Verfügbarkeit: Galactose regulon of yeast

Galactose regulon of yeast: from genetics to systems biology

Gespeichert in:

Bibliographische Detailangaben
1. Verfasser:	Bhat, Paike Jayadeva (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Berlin [u.a.] Springer 2008
Schlagworte:	Galactose Galactose > genetics Regulon > genetics Systems biology Yeast fungi > Molecular genetics Yeasts Galactose-Operon Hefeartige Pilze Genregulation Regulon Saccharomyces cerevisiae
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XIV, 219 S. Ill., graph. Darst.
ISBN:	9783540740148 3540740147

Internformat

MARC


LEADER	00000nam a2200000 c 4500
001	BV023110336
003	DE-604
005	20080314
007	t
008	080201s2008 gw ad\|\| \|\|\|\| 00\|\|\| eng d
016	7		\|a 986339210 \|2 DE-101
020			\|a 9783540740148 \|c Gb. : EUR 128.35 (freier Pr.), sfr 209.00 (freier Pr.) \|9 978-3-540-74014-8
020			\|a 3540740147 \|c Gb. : EUR 128.35 (freier Pr.), sfr 209.00 (freier Pr.) \|9 3-540-74014-7
035			\|a (OCoLC)229442649
035			\|a (DE-599)DNB986339210
040			\|a DE-604 \|b ger \|e rakddb
041	0		\|a eng
044			\|a gw \|c XA-DE-BE
049			\|a DE-355 \|a DE-188
082	0		\|a 572.86529562 \|2 22/ger
084			\|a WG 1940 \|0 (DE-625)148511: \|2 rvk
084			\|a 570 \|2 sdnb
100	1		\|a Bhat, Paike Jayadeva \|e Verfasser \|4 aut
245	1	0	\|a Galactose regulon of yeast \|b from genetics to systems biology \|c Paike Jayadeva Bhat
264		1	\|a Berlin [u.a.] \|b Springer \|c 2008
300			\|a XIV, 219 S. \|b Ill., graph. Darst.
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
650		4	\|a Galactose
650		4	\|a Galactose \|x genetics
650		4	\|a Regulon \|x genetics
650		4	\|a Systems biology
650		4	\|a Yeast fungi \|x Molecular genetics
650		4	\|a Yeasts
650	0	7	\|a Galactose-Operon \|0 (DE-588)4325829-3 \|2 gnd \|9 rswk-swf
650	0	7	\|a Hefeartige Pilze \|0 (DE-588)4230509-3 \|2 gnd \|9 rswk-swf
650	0	7	\|a Genregulation \|0 (DE-588)4122166-7 \|2 gnd \|9 rswk-swf
650	0	7	\|a Regulon \|0 (DE-588)4353205-6 \|2 gnd \|9 rswk-swf
650	0	7	\|a Saccharomyces cerevisiae \|0 (DE-588)4178812-6 \|2 gnd \|9 rswk-swf
650	0	7	\|a Galactose \|0 (DE-588)4155818-2 \|2 gnd \|9 rswk-swf
689	0	0	\|a Hefeartige Pilze \|0 (DE-588)4230509-3 \|D s
689	0	1	\|a Galactose \|0 (DE-588)4155818-2 \|D s
689	0	2	\|a Regulon \|0 (DE-588)4353205-6 \|D s
689	0		\|5 DE-604
689	1	0	\|a Saccharomyces cerevisiae \|0 (DE-588)4178812-6 \|D s
689	1	1	\|a Galactose-Operon \|0 (DE-588)4325829-3 \|D s
689	1	2	\|a Genregulation \|0 (DE-588)4122166-7 \|D s
689	1		\|C b \|5 DE-604
856	4	2	\|m Digitalisierung UB Regensburg \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016312944&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
999			\|a oai:aleph.bib-bvb.de:BVB01-016312944

