Biology of oral cancer: key apoptotic regulators
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton ; London ; New York
CRC Press
2017
|
| Ausgabe: | First issued in paperback |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | xix, 272 Seiten Illustrationen |
| ISBN: | 9781138076761 1138076767 |
Internformat
MARC
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| 245 | 1 | 0 | |a Biology of oral cancer |b key apoptotic regulators |c Prakash S. Bisen, Zakir Khan, Saurabh Bundela |
| 246 | 1 | 3 | |a Oral cancer |
| 250 | |a First issued in paperback | ||
| 264 | 1 | |a Boca Raton ; London ; New York |b CRC Press |c 2017 | |
| 300 | |a xix, 272 Seiten |b Illustrationen | ||
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Datensatz im Suchindex
| _version_ | 1804177600037257216 |
|---|---|
| adam_text | Contents
Preface...................................................................xv
Acknowledgments..........................................................x i x
Chapter 1 Cancer: A Worldwide Menace.....................................1
Key Words.....................................................1
1Л Introduction.............................................1
1.2 History..................................................6
1.2.1 Theories.........................................6
1.2.1.1 Humoral Theory..........................7
1.2.1.2 Lymph Theory............................7
1.2.1.3 Blastema Theory.........................7
1.2.1.4 Chronic Irritation Theory...............7
1.2.1.5 Trauma Theory...........................7
1.2.1.6 Parasite Theory.........................7
1.2.2 Classification...................................8
1.2.2.1 Lymphoma and Leukemia...................8
1.2.2.2 Carcinoma..............................10
1.2.2.3 Sarcoma................................11
1.2.2.4 Blastoma...............................13
1.2.2.5 Germ Cell Tumor........................14
1.3 Selected Types of Cancers with Their Symptoms..........15
1.3.1 Breast Cancer...................................15
1.3.1.1 Signs and Symptoms.....................16
1.3.1.2 Risk Factors...........................16
1.3.1.3 Treatment..............................17
1.3.2 Skin Cancer.....................................18
1.3.2.1 Basal Cell Skin Cancer.................19
1.3.2.2 Squamous Cell Skin Cancer..............19
1.3.2.3 Melanoma...............................20
1.3.2.4 Signs and Symptoms.....................20
1.3.2.5 Risk Factors...........................20
1.3.2.6 Treatment..............................20
1.3.3 Oral and Pharynx Cancer.........................21
1.3.3.1 Signs and Symptoms.....................22
1.3.3.2 Risk Factors...........................22
1.3.3.3 Treatment..............................22
1.3.4 Lung and Bronchus Cancer........................22
1.3.4.1 Signs and Symptoms.....................23
1.3.4.2 Risk Factors...........................24
1.3.4.3 Treatment..............................25
VII
vili Contents
1.3.5 Colon and Rectum Cancer.........................26
1.3.5.1 Signs and Symptoms.....................27
1.3.5.2 Risk Factors...........................28
1.3.5.3 Treatment..............................28
1.3.6 Ovarian Cancer..................................29
1.3.6.1 Signs and Symptoms.....................30
1.3.6.2 Risk Factors...........................30
1.3.6.3 Treatment..............................31
1.3.7 Pancreatic Cancer...............................31
1.3.7.1 Types of Pancreatic Tumors.............32
1.3.7.2 Signs and Symptoms.....................33
1.3.7.3 Risk Factors...........................34
1.3.7.4 Treatment..............................34
1.3.8 Prostate Cancer.................................35
1.3.8.1 Signs and Symptoms.....................36
1.3.8.2 Risk Factors...........................37
1.3.8.3 Treatment..............................37
1.4 Major Causes behind Cancer.............................37
1.4.1 Genetical Causes................................37
1.4.2 Infection.......................................40
1.4.3 Ionizing Radiations.............................40
1.4.4 Chemicals.......................................41
1.5 Epidemiology...........................................42
1.6 Diagnosis and Pathology................................43
1.7 Conclusion.............................................46
References..................................................47
Chapter 2 Oral Cancer..................................................49
Key Words...................................................49
2.1 Introduction...........................................49
2.2 Epidemiology...........................................49
2.3 Signs and Symptoms.....................................50
2.4 Sex and Age Distribution...............................51
2.5 Etiology...............................................51
2.5.1 Tobacco and Alcohol Consumption.................51
2.5.2 Human Papillomavirus (HPV)......................52
2.5.3 Diet............................................52
2.5.4 Other Factors...................................53
2.6 Pathology..............................................53
2.6.1 Oral Premalignancy..............................53
2.6.2 Leukoplakia.....................................53
. 2.6.3 Dysplasia.......................................54
2.6.4 Erythroplakia...................................54
2.6.5 Lichen Planus...................................54
2.6.6 Oral Submucous Fibrosis (OSMF)..................54
Contents
IX
2.6.7 Oral Squamous Cell Carcinoma (OSCC).............54
2.7 Staging.................................................55
2.7.1 Molecular Basis of Oral Carcinogenesis..........57
