Motor neuron disease in adults:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2015
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| Schriftenreihe: | Contemporary neurology series
88 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references |
| Beschreibung: | XXVIII, 336 S. Ill., graph. Darst. |
| ISBN: | 9780199783113 019978311X |
Internformat
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| 020 | |a 019978311X |9 0-19-978311-X | ||
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| 100 | 1 | |a Bromberg, Mark B. |e Verfasser |0 (DE-588)142055727 |4 aut | |
| 245 | 1 | 0 | |a Motor neuron disease in adults |c ed. by Mark B. Bromberg |
| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 2015 | |
| 300 | |a XXVIII, 336 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Contemporary neurology series |v 88 | |
| 500 | |a Includes bibliographical references | ||
| 650 | 2 | |a Motor Neuron Disease | |
| 650 | 2 | |a Adult | |
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Datensatz im Suchindex
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Titel: Motor neuron disease in adults
Autor: Bromberg, Mark B
Jahr: 2015
Contents
Preface xxi
Contributors xxiii
Introduction to "Motor Neuron Disease" xxv
Abbreviations xxvii
1. HISTORY OF THE RECOGNITION OF MOTOR NEURON DISEASE 1
Mark B. Bromberg
BACKGROUND AND NEW POINTS 1
HISTORICAL SETTING 1
HISTORICAL RECOGNITION OF MND 2
Bell • Aran • Duchenne and Cruveilhier • Charcot • Erb • Dejerine • Cowers • Brain
FAMILIAL MND 4
2. NOMENCLATURE AND CLASSIFICATION OF MOTOR NEURON DISEASE
Mark B. Bromberg
BACKGROUND AND NEW POINTS 5
INTRODUCTION 5
LOU GEHRIG 7
WEN RESEARCH CLASSIFICATION 7
PMA 9
PES 10
ALS BY PHENOTYPES 10
3. CLINICAL ANATOMY, PHYSIOLOGY, AND PATHOLOGY OF MOTOR
NEURON DISEASE 12
Mark B. Bromberg
BACKGROUND AND NEW POINTS 12
INTRODUCTION 12
ANATOMY 13
UMNs • LMNs
vi Contents
PATHOLOGY 14
ALS • PLS • PMA
PHYSIOLOGY AND PATHOPHYSIOLOGY 15
ALS • PLS • Frontotemporal Lobe
4. CLINICAL FEATURES OF MOTOR NEURON DISEASE 18
Mark B. Bromberg
BACKGROUND AND NEW POINTS 18
INTRODUCTION 18
COGNITIVE DYSFUNCTION IN NONDEMENTED PATIENTS WITH MND 18
FRONTOTEMPORAL LOBE DYSFUNCTION AND DEMENTIA 19
PSEUDOBULBAR AFFECT AND INCREASED YAWNING 21
BULBAR DYSFUNCTION 21
Dysarthria • Dysphagia
UPPER EXTREMITY DYSFUNCTION 23
LOWER EXTREMITY DYSFUNCTION 24
RESPIRATORY DYSFUNCTION 25
EYE MOVEMENT ABNORMALITIES 25
5. FRONTOTEMPORAL DYSFUNCTION AND DEMENTIA IN AMYOTROPHIC
LATERAL SCLEROSIS 27
Lauren Elman and Zachary Simmons
BACKGROUND AND NEW POINTS 27
INTRODUCTION 27
EPIDEMIOLOGY 28
CLINICAL FEATURES 28
DIAGNOSTIC CRITERIA AND CATEGORIZATION 29
ASSESSMENT OF COGNITIVE AND BEHAVIORAL DEFICITS 29