Datensatz im Suchindex

_version_	1804137372981395456
adam_text	Contents 1 Introduction. 1.1 An Overview ...................................................................................... 1 1.1.1 A General Perspective ............................................................ 1 1.1.2 An Aside on Analogy ............................................................. 2 References ................................................................................................... 3 1.2 Yeast is a Eukaryotic Model Organism ............................................. 4 1.2.1 Introduction ............................................................................ 4 1.2.2 Model Organisms ................................................................... 4 1.2.3 Yeast ....................................................................................... 5 1.2.4 Life Cycle of Haploid Yeast ................................................... 7 1.2.5 Life Cycle of Diploid Yeast ................................................... 9 1.2.6 Information Transfer from Parents to Descendents ............... 9 1.2.7 Human Life Cycle .................................................................. 13 References ................................................................................................... 14 1.3 A Cell as a Biochemical Entity ......................................................... 15 1.3.1 Introduction ............................................................................ 15 1.3.2 Chemical Constituents ............................................................ 15 1.3.3 Macroscopic and Microscopic Aspects of Metabolism ......................................................................... 16 1.3.4 Biochemical Transactions ....................................................... 17 1.3.5 Energy Transactions ............................................................... 19 References ................................................................................................... 23 2 Adaptation to Environment ...................................................................... 25 2.1 Growth and Multiplication ................................................................ 25 2.1.1 Introduction ............................................................................ 25 2.1.2 Growth Kinetics ...................................................................... 25 2.1.3 Effect of Nutrients on Growth ................................................ 28 2.1.4 Metabolic Strategy .................................................................. 29 References ................................................................................................... 33 x Contents 2.2 Enzyme Adaptation........................................................................... 33 2.2.1 Introduction............................................................................ 33 2.2.2 Adaptation to Nutrients .......................................................... 33 2.2.3 Long-Term Adaptation ........................................................... 35 2.2.4 Single-Cell Analysis of Long-Term Adaptation .................... 36 2.2.5 Galactose Metabolism ............................................................ 38 References ................................................................................................... 41 2.3 Induction of Leloir Enzymes ............................................................. 42 2.3.1 Introduction ............................................................................ 42 2.3.2 Galactose Induces the Synthesis of Leloir Enzymes .................................................................. 43 2.3.3 Galactose Activates the Transcription of GAL Genes ......................................................................... 43 2.3.4 Galactose Activates a Genetic Program ................................. 46 References ................................................................................................... 47 3 Genetic Dissection of Galactose Metabolism ........................................... 49 3.1 Genetic Analysis of GAL Regulon .................................................... 49 3.1.1 Introduction ............................................................................ 49 3.1.2 Mutant Hunt ........................................................................... 49 3.1.3 Segregation Analysis .............................................................. 50 3.1.4 Complementation Analysis .................................................... 50 3.1.5 Concept of an Alíele ............................................................... 