2.7.2 Precancerous Lesions of the Oral Cavity.........58
2.7.3 Metastasis and Survival....................... 59
2.8 Individual Cancers of the Oral Cavity...................60
2.8.1 Lip Cancer......................................60
2.8.2 Alveolar and Retromolar Trigone Cancer..........61
2.8.3 Floor of Mouth Cancer...........................61
2.8.4 Buccal Mucosa Cancer............................61
2.8.5 Tongue Cancer...................................62
2.8.6 Hard Palate Cancer..............................62
2.9 Conclusion..............................................63
References....................................................64
Chapter 3 Proliferative and Apoptotic Signaling in Oral Cancer..........71
Key Words.....................................................71
3.1 Introduction............................................71
3.2 Regulation of Cell Homeostasis..........................72
3.3 Somatic Gene Mutation...................................73
3.4 Oncogenes and Tumor Suppressors.........................74
3.4.1 Ras Gene Family Signaling Pathways..............74
3.4.2 c-Myc, Growth, and Apoptotic Signaling..........78
3.4.3 Oncogene Activation.............................82
3.4.3.1 Chromosomal Rearrangements.............82
3.4.3.2 Mutations..............................83
3.4.3.3 Gene Amplification.....................83
3.4.4 p53, pRb, and E2F Signaling.....................83
3.4.5 Bel-2 and Bax...................................86
3.5 NF-кВ...................................................88
3.6 Serine/Threonine Kinases................................88
3.7 Steroid Hormones........................................88
3.8 Central Role of Caspases................................89
3.9 Caspases Inhibitory Proteins............................90
3.10 Death Domains...........................................92
3.11 Fas/Fas Ligand..........................................92
3.12 TRAIL and Its Receptors.................................93
3.13 Conclusion..............................................95
References....................................................96
Chapter 4 Apoptotic Regulations.........................................Ю9
Key Words.....................................................Ю9
4.1 Introduction...........................................109
4.2 Etymology..............................................112
X
Contents
4.2.1 Major Pathways in Apoptosis: Intrinsic and
Extrinsic Pathways.............................113
4.2.1.1 Key Elements of the Apoptotic
Pathways................................114
4.2.2 Molecular Events Leading to Apoptosis...........114
4.2.2.1 Intrinsic Pathway.......................115
4.2.2.2 Extrinsic Pathway.......................119
4.2.3.3 Schematic Representation of Some
Major Apoptotic Signaling Pathways......124
4.2.3.4 Relationship between Intrinsic and
Extrinsic Apoptotic Pathways............125
4.2.3.5 Signal Transduction in Apoptosis........125
4.2.3.6 Mitochondrial Regulation of Apoptosis...130
4.3 Mechanisms of Apoptosis in Cancer......................133
4.3.1 Molecular Mechanisms of Apoptosis with
Pathogenicity...................................134
4.3.2 Caspase (Cysteine Protease) Organization........136
4.3.3 Apoptotic Regulators............................138
4.4 Role of Apoptotic Regulators in Rheumatoid Arthritis
(RA)....................................................138
4.5 Role of Apoptotic Regulators in Prostate Carcinoma.....139
4.6 Conclusion.............................................141
References....................................................142
Chapter 5 Dynamics of p53 in Oral Cancer................................149
Key Words.....................................................149
5.1 Introduction...........................................149
5.2 Functions and Roles in Causing Disease.................150
5.3 p53 as an Oncogene.....................................152
5.4 p53 as a Tumor Suppressor..............................152
5.5 Mutations in p53.......................................153
5.6 Apoptotic Regulation by p53............................153
5.7 Interplay between Survivin and p53.....................155
5.8 Clinicopathological Significance of p53................155
5.9 Therapeutic Strategies Targeting p53...................156
5.10 Conclusion.............................................157
References....................................................158
Chapter 6 Diagnostic and Therapeutic Potential of Apoptotic Marker......163
Key Words.....................................................163
6.1 Introduction...........................................163
6.2 Apoptotic Markers in Oral Cancer Therapeutics..........164
6.2.1 Gene Therapy....................................164
Contents
XI
6.2.2 Gene Therapy Strategies to Induce Apoptosis in
Oral Cancer Cells...............................165
6.2.2.1 Gene Addition Therapy...................165
6.2.2.2 Oncolytic Viruses.......................165
6.2.2.3 Suicide Gene Therapy....................166
6.2.2.4 Antisense RNA...........................166
6.2.3 Targeted Therapy................................166
6.2.3.1 Targets of Extrinsic Pathway............166
6.2.3.2 Targets of Intrinsic Pathway........... 167
6.2.3.3 Targeting p53.......................... 167
6.3 Apoptotic Markers in Oral Cancer Diagnostics............168
6.4 Conclusion..............................................169
References....................................................169
Chapter 7 Expression and Regulation of Survivin........................ 173
Key Words.....................................................173