Cognitive Instruments • Behavioral Instruments • Combined Cognitive and
Behavioral Instruments
IMAGING 31
GENETICS AND PATHOLOGY 32
BIOMARKERS 34
CLINICAL RELEVANCE 35
EFFECT OF FTD ON COURSE AND PROGNOSIS 35
Contents
vii
IMPLICATIONS OF FTD FOR THE CAREGIVER 35
NONPHARMACOLOGIC MANAGEMENT OF FTD 36
PHARMACOLOGIC MANAGEMENT OF ALS-FTD 36
CONCLUSION 38
6. LABORATORY TESTS FOR MOTOR NEURON DISEASE 42
Mark B. Bromberg
BACKGROUND AND NEW POINTS 42
INTRODUCTION 42
NERVE CONDUCTION TESTING 43
NERVE CONDUCTION TESTS FOR UMN LOSS 43
NEEDLE EMG TESTING 43
EMG ABNORMALITIES IN INDIVIDUAL MUSCLES 44
Cervical and Lumbosacral Muscles • Cranial Muscles • Diaphragm • Thoracic and Rectus
Abdominis Muscles
MUSCLE BIOPSY 45
SEROLOGIC AND SPINAL FLUID LABORATORY STUDIES 45
Serum Creatine Kinase • Cerebrospinal Fluid
CENTRAL NERVOUS SYSTEM IMAGING 46
MUSCLE IMAGING 46
M RI • Ultrasound
FRONTOTEMPORAL LOBE TESTING 48
7. BIOMARKERS FOR MOTOR NEURON DISEASE 50
Shafeeq Ladha, Christina Chrisman, and Robert Bowser
BACKGROUND AND NEW POINTS 50
INTRODUCTION 50
GENETIC BIOMARKERS 51
PROTEIN BIOMARKERS 53
METABOLIC BIOMARKERS 57
NEUROPHYSIOLOGY BIOMARKERS 58
MUNE • MUNE in ALS Studies • EIM • TMS
IMAGING BIOMARKERS 65
Conventional M RI • MRS • DTI • Voxel-based Morphometiy • IMRI
CONCLUSIONS AND FUTURE DIRECTIONS 67
vili Contents
8. IMAGING IN MOTOR NEURON DISEASE 75
Martin R. Turner
BACKGROUND AND NEW POINTS 75
INTRODUCTION 75
TYPES OF NEUROIMAGING 76
NEUROIMAGING FOR DIAGNOSTIC EXCLUSION 77
NEUROIMAGING AS A BIOMARKER 80
CORE CEREBRAL MOTOR PATHOLOGY 80
Voxel- and Surface-based Morphometry • DTI • Spectroscopy
EXTRAMOTOR CEREBRAL PATHOLOGY 84
Radionuclide Imaging • VBM • DTI • Spectroscopy • fMRI
MECHANISTIC IMAGING 86
Loss of Cortical Inhibitory Influence • Neuroinflammation • Serotonergic Involvement
FUTURE DIRECTIONS 88
Imaging in Animal Models • Spinal Cord • Presymptomatic Pathology • Network-based
Approaches
CONCLUSION 89
9. DIAGNOSTIC CRITERIA FOR MOTOR NEURON DISEASE 94
Mark B. Bromberg
BACKGROUND AND NEW POINTS 94
INTRODUCTION 94
TIME TO DIAGNOSIS 94
ALS 95
El Escoriai Criteria • Airlie House Criteria • Awaji Criteria • Pending El Escoriai Review
WORLD FEDERATION OF NEUROLOGY CRITERIA PERFORMANCE
REVIEWS 97
PES 98
PMA 100
10. DIFFERENTIAL DIAGNOSIS OF MOTOR NEURON DISEASE 102
Mark B. Bromberg
BACKGROUND AND NEW POINTS 102
DIFFERENTIAL DIAGNOSIS OF ALS 102
KENNEDY DISEASE 102
MULTIFOCAL MOTOR NEUROPATHY 103
INCLUSION BODY MYOSITIS 105
Contents ix
SPONDYLOTIC RADICULOPATHY AND MYELORADICULOPATHY 105
MONONEUROPATHIES 106
MYASTHENIA GRAVIS 106
HEREDITARY SPASTIC PARESIS 106
LYME DISEASE 107
VIRAL DISEASES 107
RETROVIRAL DISEASES 107
HEAVY METAL TOXICITY 107
CANCER AND PARANEOPLASTIC SYNDROMES 107