54 3.1.6 Special Cases of Complementation ........................................ 56 3.1.7 Aberrant Segregation and Recombination Model .................. 58 References ................................................................................................... 61 3.2 Genetic Mapping of GAL Genes ....................................................... 62 3.2.1 Introduction ............................................................................ 62 3.2.2 Tetrad Analysis ....................................................................... 62 3.2.3 Mapping of GAL Genes by Tetrad Analysis .......................... 64 3.2.4 Map Distance and Recombination Frequency ....................... 67 3.2.5 An Aside on Mapping of Human Genes by Linkage Analysis ............................................................... 69 References ................................................................................................... 76 4 Genetic Analysis GAL Genetic Switch ..................................................... 79 4.1 Negative Control by the Repressor .................................................... 79 4.1.1 Introduction ............................................................................ 79 4.1.2 Discovery of a Repressor of GAL Regulon ............................ 80 Reference .................................................................................................... 82 4.2 Operator Repressor Model of GAL Regulon ..................................... 82 4.2.1 Introduction ............................................................................ 82 4.2.2 Testing the Predictions of the Model ..................................... 82 References ................................................................................................... 84 Contents xi 4.3 Genetic Interactions ........................................................................... 85 4.3.1 Introduction ............................................................................ 85 4.3.2 Recessivity and Dominance ................................................... 85 4.3.3 Negative Dominance .............................................................. 87 4.3.4 Epistasis .................................................................................. 87 4.3.5 Allele-Specific Interactions .................................................... 89 References ................................................................................................... 90 4.4 Conditional Lethal Mutations ............................................................ 90 4.4.1 Introduction ............................................................................ 90 4.4.2 Temperature-Sensitive Alíele of GAL3 .................................. 91 4.4.3 Temperature-Sensitive Alíele of GAL4 .................................. 92 References ................................................................................................... 93 4.5 Revised Model of GAL Genetic Switch ............................................ 94 4.5.1 Introduction ............................................................................ 94 4.5.2 Protein-Protein Interaction Model ......................................... 94 4.5.3 Interaction Between GAL4 and GAL80 Proteins .................. 95 References ................................................................................................... 97 4.6 Signal Transduction in GAL Regulon ................................................ 97 4.6.1 Introduction ............................................................................ 97 4.6.2 Catalytic Model ...................................................................... 98 References ................................................................................................... 99 5 Molecular Genetics of GAL Regulon ........................................................ 101 5.1 Cloning: A Perspective ...................................................................... 101 5.1.1 Introduction ............................................................................ 101 5.1.2 Vectors, Genetic Transformation, and Recombinant DNA Technology ...................................... 102 5.1.3 DNA Cloning .......................................................................... 104 5.1.4 Genomic DNA Library ........................................................... 105 5.1.5 cDNA Library ......................................................................... 105 5.1.6 Isolation of Recombinant Clones ........................................... 106 5.1.7 Development of Yeast Shuttle Vectors ................................... 