Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	Bona, Constantin A. (VerfasserIn), Bot, Adrian I. (VerfasserIn)
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Boston, MA Springer US 2000
Schlagworte:	Immunology Allergology Medical Microbiology Cancer Research Public Health Allergy Microbiology Oncology Immunisierung DNS Impfstoff
Online-Zugang:	UBR01 Volltext
Zusammenfassung:	Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto­ immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids
Beschreibung:	1 Online-Ressource (XII, 180 p)
ISBN:	9781475731637
DOI:	10.1007/978-1-4757-3163-7