11. MOTOR NEURON DISEASE PROGRESSION 109
Mark B. Bromberg
BACKGROUND AND NEW POINTS 109
INTRODUCTION 109
CLINICAL PROGRESSION 110
ALS • PBP • PMA • PLS
CLINIMETRIC SCALES 112
Composite Scales • Motor Unit Number Estimation • Motor Unit Number Index • CMAP
Scan • Neurophysiology Index • Electrical Impedance Myography • Muscle
Ultrasound • MRI • ALSFRS
QUANTITATING PROGRESSION 115
ALS STAGING 116
PREDICTION OF PROGRESSION AND SURVIVAL 116
12. EPIDEMIOLOGY OF AMYOTROPHIC LATERAL SCLEROSIS 119
Adriano Chiò and Giancarlo Logroscino
BACKGROUND AND NEW POINTS 119
INTRODUCTION 119
DESCRIPTIVE EPIDEMIOLOGY 120
Methodologie Considerations • Incidence • Prevalence • Mortality
ALS TIME TRENDS 122
GENETIC EPIDEMIOLOGY 123
COGNITIVE CHANGES AND MOTOR NEURON DEGENERATION IN
POPULATION-BASED STUDIES 125
FTD: NEW END OF THE ALS SPECTRUM? 126
ALS PROGNOSTIC FACTORS 127
X
Contents
13. GENETICS OF AMYOTROPHIC LATERAL SCLEROSIS AND
FRONTOTEMPORAL DEMENTIA 133
Janel O. Johnson and Bryan J. Traynor
BACKGROUND AND NEW POINTS 133
INTRODUCTION 133
ALS 134
LTD 135
FTLD AND ALS OVERLAP 136
Ends of the Spectrum • SODI in ALS • MAPT in FTLD
GENES WITH POSSIBLE ALS AND FTLD OVERLAP 138
PGRN Mutations • TDP-43 Mutations • FUS Mutations • CHMP2B Mutations • OPTN •
VCP • SQSTM1 • UBQLN2 • C9orf72 • hnRNPABl/2
GENERAL CONSIDERATIONS FOR GENETIC TESTING IN ALS AND FTLD 144
14. GENOME WIDE APPROACHES TO IDENTIFY AMYOTROPHIC LATERAL
SCLEROSIS ASSOCIATED GENES 150
John E. Landers and Nicola Ticozzi
BACKGROUND AND NEW POINTS 150
INTRODUCTION 150
LINKAGE ANALYSIS 153
CANDIDATE GENE APPROACH 155
GENOME-WIDE ASSOCIATION STUDIES 155
HOMOZYGOZITY MAPPING 157
EXOME SEQUENCING 158
FUTURE DIRECTIONS 160
15. PATHOLOGY OF AMYOTROPHIC LATERAL SCLEROSIS AND
FRONTOTEMPORAL LOBAR DEGENERATION 163
Andrew King and Safa Al-Sarraj
BACKGROUND AND NEW POINTS 163
INTRODUCTION 164
DEFINITIONS 164
ALS/Motor Neuron Disease • FTLD • FTLD-MND/ALS
PROTEIN INCLUSIONS 165
Ubiquitin • p62 • TDP-43 • FUS
PATHOLOGY OF SPORADIC ALS 166
Spinal Cord • Brainstem • Motor Cortex • Extramotor Structures • Muscle
Contents xi
PATHOLOGY OF FAMILIAL ALS (FALS) 168
SODI * C90RF72 • FUS • CHMP2B, TARDP, p62, UBQLN2 • ALS-Parkinson Dementia
Complex • Spinal Bulbar Muscular Atrophy
PATHOLOGY OF FTLD 170
SUBTYPING OF CEREBRAL PATHOLOGY OF FTLD-TDP AND FTLD-MND/
ALS 171
Type A • Type B • Type C • Type D
FTLD-FUS 172
PATHOLOGY OF FAMILIAL FTLD 172
HEAD TRAUMA AND TDP-43 172
16. CONVERGENCE AND DIVERGENCE IN AMYOTROPHIC LATERAL
SCLEROSIS SYNDROME: GENETICS, MOLECULAR PATHWAYS, AND
MOLECULAR MECHANISMS 174
Lucie I. Bruijn and John Ravits
BACKGROUND AND NEW POINTS 174
INTRODUCTION 174
MOLECULAR NEUROPATHOLOGY 175