7.1 Introduction............................................173
7.2 Molecular Organization and Structure of Survivin........173
7.2.1 Isoforms and Functions of Survivin............. 174
7.3 Functions of Survivin.................................. 175
7.3.1 Role of Survivin in Cell Division.............. 176
7.3.1.1 Association of Survivin with Other
Chromosomal Passenger Proteins.........177
7.3.1.2 Cell Division Network of Survivin...... 179
7.3.2 Role of Survivin in Apoptosis...................180
7.4 Regulation of Survivin................................. 185
7.4.1 Regulation by p53...............................185
7.4.2 Regulation of Survivin by c-Myc in BCR/ABL-
Transformed Cells.............................. 187
7.4.3 Regulation of Survivin by Hsp90.................187
7.5 Anti-Apoptotic Network of Survivin......................189
7.5.1 Providing a Heightened Cell Survival Threshold .... 189
7.5.2 Intermolecular Cooperation......................190
7.5.3 Mitochondrial Dynamics..........................190
7.6 Expression of Survivin in Normal Tissues................192
7.6.1 Survivin in Embryogenesis.......................192
7.7 Expression of Survivin in Human Cancer..................193
7.8 Conclusion..............................................195
References....................................................196
Chapter 8 Therapeutics of Survivin................................203
Key Words.....................................................203
8.1 Introduction............................................203
8.2 Manipulation of the Survivin Gene.......................204
XI!
Contents
8.3 Factors Inducing Survivin Expression....................205
8.4 Downregulation of Survivin..............................206
8.4.1 Antisense Technology............................206
8.4.2 Dominant Negative Construct.....................208
8.4.3 Acetylation and Deacetylation Pathway...........208
8.5 Ribozyme-Mediated Degradation of Survivin...............209
8.6 Immunotherapy...........................................209
8.7 Therapeutic Biology of Survivin.........................210
8.8 Survivin-Directed Cancer Therapy........................213
8.9 Regulation of Survivin in Head and Neck Squamous
Carcinoma...............................................214
8.10 Prognostic and Diagnostic Significance of Survivin......215
8.11 Therapeutic Approach....................................216
8.11.1 Antisense Oligonucleotides (ASONDs).............216
8.11.2 Survivin Ribozyme Approach......................216
8.11.3 Survivin RNA Interference Approach..............217
8.11.4 Survivin-Derived Cancer Immunotherapy...........217
8.11.5 Small-Molecule Inhibitors (SMIs)................218
8.12 Survivin for Cancer Immunotherapy.......................218
8.12.1 Activation of the Adaptive Immune System........218
8.12.1.1 Cellular T֊Cell Response...............218
8.12.1.2 Humoral Antibody Response..............219
8.13 Conclusion..............................................220
References....................................................220
Chapter 9 Molecular Diagnosis of Oral Cancer..............................229
Keywords......................................................229
9.1 Introduction............................................229
9.2 Molecular Markers for Oral Cancer.......................231
9.3 Molecular Mechanism of Development of Oral Cancer......231
9.4 The Hallmarks of Oral Cancer............................232
9.4.1 Self-Sufficiency in Growth Signals..............233
9.4.2 Insensitivity to Growth-Inhibitory (Antigrowth)
Signals.........................................233
9.4.3 Evasion of Programmed Cell Death (Apoptosis)...234
9.4.4 Limitless Replicative Potential or Immortalization. 234
9.4.5 Sustained Angiogenesis..........................234
9.4.6 Tissue Invasion and Metastasis..................234
9.5 Other Markers......................................... 235
9.6 Diagnosis of Oral Squamous Cell Carcinoma...............237
9.6.1 Cytological Techniques..........................237
9.6.1.1 Oral Brush Biopsy.......................237
9.6.1.2 Liquid-Based Cytology...................238
9.6.2 Molecular Analyses............................ 238
9.6.2.1 Gene Alterations........................238
Contents
XIII
9.6.3 Potential Biomarkers for OSCC...................240
9.6.3.1 Cytokeratin Fragments in the Serum...240
9.6.3.2 Toluidine Blue (TB)...................241
9.6.3.3 Light-Based Detection Systems.........241
9.6.3.4 Chemiluminescence.....................241
9.6.3.5 Tissue Fluorescence Imaging...........242
9.6.3.6 Tissue Fluorescence Spectroscopy......242
9.6.3.7 Exfoliative Cytology..................242
9.6.3.8 Biopsy and Histopathology.............243
9.6.3.9 Blood Markers.........................243
9.6.3.10 Saliva Markers........................243
9.6.3.11 Imaging...............................246
9.7 Conclusion...............................................246
References...................................................247
Glossary..................................................................255
Index.....................................................................263
Biology of
Oral Cancer
Key Apoptotic Regulators
Despite a decline in developed countries, cancer has consistently maintained
its status as one of the top killers since time immemorial. Exploring cancer
management and treatment at the molecular level, Biology of Oral Cancer: Key
Apoptotic Regulators presents a key molecular event-apoptosis—in relation
to genesis and progression of oral cancer. The book uses oral cancers as the
specific means to demonstrate the use of apoptotic regulators for controlling
cancers.