107 References ................................................................................................... 110 5.2 Genomic Organization of GAL Cluster ............................................. 110 5.2.1 Introduction ............................................................................ 110 5.2.2 Cloning of the GAL Cluster .................................................... 111 5.2.3 Analysis of GAL1-I0 Intergenic Region ................................ 113 References ................................................................................................... 118 5.3 Isolation of GALĄ: The Transcriptional Activator ............................ 118 5.3.1 Introduction ............................................................................ 118 5.3.2 Cloning of GAL4 by Functional Complementation ............... 120 5.3.3 GAL4 Protein Binds Upstream Activating Sequences ............................................................................... 120 5.3.4 GAL4 Protein Binds GAL80 Protein ..................................... 123 xii Contents 5.3.5 GAL4 Protein is Modular ....................................................... 124 References ................................................................................................... 129 5.4 Isolation of GAL80: The Repressor ................................................... 131 5.4.1 Introduction ............................................................................ 131 5.4.2 Cloning of GAL80 by Genetic Suppression ........................... 131 5.4.3 Autogenous Regulation of GAL80 Expression ...................... 132 5.4.4 Mutational Analysis of GAL80 .............................................. 133 References ................................................................................................... 134 5.5 Isolation of GAL3: The Signal Transducer ........................................ 135 5.5.1 Introduction ............................................................................ 135 5.5.2 Cloning of GAU.................................................................... 135 5.5.3 GALI and GAL3 are Paralogues ............................................ 137 5.5.4 GALI is a Degenerate Signal Transducer .............................. 137 5.5.5 Autogenous Regulation of GAL3 Expression ........................ 138 5.5.6 An aside on Positional Cloning .............................................. 138 5.5.7 Restriction Fragment Length Polymorphism ......................... 141 References ................................................................................................... 141 6 Signal Transduction Revisited .................................................................. 143 6.1 Revised Model of Signal Transduction ............................................. 143 6.1.1 Introduction ............................................................................ 143 6.1.2 Protein-Protein Interaction Model ......................................... 143 6.1.3 Testing the Predictions of the Protein-Protein Interaction Model ................................................................... 144 6.1.4 Recent Analysis of Signal Transduction ................................ 145 References ................................................................................................... 150 6.2 Genetic Dissection of Signal Transduction ....................................... 150 6.2.1 Introduction ............................................................................ 150 6.2.2 Mutational Analysis of GAL3 ................................................ 151 6.2.3 Mutational Analysis of GAL80 .............................................. 154 References ................................................................................................... 155 7 Versatile Galactose Genetic Switch .......................................................... 157 7.1 Transcription Activation .................................................................... 157 7.1.1 Introduction ............................................................................ 157 7.1.2 RNA Polymerase II ................................................................ 158 7.1.3 Transcriptional Activation by Recruitment ............................ 159 References ................................................................................................... 164 7.2 Glucose Repression ........................................................................... 164 7.2.1 Introduction ............................................................................ 164 7.2.2 MIGI Protein is a DNA-Binding Transcriptional Repressor ................................................................................ 