CLINICAL AND PATHOLOGIC HOMOGENEITY AND
UNDERLYING MECHANISMS 179
Hypotheses of Propagation • Parallels to FTD
PATHOGENESIS 180
Prime Observations • Motor Neuron Resistance and Vulnerability in ALS • ALS as a Systemic
Disease • The Cellular Neighborhood Matters: Nonautonomous Cell Death • RNA Processing and
RNA Toxicity • Disruption of Protein Homeostasis • Prion-like Propagation • Corticospinal Motor
Neuron Development, Degeneration, and Subcerebral Projections • Disruption of Axonal Dynamics
CONCLUDING REMARKS 186
17. IMMUNOLOGIC ASPECTS OF AMYOTROPHIC LATERAL SCLEROSIS 190
Tamara S. Greene, Ericka P. Simpson, and Stanley H. Appel
BACKGROUND AND NEW POINTS 190
INTRODUCTION 190
ROLE OF MICROGLIA IN ALS _191
ASTROCYTES AND ALS 192
CYTOKINES, CHEMOKINES, AND OTHER MARKERS OF INFLAMMATION
IN ALS 193
T CELLS IN ALS 194
DENDRITIC CELLS 194
xii Contents
TREATMENT TARGETING IMMUNE MECHANISMS AND
NEUROINFLAMMATION 195
CONCLUSION 195
18. CYANOBACTERIA, AMYOTROPHIC LATERAL SCLEROSIS, AND THE
BMAA HYPOTHESIS 198
Tracie A. Caller, Elijah W. Stommel, Patricia L. Henegan, and Sandra Anne Banack
BACKGROUND AND NEW POINTS 198
INTRODUCTION 198
THE GUAM HYPOTHESIS 199
Mechanisms of BMAA Toxicity
BEYOND GUAM 201
CONCLUSION 202
19. ANIMAL MODELS OF ADULT MOTOR NEURON DISEASE 207
Kerstin E. Braunstein, Liant L. Chen, and Philip C. Wong
BACKGROUND AND NEW POINTS 207
INTRODUCTION 207
INVERTEBRATE MODELS 209
Drosophila and Caenorhabditis elegans Models • SODI • Dynactin
plSQGM . TDP-43 • FUS • C90RF72
VERTEBRATE MODELS 211
Zebrafish • Rodent Models
CONCLUSION 217
20. MULTIDISCIPLINARY CLINICS AND PRACTICE PARAMETERS
AND GUIDELINES 221
Mark B. Bromberg
BACKGROUND AND NEW POINTS 221
INTRODUCTION 221
PRACTICE PARAMETERS AND GUIDELINES AND MULTIDISCIPLINARY
CLINICS 222
CLINIC PROVIDERS 222
IMPACT OF PRACTICE PARAMETERS AND GUIDELINES 222
CLINIC CHALLENGES 224
Delivering the Diagnosis • Providing Hope • Managing Key Time Points • Addressing End
of Life • Bereavement
Contents xiii
CLINIC STRESS 226
CLINIC BENEFITS 226
CLINICAL CARE QUALITY IMPROVEMENT 226
21. ALLIED HEALTH AND OTHER PROVIDERS 228
Mark B. Bromberg
BACKGROUND AND NEW POINTS 228
INTRODUCTION 228
PULMONOLOGY 229
GASTROENTEROLOGY, INTERVENTIONAL RADIOLOGY, AND SURGERY 229
PSYCHIATRY AND PSYCHOLOGY 230
PHYSICAL, OCCUPATIONAL, AND RESPIRATORY THERAPY 230
Physical and Occupational Therapists • - Respiratory Therapists
NURSING 231
NUTRITION 231
SPEECH THERAPY 231
GENETIC COUNSELING 231
ORTHOTICS 232
WHEELCHAIR SEATING 232
DRIVING EVALUATIONS 232
CLERGY 232
ASSISTIVE TECHNOLOGY 233
TIME LINE OF DURABLE EQUIPMENT NEEDS 233
EXERCISE 233
Possible Harmful Effects of Exercise
FALLS 235
22. RESPIRATORY ASSESSMENT AND MANAGEMENT 237
Mark B. Bromberg