The book comprehensively deals with the different aspects of oral cancer.
The authors discuss strategies to leverage apoptotic regulatory mechanisms
for better management along with state-of-the-art medical options available
for management and treatment. Using an informal writing style that makes
the information accessible to a wider audience, each chapter begins with a
prologue followed by detailed discussion and concludes with a glimpse into
future approaches and challenges. The book examines detection techniques
that leverage molecular events associated with oral carcinogenesis to effectively
detect oral cancer.
Features
• Takes an innovative approach to the topic through the illustration of oral
cancers
• Presents a unique chapter on the molecular markers for the diagnosis of
oral cancer
• Contains the latest research in apoptotic techniques
• Includes contributors who are world-class experts in the field of oral
cancer biology
• Provides extensive references to enhance further study
A thorough examination of the internal (genetics) and external (carcinogens,
radiation, and smoking) factors that cause cancer, the book provides an
enhanced understanding of why oral cancer has consistently ranked among the
top ten causes of cancer-related mortalities worldwide. It furthers the effective
identification of the causal factors and their modulation that can restore cells
normal state and be used to develop increasingly effective modalities.
|
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| indexdate | 2024-07-10T07:50:39Z |
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| language | English |
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| spelling | Bisen, Prakash S. Verfasser (DE-588)1080543880 aut Biology of oral cancer key apoptotic regulators Prakash S. Bisen, Zakir Khan, Saurabh Bundela Oral cancer First issued in paperback Boca Raton ; London ; New York CRC Press 2017 xix, 272 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Mundhöhlenkrebs (DE-588)4040733-0 gnd rswk-swf Mundhöhlenkrebs (DE-588)4040733-0 s DE-604 Khan, Zakir 1979- Verfasser (DE-588)1038033497 aut Bundela, Saurabh 1977- Verfasser (DE-588)1038033632 aut Äquivalent Druck-Ausgabe, Hardback 978-1-4665-7558-5 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029758725&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029758725&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Bisen, Prakash S. Khan, Zakir 1979- Bundela, Saurabh 1977- Biology of oral cancer key apoptotic regulators Mundhöhlenkrebs (DE-588)4040733-0 gnd |
| subject_GND | (DE-588)4040733-0 |
| title | Biology of oral cancer key apoptotic regulators |
| title_alt | Oral cancer |
| title_auth | Biology of oral cancer key apoptotic regulators |
| title_exact_search | Biology of oral cancer key apoptotic regulators |
| title_full | Biology of oral cancer key apoptotic regulators Prakash S. Bisen, Zakir Khan, Saurabh Bundela |
| title_fullStr | Biology of oral cancer key apoptotic regulators Prakash S. Bisen, Zakir Khan, Saurabh Bundela |
| title_full_unstemmed | Biology of oral cancer key apoptotic regulators Prakash S. Bisen, Zakir Khan, Saurabh Bundela |
| title_short | Biology of oral cancer |
| title_sort | biology of oral cancer key apoptotic regulators |
| title_sub | key apoptotic regulators |
| topic | Mundhöhlenkrebs (DE-588)4040733-0 gnd |
| topic_facet | Mundhöhlenkrebs |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029758725&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029758725&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bisenprakashs biologyoforalcancerkeyapoptoticregulators AT khanzakir biologyoforalcancerkeyapoptoticregulators AT bundelasaurabh biologyoforalcancerkeyapoptoticregulators AT bisenprakashs oralcancer AT khanzakir oralcancer AT bundelasaurabh oralcancer |