165 Contents xiii 7.2.3 Combined Role of GAL80 and MIGI Proteins in Glucose Repression ............................................................ 165 7.2.4 Binary and Graded Response ................................................. 166 7.2.5 GAIA Expression is Repressed by Glucose ........................... 169 References ................................................................................................... 170 7.3 Fine Regulation of GAL Genetic Switch ........................................... 170 7.3.1 Introduction ............................................................................ 170 7.3.2 Basal and Induced Expression ................................................ 171 7.3.3 Post-Translational Modification of GAL4 Protein ................. 173 References ................................................................................................... 174 8 Paradigmatic Role of Galactose Switch ................................................... 175 8.1 GAL Regulon and Genomics ............................................................. 175 8.1.1 Introduction ............................................................................ 175 8.1.2 Functional Profiling of Fitness ............................................... 177 8.1.3 Analysis Genome-Wide DNA Binding .................................. 179 8.1.4 Genomic Approach for Network Analysis ............................. 180 References ................................................................................................... 183 8.2 GAL Regulon and Systems Biology .................................................. 183 8.2.1 Introduction ............................................................................ 183 8.2.2 Quantitative Basis of GAL Genetic Switch ............................ 184 8.2.3 Long-Term Adaptation Revisited ........................................... 188 8.2.4 Feedback Loops of GAL Regulon .......................................... 190 References ................................................................................................... 193 8.3 Galactose Metabolism and Evolution ................................................ 193 8.3.1 Introduction ............................................................................ 193 8.3.2 Evolution of Galactose Metabolism ....................................... 194 8.3.3 Evolution of Genomic Organization of Galactose Metabolic Enzymes ........................................... 196 8.3.4 Adaptive Evolution of Galactose Metabolism ....................... 197 8.3.5 Evolution of Regulatory Network of Galactose Metabolism ........................................................ 199 8.3.6 Genome Duplication in Saccharomyces ................................. 200 References ................................................................................................... 201 8.4 GAL Switch as a Tool ........................................................................ 202 8.4.1 Introduction ............................................................................ 202 8.4.2 High-level Protein Expression ................................................ 202 8.4.3 Dihybrid Analysis ................................................................... 203 8.4.4 Dihybrid Approach for Genetic Analysis .............................. 204 8.4.5 Genome-Wide Protein-Protein Interaction ............................ 206 8.4.6 GAL Switch as a Tool in Higher Organisms ......................... 207 References ................................................................................................... 208 xiv Contents 8.5 Lessons Learned ................................................................................ 208 8.5.1 Introduction ............................................................................ 208 8.5.2 Robustness and Fragility ........................................................ 210 8.5.3 Stochasticity and Phenotypic Variation .................................. 211 References ................................................................................................... 214 Index .................................................................................................................. 215