BACKGROUND AND NEW POINTS 237
INTRODUCTION 238
RESPIRATORY ANATOMY AND PHYSIOLOGY 238
ALS PROGRESSION AND RESPIRATORY FAILURE 238
xiv Contents
SLEEP-DISORDERED BREATHING 239
EARLY DIAPHRAGM DYSFUNCTION 239
RESPIRATORY METRICS 239
Methods of Testing • Respiratory Survey Questionnaires and Instruments
NIV 240
Bilevel Ventilation
RESPIRATORY THRESHOLD FOR NIV 241
PREDICTORS OF NIV USE 242
EARLY VERSUS LATE USE OF NIV 242
EFFICACY OF NIV 242
LONG-TERM EFFECTS OF NIV 242
Survival and Quality of Life • Sleep
PREDICTORS OF NONINVASIVE USE 243
SUPPLEMENTAL OXYGEN 243
ELECTRICAL PHRENIC NERVE AND DIAPHRAGM STIMULATION 244
Phrenic Nerve Stimulation • Diaphragm Pacing
LONG-TERM MECHANICAL VENTILATION 245
PATIENT AUTONOMY FOR RESPIRATORY DECISIONS 245
COUGH AUGMENTATION 245
Air or Breath Stacking • Insufflation and Exsufflation Devices
INSPIRATORY MUSCLE EXERCISE 246
HIGH-FREQUENCY CHEST WALL OSCILLATORY TREATMENT 246
ASPIRATION PNEUMONIA 246
CAUSE OF DEATH IN ALS AND END-OF-LIFE CARE 247
23. NUTRITIONAL ASSESSMENT AND MANAGEMENT 249
Mark B. Bromberg
BACKGROUND AND NEW POINTS 249
INTRODUCTION 249
PREMORBID WEIGHT AND RISK OF DEVELOPING ALS 249
WEIGHT LOSS OVER THE COURSE OF ALS 250
EFFECT OF WEIGHT LOSS 250
NUTRITIONAL ASSESSMENT 250
METABOLIC RATES 251
Ì
Contents xv
SEROLOGIC NUTRITIONAL COMPONENTS 251
NUTRITIONAL INTERVENTIONS 252
Nutritional Supplements • Gastric Feeding Tubes
24. COMMUNICATION ASSESSMENT AND MANAGEMENT 254
Mark B. Bromberg
BACKGROUND AND NEW POINTS 254
INTRODUCTION 254
SPEECH PRODUCTION AND DYSARTHRIA 255
SPEECH ASSESSMENT SCALES 255
SPEECH EXERCISES 255
COMPENSATORY SPEECH STRATEGIES 255
PALATAL LIFT AND AUGMENTATION 256
AUGMENTATIVE AND ALTERNATIVE COMMUNICATION 256
IMPACT OF COMMUNICATION DEVICES 256
BRAIN-COMPUTER INTERFACE 257
FRONTOTEMPORAL LOBE DYSFUNCTION EFFECT ON
COMMUNICATION 258
25. PSYCHOLOGICAL AND PSYCHIATRIC ASSESSMENT AND
MANAGEMENT 259
Mark B. Bromberg
BACKGROUND AND NEW POINTS 259
INTRODUCTION 259
DEPRESSION 259
BEHAVIORAL SYMPTOMS 260
26. SYMPTOMS AND MANAGEMENT 261
Mark B. Bromberg
BACKGROUND AND NEW POINTS 261
INTRODUCTION 261
BEHAVIORAL DISTURBANCE 263
PSEUDOBULBAR AFFECT 263
EXCESSIVE YAWNING 263
ANXIETY AND DEPRESSION 263
xvi Contents
WEAKNESS 263
SHORTNESS OF BREATH 264
FATIGUE 264
FASCICULATIONS 264
SPASTICITY AND SPASMS 264
CRAMPS 265
SIALORRHEA 265
THICK PHLEGM 266
LARYNGEAL SPASMS 266
PAIN 266
DISRUPTED SLEEP 267
CONSTIPATION 267
BLADDER AND BOWEL INCONTINENCE 267
URINARY DISORDERS 267
DEPENDENT LIMB SYMPTOMS 268
DEEP VENOUS THROMBOSIS 268
SKIN BREAKDOWN 268
SWEATING 268
27. INTIMACY, SEXUALITY, AND PREGNANCY 271
Mark B. Bromberg
BACKGROUND AND NEW POINTS 271
INTRODUCTION 271
INTIMACY 271
SEXUALITY 272
PREGNANCY WITH ALS 272
