Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Berlin, Humboldt-Univ., Diss., 2005 |
| Beschreibung: | 51 S. graph. Darst. 30 cm |
Internformat
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Datensatz im Suchindex
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| adam_text | 1 INTRODUCTION 4
1.1 Definition and classification 4
1.1.1 Gestational hypertension 4
1.1.2 Preeclampsia and eclampsia 5
1.1.3 Chronic hypertension 5
1.1.4 Preeclampsia superimposed on chronic hypertension 5
1.2 Clinical outcomes 5
1.3 blood pressure and cardiovascular adaptations in pregnancy 6
1.4 Summary of the pathogeneses of gestational hypertension and preeclampsia 7
1.4.1 Remodelling of the uterine spiral arteries and endothelial cell dysfunction 8
1.4.2 Immune malimplantation and regulation of maternal fetal tolerance 8
1.5 Tumor necrosis factor alpha (TNF a) 10
1.5.1 Summary of the roles of TNF a in inflammation and immunity 11
1.5.2 TNF a and pregnancy. 12
1.6 Genetic of TNF a 12
1.7 Objectives 15
2 MATERIALS AND METHODS 16
2.1 Materials 16
2.1.1 Buffer and solution 16
2.1.2 Reagents 17
2.1.3 Instruments 18
2.2 METHODS 19
2.2.1 Clinical subjects and data collection 19
2.2.2 Isolation ofgenomic DNAfrom whole blood. 20
2.2.3 PCR amplication 20
2.2.4 Restriction fragment length polymorphism (RFLP) analysis 21
2.2.5 Gel electrophoresis and visualization 22
2.3 Statistical analysis 22
3 RESULTS 23
3.1 maternal demographic data of the subjects 23
3.2 the distribution of the g/ a polymorphism of tnf a at position 308 in pregnant women 25
3.3 The associations between changes of maternal blood pressures and urinary protein
excretion during pregnancy and maternal genotypes of tnf a 26
3.4 the associations between changes of maternal blood pressures and urinary protein
excretion during pregnancy and tnf1 (g) / 2 (a) allele 29
4 DISCUSSION 32
4.1 CLINICAL MATERNAL CHARACTERISTICS OF THE SUBJECTS 32
4.2 THE G/A POLYMORPHISM OF TNF a PROMOTER REGION AT POSITION 308 33
4.3 The associations between changes of maternal blood pressures and urinary protein
EXCRETION DURING PREGNANCY AND MATERNAL GENOTYPES OF TNF a 33
4.4 The roles of TNF1 (G)/ 2 (A) allele in the alteration of maternal blood pressures and
URINARY PROTEIN EXCRETION DURING PREGNANCY 35
5 SUMMARY 38
6 ACKNOWLEDGEMENTS 40
7 REFERENCES 41
8 ABBREVIATIONS 48
9 CURRICULUM VITAE 49
10 MY PUBLICATION LIST 50
DECLARATION 51
3
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| any_adam_object | 1 |
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| bvnumber | BV019823988 |
| ctrlnum | (OCoLC)254947844 (DE-599)BVBBV019823988 |
| discipline | Medizin |
| format | Book |
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| indexdate | 2024-07-09T20:06:57Z |
| institution | BVB |
| language | English |
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| spelling | Chen, You-Peng 1966- Verfasser (DE-588)129832944 aut Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension von Chen You-Peng 2005 51 S. graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Berlin, Humboldt-Univ., Diss., 2005 (DE-588)4113937-9 Hochschulschrift gnd-content HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013149207&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chen, You-Peng 1966- Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension |
| subject_GND | (DE-588)4113937-9 |
| title | Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension |
| title_auth | Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension |
| title_exact_search | Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension |
| title_full | Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension von Chen You-Peng |
| title_fullStr | Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension von Chen You-Peng |
| title_full_unstemmed | Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension von Chen You-Peng |
| title_short | Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension |
| title_sort | impact of genetic variation of tumor necrosis factor alpha tnf a tnf alpha on gestational hypertension |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013149207&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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