System engineering approach to planning Anticancer therapies:
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Weitere Verfasser: | , , , , |
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Format: | Elektronisch E-Book |
Sprache: | English |
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[Cham]
Springer
[2016]
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Schlagworte: | |
Online-Zugang: | BTU01 FHR01 FRO01 TUM01 UBM01 UBT01 UBW01 UEI01 UPA01 Volltext Inhaltsverzeichnis Abstract |
Beschreibung: | 1 Online-Ressource (IX, 235 Seiten, 55 illus., 17 illus. in color) |
ISBN: | 9783319280950 |
DOI: | 10.1007/978-3-319-28095-0 |
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Datensatz im Suchindex
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adam_text | SYSTEM ENGINEERING APPROACH TO PLANNING ANTICANCER THERAPIES
/ SWIERNIAK, ANDRZEJ
: 2016
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
CELL CYCLE AS AN OBJECT OF CONTROL
THERAPY OPTIMIZATION IN POPULATION DYNAMICS MODELS
STRUCTURED MODELS AND THEIR USE IN MODELING ANTICANCER THERAPIES
SIGNALING PATHWAYS DYNAMICS AND CANCER TREATMENT
MODEL IDENTIFICATION AND PARAMETER ESTIMATION
APPENDIXES: STABILITY AND CONTROLLABILITY OF DYNAMICAL SYSTEMS
PONTRYAGIN MAXIMUM PRINCIPLE AND OPTIMAL CONTROL
BIFURCATION ANALYSIS
NUMERICAL IMPLEMENTATION OF THE RUNGE KUTTA AND GILLESPIE METHODS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
SYSTEM ENGINEERING APPROACH TO PLANNING ANTICANCER THERAPIES
/ SWIERNIAK, ANDRZEJ
: 2016
ABSTRACT / INHALTSTEXT
THIS BOOK FOCUSES ON THE ANALYSIS OF CANCER DYNAMICS AND THE
MATHEMATICALLY BASED SYNTHESIS OF ANTICANCER THERAPY. IT SUMMARIZES THE
CURRENT STATE-OF-THE-ART IN THIS FIELD AND CLARIFIES COMMON
MISCONCEPTIONS ABOUT MATHEMATICAL MODELING IN CANCER. ADDITIONALLY, IT
ENCOURAGES CLOSER COOPERATION BETWEEN ENGINEERS, PHYSICIANS AND
MATHEMATICIANS BY SHOWING THE CLEAR BENEFITS OF THIS WITHOUT STATING
UNREALISTIC GOALS. DEVELOPMENT OF THERAPY PROTOCOLS IS REALIZED FROM AN
ENGINEERING POINT OF VIEW, SUCH AS THE SEARCH FOR A SOLUTION TO A
SPECIFIC CONTROL-OPTIMIZATION PROBLEM. SINCE IN THE CASE OF CANCER
PATIENTS, CONSECUTIVE MEASUREMENTS PROVIDING INFORMATION ABOUT THE
CURRENT STATE OF THE DISEASE ARE NOT AVAILABLE, THE CONTROL LAWS ARE
DERIVED FOR AN OPEN LOOP STRUCTURE.DIFFERENT FORMS OF THERAPY ARE
INCORPORATED INTO THE MODELS, FROM CHEMOTHERAPY AND ANTIANGIOGENIC
THERAPY TO IMMUNOTHERAPY AND GENE THERAPY, BUT THE CLASS OF MODELS
INTRODUCED IS BROAD ENOUGH TO INCORPORATE OTHER FORMS OF THERAPY AS
WELL. THE BOOK BEGINS WITH AN ANALYSIS OF CELL CYCLE CONTROL, MOVING ON
TO CONTROL EFFECTS ON CELL POPULATION AND STRUCTURED MODELS AND FINALLY
THE SIGNALING PATHWAYS INVOLVED IN CARCINOGENESIS AND THEIR INFLUENCE ON
THERAPY OUTCOME. IT ALSO DISCUSSES THE INCORPORATION OF INTRACELLULAR
PROCESSES USING SIGNALING PATHWAY MODELS, SINCE THE SUCCESSFUL TREATMENT
OF CANCER BASED ON ANALYSIS OF INTRACELLULAR PROCESSES, MIGHT SOON BE A
REALITY. IT BRINGS TOGETHER VARIOUS ASPECTS OF MODELING ANTICANCER
THERAPIES, WHICH UNTIL NOW HAVE BEEN DISTRIBUTED OVER A WIDE RANGE OF
LITERATURE.WRITTEN FOR RESEARCHERS AND GRADUATE STUDENTS INTERESTED IN
THE USE OF MATHEMATICAL AND ENGINEERING TOOLS IN BIOMEDICINE WITH
SPECIAL EMPHASIS ON APPLICATIONS IN CANCER DIAGNOSIS AND TREATMENT, THIS
SELF-CONTAINED BOOK CAN BE EASILY UNDERSTOOD WITH ONLY A MINIMAL BASIC
KNOWLEDGE OF CONTROL AND SYSTEM ENGINEERING METHODS AS WELL AS THE
BIOLOGY OF CANCER. ITS INTERDISCIPLINARY CHARACTER AND THE AUTHORS’
EXTENSIVE EXPERIENCE IN COOPERATING WITH CLINICIANS AND BIOLOGISTS MAKE