INAPPROPRIATE SEXUAL BEHAVIOR 272
28. QUALITY OF LIFE 274
Mark B. Bromberg
BACKGROUND AND NEW POINTS 274
INTRODUCTION 274
TYPES OF INSTRUMENTS 274
Contents xvii
QUALITY OF LIFE FOR THE PATIENT AND CAREGIVER 275
Patient Quality of Life • Hopelessness and Suicidal Ideation • Response Shift • Caregiver Quality
of Life
PERCEPTIONS OF QUALITY OF LIFE 276
FACTORS AFFECTING QUALITY OF LIFE 277
29. CAREGIVER ISSUES 279
Mark B. Bromberg
BACKGROUND AND NEW POINTS 279
INTRODUCTION 279
IMPACT OF MND ON CAREGIVERS 279
LONGITUDINAL QUALITY OF LIFE BETWEEN PATIENT AND
CAREGIVER 280
LONGITUDINAL EFFECT OF CAREGIVER BURDEN 280
EFFECT OF PATIENT'S BEHAVIORAL DYSFUNCTION 281
CAREGIVER COPING 281
POSITIVE FACTORS FOR CAREGIVERS 281
30. END OF LIFE CARE 283
Mark B. Bromberg
BACKGROUND AND NEW POINTS 283
INTRODUCTION 283
TIME LINE OF MND CARE 284
PATIENT DECISION-MAKING 284
LEGAL DOCUMENTS 285
HOSPICE 285
TIME IN HOSPICE 286
END-OF-LIFE PATIENT CONCERNS ABOUT MANNER OF DEATH 286
PALLIATING PAIN 287
SUICIDE IN PATIENTS WITH ALS 287
MANAGING THE PROCESS OF DYING 288
PLACE OF DEATH 288
BEREAVEMENT 289
ORGAN DONATION 289
xviii Contents
31. COSTS OF AMYOTROPHIC LATERAL SCLEROSIS CARE 291
Mark B. Bromberg
BACKGROUND AND NEW POINTS 291
INTRODUCTION 291
DRUGS TO TREAT ALS 292
Riluzole • Nuedexta
COMPLEMENTARY ALTERNATIVE MEDICATIONS AND PROCEDURES 292
DRUGS TO MANAGE SYMPTOMS 293
INTERVENTIONS 293
Noninvasive Ventilation • Invasive Ventilation • Gastric Feeding Tubes • Diaphragm Pacing
DURABLE MEDICAL EQUIPMENT 294
CLINICAL CARE COSTS 294
HOSPITALIZATION COSTS 296
HOSPICE CARE COSTS 296
ALS COSTS COMPARED WITH OTHER DISEASES 296
VETERANS ADMINISTRATION AND ALS 297
MEDICARE AND ALS 297
32. CLINICAL TRIAL DESIGNS IN AMYOTROPHIC LATERAL SCLEROSIS 298
Dan H. Moore and Mark B. Bromberg
BACKGROUND AND NEW POINTS 298
INTRODUCTION 298
CLINICAL TRIAL PHASES 299
CLINICAL TRIAL DESIGN 299
COMPARISON GROUPS 299
ONLINE SELF-REPORTED PATIENT DATA 302
ENDPOINT MEASURES 303
METHODS OF ANALYSIS 304
TYPES OF TRIALS 305
Randomized Trials • Multiarm Trials • Lead-in Trials • Cross-over Trials • Sequential
Trials • Bayesian Trials
SUBJECT SELECTION 307
CLINICAL TRIAL OPERATIONS 308
Contents xix
DISCUSSION 308
DISCLAIMER 309
33. STEM CELL THERAPY FOR MOTOR NEURON DISEASE 312
Stacey A. Sakowski,J. Simon Lunn, and Eva L. Feldman
BACKGROUND AND NEW POINTS 312
INTRODUCTION 312
CONSIDERATIONS FOR STEM CELL THERAPY DEVELOPMENT 313
Stem Cell Classifications and Properties
CELLULAR THERAPY EXPECTATIONS FOR ALS 315
DELIVERY APPROACHES FOR CELLULAR THERAPY 317
SUPPORTING DATA FOR ALS STEM CELL THERAPIES 318
In Vitro Mechanistic Rationale • In Vivo Support for Clinical Translation
CLINICAL APPLICATION AND PROGRESS 321
