HIV and membrane receptors:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1997
|
| Schriftenreihe: | Medical intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 190 S. Ill., graph. Darst. |
| ISBN: | 3540631275 1570594643 |
Internformat
MARC
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| 245 | 1 | 0 | |a HIV and membrane receptors |c Dimiter S. Dimitrov ; Christopher C. Broder |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1997 | |
| 300 | |a 190 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 700 | 1 | |a Broder, Christopher C. |d 1961- |e Verfasser |0 (DE-588)11570227X |4 aut | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007805351&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1804126116853579776 |
|---|---|
| adam_text | i, CONTENTS =jj
1. Virus Evolution and Structure 1
Evolution of Viruses 1
Nonenveloped Viruses 4
Envelope Proteins 5
Conclusions 12
2. Receptors and Virus Infections 15
Membrane Receptors 15
Virus Receptors 16
Receptor Virus Interactions 17
Virus Entry 19
Receptors and Tropism 21
Receptors and Pathogenesis 22
Prevention of Virus Receptor Interactions 23
Conclusions 24
3. HIV 27
Origin and Evolution of HIV 28
Virion Composition and Structure 31
HIV Life Cycle 34
Infection Kinetics and Pathogenesis 37
Prevention and Treatment of HIV Infections 41
Conclusions 42
4. The HIV Envelope Glycoprotein 45
Envelope Glycoprotein Biosynthesis 45
Primary Sequence and Variation 46
Secondary Structure Elements 47
Models of Three Dimensional Structure 51
Oligomeric Stucture 55
Conclusions 56
5. HIV Receptors 61
CD4 Structure 61
Biological Function of CD4 65
CD4 Interactions with the HIV Envelope Glycoprotein 68
Alternative Receptors 70
Conclusions 74
6. The Fusion Cofactors/Coreceptors 79
Evidence for the Existence of Fusion/Entry Cofactors 79
Properties of the Fusion/Entry Cofactors 85
Candidate Fusion Cofactors 90
Conclusions 92
7. The HIV 1 Coreceptors: Identification, Biological Function
and Structure 99
The Discovery of CXCR4 as an HIV 1 Cofactor 99
Inhibition of HIV 1 Entry by Chemokines 104
Chemokine Receptor Utilization by Primary
HIV 1 Isolates: Identification of CCR5, CCR2B
and CCR3 as Cofactors for HIV 1 106
The Chemokine Receptors 109
HIV 1 Coreceptor Structure 115
Fusion Cofactors and Other Immunodeficiency Viruses 117
Conclusions 118
8. Receptor Mediated HIV Entry 125
Attachment of HIV to Cell Surfaces 125
Membrane Fusion 129
A Model of Receptor Mediated Entry 139
Conclusions 141
9. HIV 1 Tropism and Pathogenesis 149
Cell Tropism and CD4 149
Tropism to Macrophages and T Cell Lines 150
Coreceptors and Tropism 152
CD4 and Pathogenesis 156
Coreceptors and Pathogenesis 159
HIV Evolution, Receptors and Coreceptors 162
Conclusions 162
10. Biomedical Implications 169
Lessons from Antiviral Agents Targeting Entry 169
Coreceptors as Targets for HIV Inhibition 178
Vaccine Development and Coreceptors 180
Implications for Development of New Drug
and Gene Delivery Systems 181
Conclusions 182
Index 189
|
| any_adam_object | 1 |
| author | Dimitrov, Dimiter S. 1954- Broder, Christopher C. 1961- |
| author_GND | (DE-588)115702261 (DE-588)11570227X |
| author_facet | Dimitrov, Dimiter S. 1954- Broder, Christopher C. 1961- |
| author_role | aut aut |
| author_sort | Dimitrov, Dimiter S. 1954- |
| author_variant | d s d ds dsd c c b cc ccb |
| building | Verbundindex |
| bvnumber | BV011588748 |
| ctrlnum | (OCoLC)260043691 (DE-599)BVBBV011588748 |
| format | Book |
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| id | DE-604.BV011588748 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:12:21Z |
| institution | BVB |
| isbn | 3540631275 1570594643 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007805351 |
| oclc_num | 260043691 |
| open_access_boolean | |
| owner | DE-29 DE-12 |
| owner_facet | DE-29 DE-12 |
| physical | 190 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Medical intelligence unit |
| spelling | Dimitrov, Dimiter S. 1954- Verfasser (DE-588)115702261 aut HIV and membrane receptors Dimiter S. Dimitrov ; Christopher C. Broder New York [u.a.] Springer [u.a.] 1997 190 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical intelligence unit Literaturangaben Zellrezeptor (DE-588)4133853-4 gnd rswk-swf HIV (DE-588)4200792-6 gnd rswk-swf Membranfusion (DE-588)4210049-5 gnd rswk-swf Transfektion (DE-588)4185874-8 gnd rswk-swf Hüllproteine (DE-588)4273116-1 gnd rswk-swf Membranrezeptor (DE-588)4136267-6 gnd rswk-swf Virusrezeptor (DE-588)4348801-8 gnd rswk-swf HIV (DE-588)4200792-6 s Membranrezeptor (DE-588)4136267-6 s DE-604 Hüllproteine (DE-588)4273116-1 s Zellrezeptor (DE-588)4133853-4 s Membranfusion (DE-588)4210049-5 s Virusrezeptor (DE-588)4348801-8 s Transfektion (DE-588)4185874-8 s Broder, Christopher C. 1961- Verfasser (DE-588)11570227X aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007805351&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dimitrov, Dimiter S. 1954- Broder, Christopher C. 1961- HIV and membrane receptors Zellrezeptor (DE-588)4133853-4 gnd HIV (DE-588)4200792-6 gnd Membranfusion (DE-588)4210049-5 gnd Transfektion (DE-588)4185874-8 gnd Hüllproteine (DE-588)4273116-1 gnd Membranrezeptor (DE-588)4136267-6 gnd Virusrezeptor (DE-588)4348801-8 gnd |
| subject_GND | (DE-588)4133853-4 (DE-588)4200792-6 (DE-588)4210049-5 (DE-588)4185874-8 (DE-588)4273116-1 (DE-588)4136267-6 (DE-588)4348801-8 |
| title | HIV and membrane receptors |
| title_auth | HIV and membrane receptors |
| title_exact_search | HIV and membrane receptors |
| title_full | HIV and membrane receptors Dimiter S. Dimitrov ; Christopher C. Broder |
| title_fullStr | HIV and membrane receptors Dimiter S. Dimitrov ; Christopher C. Broder |
| title_full_unstemmed | HIV and membrane receptors Dimiter S. Dimitrov ; Christopher C. Broder |
| title_short | HIV and membrane receptors |
| title_sort | hiv and membrane receptors |
| topic | Zellrezeptor (DE-588)4133853-4 gnd HIV (DE-588)4200792-6 gnd Membranfusion (DE-588)4210049-5 gnd Transfektion (DE-588)4185874-8 gnd Hüllproteine (DE-588)4273116-1 gnd Membranrezeptor (DE-588)4136267-6 gnd Virusrezeptor (DE-588)4348801-8 gnd |
| topic_facet | Zellrezeptor HIV Membranfusion Transfektion Hüllproteine Membranrezeptor Virusrezeptor |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007805351&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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