adam_txt	Contents 1 Introduction. 1.1 An Overview . 1 1.1.1 A General Perspective . 1 1.1.2 An Aside on Analogy . 2 References . 3 1.2 Yeast is a Eukaryotic Model Organism . 4 1.2.1 Introduction . 4 1.2.2 Model Organisms . 4 1.2.3 Yeast . 5 1.2.4 Life Cycle of Haploid Yeast . 7 1.2.5 Life Cycle of Diploid Yeast . 9 1.2.6 Information Transfer from Parents to Descendents . 9 1.2.7 Human Life Cycle . 13 References . 14 1.3 A Cell as a Biochemical Entity . 15 1.3.1 Introduction . 15 1.3.2 Chemical Constituents . 15 1.3.3 Macroscopic and Microscopic Aspects of Metabolism . 16 1.3.4 Biochemical Transactions . 17 1.3.5 Energy Transactions . 19 References . 23 2 Adaptation to Environment . 25 2.1 Growth and Multiplication . 25 2.1.1 Introduction . 25 2.1.2 Growth Kinetics . 25 2.1.3 Effect of Nutrients on Growth . 28 2.1.4 Metabolic Strategy . 29 References . 33 x Contents 2.2 Enzyme Adaptation. 33 2.2.1 Introduction. 33 2.2.2 Adaptation to Nutrients . 33 2.2.3 Long-Term Adaptation . 35 2.2.4 Single-Cell Analysis of Long-Term Adaptation . 36 2.2.5 Galactose Metabolism . 38 References . 41 2.3 Induction of Leloir Enzymes . 42 2.3.1 Introduction . 42 2.3.2 Galactose Induces the Synthesis of Leloir Enzymes . 43 2.3.3 Galactose Activates the Transcription of GAL Genes . 43 2.3.4 Galactose Activates a Genetic Program . 46 References . 47 3 Genetic Dissection of Galactose Metabolism . 49 3.1 Genetic Analysis of GAL Regulon . 49 3.1.1 Introduction . 49 3.1.2 Mutant Hunt . 49 3.1.3 Segregation Analysis . 50 3.1.4 Complementation Analysis . 50 3.1.5 Concept of an Alíele . 54 3.1.6 Special Cases of Complementation . 56 3.1.7 Aberrant Segregation and Recombination Model . 58 References . 61 3.2 Genetic Mapping of GAL Genes . 62 3.2.1 Introduction . 62 3.2.2 Tetrad Analysis . 62 3.2.3 Mapping of GAL Genes by Tetrad Analysis . 64 3.2.4 Map Distance and Recombination Frequency . 67 3.2.5 An Aside on Mapping of Human Genes by Linkage Analysis . 69 References . 76 4 Genetic Analysis GAL Genetic Switch . 79 4.1 Negative Control by the Repressor . 79 4.1.1 Introduction . 79 4.1.2 Discovery of a Repressor of GAL Regulon . 80 Reference . 82 4.2 Operator Repressor Model of GAL Regulon . 82 4.2.1 Introduction . 82 4.2.2 Testing the Predictions of the Model . 82 References . 84 Contents xi 4.3 Genetic Interactions . 85 4.3.1 Introduction . 85 4.3.2 Recessivity and Dominance . 85 4.3.3 Negative Dominance . 87 4.3.4 Epistasis . 87 4.3.5 Allele-Specific Interactions . 89 References . 90 4.4 Conditional Lethal Mutations . 90 4.4.1 Introduction . 90 4.4.2 Temperature-Sensitive Alíele of GAL3 . 91 4.4.3 Temperature-Sensitive Alíele of GAL4 . 92 References . 93 4.5 Revised Model of GAL Genetic Switch . 94 4.5.1 Introduction . 94 4.5.2 Protein-Protein Interaction Model . 94 4.5.3 Interaction Between GAL4 and GAL80 Proteins . 95 References . 97 4.6 Signal Transduction in GAL Regulon . 97 4.6.1 Introduction . 97 4.6.2 Catalytic Model . 98 References . 99 5 Molecular Genetics of GAL Regulon . 101 5.1 Cloning: A Perspective . 101 5.1.1 Introduction . 101 5.1.2 Vectors, Genetic Transformation, and Recombinant DNA Technology . 102 5.1.3 DNA Cloning . 104 5.1.4 Genomic DNA Library . 105 5.1.5 cDNA Library . 105 5.1.6 Isolation of Recombinant Clones . 106 5.1.7 Development of Yeast Shuttle Vectors . 107 References . 110 5.2 Genomic Organization of GAL Cluster . 110 5.2.1 Introduction . 110 5.2.2 Cloning of the GAL Cluster . 111 5.2.3 Analysis of GAL1-I0 Intergenic Region . 113 References . 118 5.3 Isolation of GALĄ: The Transcriptional Activator . 118 5.3.1 Introduction . 118 5.3.2 Cloning of GAL4 by Functional Complementation . 120 5.3.3 GAL4 Protein Binds Upstream Activating Sequences . 120 5.3.4 GAL4 Protein Binds GAL80 Protein . 123 xii Contents 5.3.5 GAL4 Protein is Modular . 124 References . 129 5.4 Isolation of GAL80: The Repressor . 131 5.4.1 Introduction . 131 5.4.2 Cloning of GAL80 by Genetic Suppression . 131 5.4.3 Autogenous Regulation of GAL80 Expression . 132 5.4.4 Mutational Analysis of GAL80 . 133 References . 134 5.5 Isolation of GAL3: The Signal Transducer . 135 5.5.1 Introduction . 135 5.5.2 Cloning of GAU. 135 5.5.3 GALI and GAL3 are Paralogues . 137 5.5.4 GALI is a Degenerate Signal Transducer . 137 5.5.5 Autogenous Regulation of GAL3 Expression . 138 5.5.6 An aside on Positional Cloning . 138 5.5.7 Restriction Fragment Length Polymorphism . 141 References . 141 6 Signal Transduction Revisited . 143 6.1 Revised Model of Signal Transduction . 143 6.1.1 Introduction . 143 6.1.2 Protein-Protein Interaction Model . 143 6.1.3 Testing the Predictions of the Protein-Protein Interaction Model . 144 6.1.4 Recent Analysis of Signal Transduction . 145 References . 150 6.2 Genetic Dissection of Signal Transduction . 150 6.2.1 Introduction . 150 6.2.2 Mutational Analysis of GAL3 . 151 6.2.3 Mutational Analysis of GAL80 . 154 References . 155 7 Versatile Galactose Genetic Switch . 157 7.1 Transcription Activation . 157 7.1.1 Introduction . 157 7.1.2 RNA Polymerase II . 158 7.1.3 Transcriptional Activation by Recruitment . 159 References . 164 7.2 Glucose Repression . 164 7.2.1 Introduction . 164 7.2.2 MIGI Protein is a DNA-Binding Transcriptional Repressor . 