MSC Trials • Neural Stem Cell Trials
LOOKING INTO THE FUTURE 323
Index 329 |
| any_adam_object | 1 |
| author | Bromberg, Mark B. |
| author_GND | (DE-588)142055727 |
| author_facet | Bromberg, Mark B. |
| author_role | aut |
| author_sort | Bromberg, Mark B. |
| author_variant | m b b mb mbb |
| building | Verbundindex |
| bvnumber | BV042362485 |
| classification_rvk | YG 6300 |
| ctrlnum | (OCoLC)904177942 (DE-599)HBZHT018412680 |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV042362485 |
| illustrated | Illustrated |
| indexdate | 2024-08-14T00:53:41Z |
| institution | BVB |
| isbn | 9780199783113 019978311X |
| language | English |
| lccn | 2014008930 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027798904 |
| oclc_num | 904177942 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XXVIII, 336 S. Ill., graph. Darst. |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| series | Contemporary neurology series |
| series2 | Contemporary neurology series |
| spelling | Bromberg, Mark B. Verfasser (DE-588)142055727 aut Motor neuron disease in adults ed. by Mark B. Bromberg Oxford [u.a.] Oxford Univ. Press 2015 XXVIII, 336 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Contemporary neurology series 88 Includes bibliographical references Motor Neuron Disease Adult Krankheit (DE-588)4032844-2 gnd rswk-swf Motoneuron (DE-588)4135747-4 gnd rswk-swf Motoneuron (DE-588)4135747-4 s Krankheit (DE-588)4032844-2 s DE-604 Contemporary neurology series 88 (DE-604)BV000898796 88 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027798904&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bromberg, Mark B. Motor neuron disease in adults Contemporary neurology series Motor Neuron Disease Adult Krankheit (DE-588)4032844-2 gnd Motoneuron (DE-588)4135747-4 gnd |
| subject_GND | (DE-588)4032844-2 (DE-588)4135747-4 |
| title | Motor neuron disease in adults |
| title_auth | Motor neuron disease in adults |
| title_exact_search | Motor neuron disease in adults |
| title_full | Motor neuron disease in adults ed. by Mark B. Bromberg |
| title_fullStr | Motor neuron disease in adults ed. by Mark B. Bromberg |
| title_full_unstemmed | Motor neuron disease in adults ed. by Mark B. Bromberg |
| title_short | Motor neuron disease in adults |
| title_sort | motor neuron disease in adults |
| topic | Motor Neuron Disease Adult Krankheit (DE-588)4032844-2 gnd Motoneuron (DE-588)4135747-4 gnd |
| topic_facet | Motor Neuron Disease Adult Krankheit Motoneuron |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027798904&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000898796 |
| work_keys_str_mv | AT brombergmarkb motorneurondiseaseinadults |