Protein Kinase CK2 — From Structure to Regulation:
CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putativ...
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
2001
|
| Schriftenreihe: | Developments in Molecular and Cellular Biochemistry
35 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell |
| Beschreibung: | 1 Online-Ressource (V, 187 p) |
| ISBN: | 9781461517238 |
| DOI: | 10.1007/978-1-4615-1723-8 |
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| 520 | |a CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell | ||
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Datensatz im Suchindex
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| author2 | Ahmed, Khalil Issinger, Olaf-Georg Allende, Jorge E. |
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| author_facet | Ahmed, Khalil Issinger, Olaf-Georg Allende, Jorge E. |
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| dewey-full | 572 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
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| dewey-search | 572 |
| dewey-sort | 3572 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| doi_str_mv | 10.1007/978-1-4615-1723-8 |
| format | Electronic eBook |
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| spelling | Protein Kinase CK2 — From Structure to Regulation edited by Khalil Ahmed, Olaf-Georg Issinger, Jorge E Allende Boston, MA Springer US 2001 1 Online-Ressource (V, 187 p) txt rdacontent c rdamedia cr rdacarrier Developments in Molecular and Cellular Biochemistry 35 CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell Biochemistry, general Biochemistry Proteinkinase CK2 (DE-588)4551046-5 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Proteinkinase CK2 (DE-588)4551046-5 s 2\p DE-604 Ahmed, Khalil edt Issinger, Olaf-Georg edt Allende, Jorge E. edt Erscheint auch als Druck-Ausgabe 9781461356967 Erscheint auch als Druck-Ausgabe 9780792376668 Erscheint auch als Druck-Ausgabe 9781461517245 https://doi.org/10.1007/978-1-4615-1723-8 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Protein Kinase CK2 — From Structure to Regulation Biochemistry, general Biochemistry Proteinkinase CK2 (DE-588)4551046-5 gnd |
| subject_GND | (DE-588)4551046-5 (DE-588)4143413-4 |
| title | Protein Kinase CK2 — From Structure to Regulation |
| title_auth | Protein Kinase CK2 — From Structure to Regulation |
| title_exact_search | Protein Kinase CK2 — From Structure to Regulation |
| title_full | Protein Kinase CK2 — From Structure to Regulation edited by Khalil Ahmed, Olaf-Georg Issinger, Jorge E Allende |
| title_fullStr | Protein Kinase CK2 — From Structure to Regulation edited by Khalil Ahmed, Olaf-Georg Issinger, Jorge E Allende |
| title_full_unstemmed | Protein Kinase CK2 — From Structure to Regulation edited by Khalil Ahmed, Olaf-Georg Issinger, Jorge E Allende |
| title_short | Protein Kinase CK2 — From Structure to Regulation |
| title_sort | protein kinase ck2 from structure to regulation |
| topic | Biochemistry, general Biochemistry Proteinkinase CK2 (DE-588)4551046-5 gnd |
| topic_facet | Biochemistry, general Biochemistry Proteinkinase CK2 Aufsatzsammlung |
| url | https://doi.org/10.1007/978-1-4615-1723-8 |
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