165 Contents xiii 7.2.3 Combined Role of GAL80 and MIGI Proteins in Glucose Repression . 165 7.2.4 Binary and Graded Response . 166 7.2.5 GAIA Expression is Repressed by Glucose . 169 References . 170 7.3 Fine Regulation of GAL Genetic Switch . 170 7.3.1 Introduction . 170 7.3.2 Basal and Induced Expression . 171 7.3.3 Post-Translational Modification of GAL4 Protein . 173 References . 174 8 Paradigmatic Role of Galactose Switch . 175 8.1 GAL Regulon and Genomics . 175 8.1.1 Introduction . 175 8.1.2 Functional Profiling of Fitness . 177 8.1.3 Analysis Genome-Wide DNA Binding . 179 8.1.4 Genomic Approach for Network Analysis . 180 References . 183 8.2 GAL Regulon and Systems Biology . 183 8.2.1 Introduction . 183 8.2.2 Quantitative Basis of GAL Genetic Switch . 184 8.2.3 Long-Term Adaptation Revisited . 188 8.2.4 Feedback Loops of GAL Regulon . 190 References . 193 8.3 Galactose Metabolism and Evolution . 193 8.3.1 Introduction . 193 8.3.2 Evolution of Galactose Metabolism . 194 8.3.3 Evolution of Genomic Organization of Galactose Metabolic Enzymes . 196 8.3.4 Adaptive Evolution of Galactose Metabolism . 197 8.3.5 Evolution of Regulatory Network of Galactose Metabolism . 199 8.3.6 Genome Duplication in Saccharomyces . 200 References . 201 8.4 GAL Switch as a Tool . 202 8.4.1 Introduction . 202 8.4.2 High-level Protein Expression . 202 8.4.3 Dihybrid Analysis . 203 8.4.4 Dihybrid Approach for Genetic Analysis . 204 8.4.5 Genome-Wide Protein-Protein Interaction . 206 8.4.6 GAL Switch as a Tool in Higher Organisms . 207 References . 208 xiv Contents 8.5 Lessons Learned . 208 8.5.1 Introduction . 208 8.5.2 Robustness and Fragility . 210 8.5.3 Stochasticity and Phenotypic Variation . 211 References . 214 Index . 215
any_adam_object	1
any_adam_object_boolean	1
author	Bhat, Paike Jayadeva
author_facet	Bhat, Paike Jayadeva
author_role	aut
author_sort	Bhat, Paike Jayadeva
author_variant	p j b pj pjb
building	Verbundindex
bvnumber	BV023110336
classification_rvk	WG 1940
ctrlnum	(OCoLC)229442649 (DE-599)DNB986339210
dewey-full	572.86529562
dewey-hundreds	500 - Natural sciences and mathematics
dewey-ones	572 - Biochemistry
dewey-raw	572.86529562
dewey-search	572.86529562
dewey-sort	3572.86529562
dewey-tens	570 - Biology
discipline	Biologie
discipline_str_mv	Biologie
format	Book
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02301nam a2200577 c 4500</leader><controlfield tag="001">BV023110336</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20080314 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">080201s2008 gw ad\|\| \|\|\|\| 00\|\|\| eng d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">986339210</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783540740148</subfield><subfield code="c">Gb. : EUR 128.35 (freier Pr.), sfr 209.00 (freier Pr.)</subfield><subfield code="9">978-3-540-74014-8</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540740147</subfield><subfield code="c">Gb. : EUR 128.35 (freier Pr.), sfr 209.00 (freier Pr.)</subfield><subfield code="9">3-540-74014-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)229442649</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB986339210</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.86529562</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WG 1940</subfield><subfield code="0">(DE-625)148511:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">570</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bhat, Paike Jayadeva</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Galactose regulon of yeast</subfield><subfield code="b">from genetics to systems biology</subfield><subfield code="c">Paike Jayadeva Bhat</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2008</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIV, 219 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Galactose</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Galactose</subfield><subfield code="x">genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Regulon</subfield><subfield code="x">genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Systems biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Yeast fungi</subfield><subfield code="x">Molecular genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Yeasts</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Galactose-Operon</subfield><subfield code="0">(DE-588)4325829-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Hefeartige Pilze</subfield><subfield code="0">(DE-588)4230509-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Genregulation</subfield><subfield code="0">(DE-588)4122166-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Regulon</subfield><subfield