSUMABLES AND EQUIPMENT 36
2.10. SOFTWARE 38
3. M E T H O D S 4 1
3.1. MOLECULAR BIOLOGY METHODS 41
3.2. CELL BIOLOGY METHODS 48
3.3. PROTEIN BIOCHEMISTRY METHODS 52
4. RESULTS 5 9
4.1. THE TUMOR SUPPRESSOR ARF INTERACTS WITH MIZL TO ANTAGONIZE ITS
FUNCTION . 59
4.2. SUMOYLATION OF MIZL 70
4.3. SUMOYLATION OF MYC 85
V
HTTP://D-NB.INFO/1026927064
IMAGE 2
5. DISCUSSION 9 9
5.1. ARF INHIBITS MIZL FUNCTION BY INDUCING A REPRESSIVE MYC/MIZL
COMPLEX . . 99
5.2. MIZL CAN BE SUMOYLATED AT A SPECIFIC LYSINE WHICH IS INDUCED BY ARF
. . . . 109
5.3. MYC GETS SUMOYLATED AT MANY DIFFERENT SITES 115
BIBLIOGRAPHY I
A. LIST O F ABBREVIATIONS XXIII
A.L. PREFIXES XXIII
A.2. UNITS XXIII
A.3. PROTEINS, PROTEIN DOMAINS AND OTHER BIOMOLECULES XXIV
A.4. CHEMICALS AND SOLUTIONS XXV
A.5. OTHER ABBREVIATIONS XXVI
B. A C K N O W L E D G E M E N T S XXIX
C. CURRICULUM V I T A E XXXI
D. AFFIDAVIT XXXIII
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| dewey-full | 571.936 |
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| dewey-ones | 571 - Physiology & related subjects |
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| discipline | Biologie |
| format | Thesis Book |
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| spelling | Dwertmann, Anne 1983- Verfasser (DE-588)1026926904 aut Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 von Anne Dwertmann Wirkung des Tumorsuppressors Arf auf Miz1 und Sumoylierung von Myc und Miz1 2012 IX, 117, XXVII S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dt. und engl. Sprache Würzburg, Univ., Diss., 2012 Myc (DE-588)4267356-2 gnd rswk-swf Repression Genetik (DE-588)4334286-3 gnd rswk-swf Apoptosis (DE-588)4291096-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Apoptosis (DE-588)4291096-1 s Myc (DE-588)4267356-2 s Repression Genetik (DE-588)4334286-3 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-71876 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-71876 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025352826&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dwertmann, Anne 1983- Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 Myc (DE-588)4267356-2 gnd Repression Genetik (DE-588)4334286-3 gnd Apoptosis (DE-588)4291096-1 gnd |
| subject_GND | (DE-588)4267356-2 (DE-588)4334286-3 (DE-588)4291096-1 (DE-588)4113937-9 |
| title | Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 |
| title_alt | Wirkung des Tumorsuppressors Arf auf Miz1 und Sumoylierung von Myc und Miz1 |
| title_auth | Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 |
| title_exact_search | Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 |
| title_full | Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 von Anne Dwertmann |
| title_fullStr | Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 von Anne Dwertmann |
| title_full_unstemmed | Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 von Anne Dwertmann |
| title_short | Impact of the Tumor Suppressor Arf on Miz1 and Sumoylation of Myc and Miz1 |
| title_sort | impact of the tumor suppressor arf on miz1 and sumoylation of myc and miz1 |
| topic | Myc (DE-588)4267356-2 gnd Repression Genetik (DE-588)4334286-3 gnd Apoptosis (DE-588)4291096-1 gnd |
| topic_facet | Myc Repression Genetik Apoptosis Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-71876 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025352826&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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