IT INTERESTING READING FOR RESEARCHERS FROM CONTROL AND SYSTEM
ENGINEERING LOOKING FOR APPLICATIONS OF THEIR KNOWLEDGE. SYSTEMS AND
MOLECULAR BIOLOGISTS AS WELL AS CLINICIANS WILL ALSO FIND NEW
INSPIRATION FOR THEIR RESEARCH
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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author2 | Świerniak, Andrzej Kimmel, Marek 1953- Smieja, Jaroslaw Puszynski, Krzysztof Psiuk-Maksymowicz, Krzysztof |
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author_GND | (DE-588)1146381581 |
author_facet | Świerniak, Andrzej Kimmel, Marek 1953- Smieja, Jaroslaw Puszynski, Krzysztof Psiuk-Maksymowicz, Krzysztof |
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discipline | Biologie Mathematik |
doi_str_mv | 10.1007/978-3-319-28095-0 |
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spelling | Świerniak, Andrzej edt System engineering approach to planning Anticancer therapies Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz [Cham] Springer [2016] © 2016 1 Online-Ressource (IX, 235 Seiten, 55 illus., 17 illus. in color) txt rdacontent c rdamedia cr rdacarrier Mathematics Cancer research Drug resistance Cell cycle System theory Biomathematics Mathematical and Computational Biology Systems Theory, Control Cancer Research Cell Cycle Analysis Drug Resistance Mathematik Kimmel, Marek 1953- (DE-588)1146381581 edt Smieja, Jaroslaw edt Puszynski, Krzysztof edt Psiuk-Maksymowicz, Krzysztof edt Erscheint auch als Druckausgabe 978-3-319-28093-6 https://doi.org/10.1007/978-3-319-28095-0 Verlag URL des Erstveröffentlichers Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028994351&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028994351&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
spellingShingle | System engineering approach to planning Anticancer therapies Mathematics Cancer research Drug resistance Cell cycle System theory Biomathematics Mathematical and Computational Biology Systems Theory, Control Cancer Research Cell Cycle Analysis Drug Resistance Mathematik |
title | System engineering approach to planning Anticancer therapies |
title_auth | System engineering approach to planning Anticancer therapies |
title_exact_search | System engineering approach to planning Anticancer therapies |
title_full | System engineering approach to planning Anticancer therapies Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz |
title_fullStr | System engineering approach to planning Anticancer therapies Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz |
title_full_unstemmed | System engineering approach to planning Anticancer therapies Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz |
title_short | System engineering approach to planning Anticancer therapies |
title_sort | system engineering approach to planning anticancer therapies |
topic | Mathematics Cancer research Drug resistance Cell cycle System theory Biomathematics Mathematical and Computational Biology Systems Theory, Control Cancer Research Cell Cycle Analysis Drug Resistance Mathematik |
topic_facet | Mathematics Cancer research Drug resistance Cell cycle System theory Biomathematics Mathematical and Computational Biology Systems Theory, Control Cancer Research Cell Cycle Analysis Drug Resistance Mathematik |
url | https://doi.org/10.1007/978-3-319-28095-0 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028994351&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028994351&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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