code="0">(DE-588)4353205-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Saccharomyces cerevisiae</subfield><subfield code="0">(DE-588)4178812-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Galactose</subfield><subfield code="0">(DE-588)4155818-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Hefeartige Pilze</subfield><subfield code="0">(DE-588)4230509-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Galactose</subfield><subfield code="0">(DE-588)4155818-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Regulon</subfield><subfield code="0">(DE-588)4353205-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Saccharomyces cerevisiae</subfield><subfield code="0">(DE-588)4178812-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Galactose-Operon</subfield><subfield code="0">(DE-588)4325829-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="2"><subfield code="a">Genregulation</subfield><subfield code="0">(DE-588)4122166-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="C">b</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016312944&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016312944</subfield></datafield></record></collection>
id	DE-604.BV023110336
illustrated	Illustrated
index_date	2024-07-02T19:48:05Z
indexdate	2024-07-09T21:11:15Z
institution	BVB
isbn	9783540740148 3540740147
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-016312944
oclc_num	229442649
open_access_boolean
owner	DE-355 DE-BY-UBR DE-188
owner_facet	DE-355 DE-BY-UBR DE-188
physical	XIV, 219 S. Ill., graph. Darst.
publishDate	2008
publishDateSearch	2008
publishDateSort	2008
publisher	Springer
record_format	marc
spelling	Bhat, Paike Jayadeva Verfasser aut Galactose regulon of yeast from genetics to systems biology Paike Jayadeva Bhat Berlin [u.a.] Springer 2008 XIV, 219 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Galactose Galactose genetics Regulon genetics Systems biology Yeast fungi Molecular genetics Yeasts Galactose-Operon (DE-588)4325829-3 gnd rswk-swf Hefeartige Pilze (DE-588)4230509-3 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Regulon (DE-588)4353205-6 gnd rswk-swf Saccharomyces cerevisiae (DE-588)4178812-6 gnd rswk-swf Galactose (DE-588)4155818-2 gnd rswk-swf Hefeartige Pilze (DE-588)4230509-3 s Galactose (DE-588)4155818-2 s Regulon (DE-588)4353205-6 s DE-604 Saccharomyces cerevisiae (DE-588)4178812-6 s Galactose-Operon (DE-588)4325829-3 s Genregulation (DE-588)4122166-7 s b DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016312944&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Bhat, Paike Jayadeva Galactose regulon of yeast from genetics to systems biology Galactose Galactose genetics Regulon genetics Systems biology Yeast fungi Molecular genetics Yeasts Galactose-Operon (DE-588)4325829-3 gnd Hefeartige Pilze (DE-588)4230509-3 gnd Genregulation (DE-588)4122166-7 gnd Regulon (DE-588)4353205-6 gnd Saccharomyces cerevisiae (DE-588)4178812-6 gnd Galactose (DE-588)4155818-2 gnd
subject_GND	(DE-588)4325829-3 (DE-588)4230509-3 (DE-588)4122166-7 (DE-588)4353205-6 (DE-588)4178812-6 (DE-588)4155818-2
title	Galactose regulon of yeast from genetics to systems biology
title_auth	Galactose regulon of yeast from genetics to systems biology
title_exact_search	Galactose regulon of yeast from genetics to systems biology
title_exact_search_txtP	Galactose regulon of yeast from genetics to systems biology
title_full	Galactose regulon of yeast from genetics to systems biology Paike Jayadeva Bhat
title_fullStr	Galactose regulon of yeast from genetics to systems biology Paike Jayadeva Bhat
title_full_unstemmed	Galactose regulon of yeast from genetics to systems biology Paike Jayadeva Bhat
title_short	Galactose regulon of yeast
title_sort	galactose regulon of yeast from genetics to systems biology
title_sub	from genetics to systems biology
topic	Galactose Galactose genetics Regulon genetics Systems biology Yeast fungi Molecular genetics Yeasts Galactose-Operon (DE-588)4325829-3 gnd Hefeartige Pilze (DE-588)4230509-3 gnd Genregulation (DE-588)4122166-7 gnd Regulon (DE-588)4353205-6 gnd Saccharomyces cerevisiae (DE-588)4178812-6 gnd Galactose (DE-588)4155818-2 gnd
topic_facet	Galactose Galactose genetics Regulon genetics Systems biology Yeast fungi Molecular genetics Yeasts Galactose-Operon Hefeartige Pilze Genregulation Regulon Saccharomyces cerevisiae
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016312944&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT bhatpaikejayadeva galactoseregulonofyeastfromgeneticstosystemsbiology

Verfügbarkeit

Es ist kein Print-Exemplar vorhanden.

Fernleihe Bestellen Achtung: Nicht im THWS-Bestand! Inhaltsverzeichnis

MARC

Datensatz im Suchindex

Es ist kein Print-Exemplar vorhanden.

Ähnliche Einträge